Automated Capillary Electrophoresis System Compatible with Multiple Detectors for Potential In Situ Spaceflight Missions

Zamuruyev, Konstantin; Santos, Mauro Sérgio Ferreira; Mora, María F.; Kurfman, Emily; Noell, Aaron C.; Willis, Peter

doi:10.1021/acs.analchem.1c02119

Cited by 28 publications

(46 citation statements)

References 30 publications

(62 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(A) (B) A fully automated, portable capillary electrophoresis analyzer can be also compatible with different detectors-ESI-MS, C 4 D and LIF-for potential in-situ deployment in spaceflight missions and exploration [108]. The implementation of these detectors can enable the analysis of a wide range of organic compounds potentially indicative of life, as well as inorganic compounds that can serve as indicators of habitability.…”

Section: Discussionmentioning

confidence: 99%

Application of Capillary Electrophoresis for Determination of Inorganic Analytes in Waters

Poboży

Trojanowicz

2021

Molecules

View full text Add to dashboard Cite

Aside from HPLC and GC, capillary electrophoresis (CE) is one of the most important techniques for high-performance separations in modern analytical chemistry. Its main advantages are the possibility of using different detection techniques, the possibility of in-capillary sample processing for preconcentration or derivatization, and ease of instrumental miniaturization down to the microfluidic scale. Those features are utilized in the separation of macromolecules in biochemistry and in genetic investigations, but they can be also used in determinations of inorganic ions in water analysis. This review, based on about 100 original research works, presents applications of CE methods in water analysis reported in recent decade, mostly regarding conductivity detection or indirect UV detection. The developed applications include analysis of high salinity sea waters, as well as analysis of other surface waters and drinking waters.

show abstract

Section: Discussionmentioning

confidence: 99%

Application of Capillary Electrophoresis for Determination of Inorganic Analytes in Waters

Poboży

Trojanowicz

2021

Molecules

View full text Add to dashboard Cite

show abstract

“…The core of the OCEANS hardware is a capillary-based CE system compatible with all three detection modes, described in detail previously (Zamuruyev et al, 2021). Briefly, the system is based on rotor-stator style valves to allow robust sample injection with mechanical decoupling of the high voltage (HV) electrode reservoir from the rest of the fluidic system.…”

Section: Oceans Hardwarementioning

confidence: 99%

Europan Molecular Indicators of Life Investigation (EMILI) for a Future Europa Lander Mission

Brinckerhoff¹,

Willis²,

Ricco³

et al. 2022

Front. Space Technol.

Self Cite

View full text Add to dashboard Cite

The Europan Molecular Indicators of Life Investigation (EMILI) is an instrument concept being developed for the Europa Lander mission currently under study. EMILI will meet and exceed the scientific and technical/resource requirements of the organic composition analyzer identified as a core instrument on the Lander. EMILI tightly couples two complementary analytical techniques, based on 1) liquid extraction and processing with capillary electrophoresis and 2) thermal and chemical extraction with gas chromatography, to robustly detect, structurally characterize, and quantify the broadest range of organics and other Europan chemicals over widely-varying concentrations. Dual processing and analysis paths enable EMILI to perform a thorough characterization of potential molecular biosignatures and contextual compounds in collected surface samples. Here we present a summary of the requirements, design, and development status of EMILI with projected scientific opportunities on the Europa Lander as well as on other potential life detection missions seeking potential molecular biosignatures in situ.

show abstract

“…Significant advances have been made in maturing CE techniques for space applications (Zamuruyev et al, 2021).…”

Section: Ionization Sources and Molecular Separation Techniquesmentioning

confidence: 99%

Planetary Mass Spectrometry for Agnostic Life Detection in the Solar System

Chou

Mahaffy

Trainer

et al. 2021

Front. Astron. Space Sci.

View full text Add to dashboard Cite

For the past fifty years of space exploration, mass spectrometry has provided unique chemical and physical insights on the characteristics of other planetary bodies in the Solar System. A variety of mass spectrometer types, including magnetic sector, quadrupole, time-of-flight, and ion trap, have and will continue to deepen our understanding of the formation and evolution of exploration targets like the surfaces and atmospheres of planets and their moons. An important impetus for the continuing exploration of Mars, Europa, Enceladus, Titan, and Venus involves assessing the habitability of solar system bodies and, ultimately, the search for life—a monumental effort that can be advanced by mass spectrometry. Modern flight-capable mass spectrometers, in combination with various sample processing, separation, and ionization techniques enable sensitive detection of chemical biosignatures. While our canonical knowledge of biosignatures is rooted in Terran-based examples, agnostic approaches in astrobiology can cast a wider net, to search for signs of life that may not be based on Terran-like biochemistry. Here, we delve into the search for extraterrestrial chemical and morphological biosignatures and examine several possible approaches to agnostic life detection using mass spectrometry. We discuss how future missions can help ensure that our search strategies are inclusive of unfamiliar life forms.

show abstract

Automated Capillary Electrophoresis System Compatible with Multiple Detectors for Potential In Situ Spaceflight Missions

Cited by 28 publications

References 30 publications

Application of Capillary Electrophoresis for Determination of Inorganic Analytes in Waters

Application of Capillary Electrophoresis for Determination of Inorganic Analytes in Waters

Europan Molecular Indicators of Life Investigation (EMILI) for a Future Europa Lander Mission

Planetary Mass Spectrometry for Agnostic Life Detection in the Solar System

Contact Info

Product

Resources

About