Automated Breath-Hold Perfusion SPECT/CT Fusion Images of the Lungs

Suga, Kazuyoshi; Kawakami, Yoshiyuki; Iwanaga, Hideyuki; Tokuda, Osamu; Matsunaga, Naofumi

doi:10.2214/ajr.06.1290

Cited by 28 publications

(25 citation statements)

References 21 publications

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“…Conversely, in 4 other patients who did not have PE in vessels in the lung territory, perfusion defects were observed in the territory despite the absence of PE from the branches (50). There was, therefore, an unexpected dissociation between the localized PE and lung perfusion defects in some patients (50), although correlation with fusion images previously appeared useful for clarifying the cause of perfusion defects (51).…”

Section: Technical Studiesmentioning

confidence: 89%

SPECT in Acute Pulmonary Embolism

Stein¹,

Freeman²,

Sostman³

et al. 2009

J Nucl Med

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The purpose of this review was to evaluate the accuracy of SPECT in acute pulmonary embolism. Sparse data are available on the accuracy of SPECT based on an objective reference test. Several investigations were reported in which the reference standard for the diagnosis of pulmonary embolism was based in part on the results of SPECT or planar ventilation-perfusion (V/Q) imaging. The sensitivity of SPECT in all but one investigation was at least 90%, and specificity also was generally at least 90%. The sensitivity of SPECT in 4 of 5 investigations was higher than that of planar V/Q imaging. The specificity of SPECT was generally higher, equal, or only somewhat lower than that of planar V/Q imaging. Most investigators reported nondiagnostic SPECT V/Q scans in no more than 3% of cases. Methods of obtaining SPECT images, methods of obtaining planar V/Q images, and the criteria for interpretation varied. The general impression is that SPECT is more advantageous than planar V/Q imaging.

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Section: Technical Studiesmentioning

confidence: 89%

SPECT in Acute Pulmonary Embolism

Stein¹,

Freeman²,

Sostman³

et al. 2009

J Nucl Med

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“…These characteristics are especially suitable for oncology [14,[104][105][106][107][108] where detailed anatomical localization is needed. Other investigators have reported using the higher-performance SPECT/CT systems for applications in orthopedics [129][130][131][132], infection and inflammation [133][134][135][136][137][138], pulmonary function [139,140], and endocrinology [141], where the improved anatomical localization helps identify areas of disease that can be difficult to discriminate with SPECT alone. As previously mentioned, high-resolution CT performance also can be used to define target anatomy to improve the quantitation of absolute radionuclide uptake in small lesions such as tumors or in the myocardium.…”

Section: Current Spect/ct Technologiesmentioning

confidence: 99%

“…Clinical Applications of SPECT/CT Cited Anatomical/Disease Site Radiopharmaceutical SPECT/CT Application Adrenal masses 123 I-metaiodobenzylguanidine, 75 Se-cholesterol Anatomical localization [161] Biliary leak 99m Tc-diisopropyl iminodiacetic acid Anatomical localization [141] Bone scintigraphy 99m Tc-methylene diphosphonate, 99m Tc-dicarboxypropane diphosphonate Anatomical localization, attenuation correction [162][163][164][165][166][167][168][169] Brain cancer 99m Tc-tetrofosmin Anatomical localization [170] Breast cancer 99m Tc-sestamibi Anatomical localization [171] Colorectal cancer 99m Tc-labelled macroaggregated albumin Hepatic artery infusion of chemotherapy [172] Coronary artery calcification 99m Tc-tetrofosmin Head/neck cancer L-3-123 I-iodine-alpha-methyl-tyrosine, 123 I-labeled L19(scFv)2 antibody Anatomical localization [175][176][177] Hepatic haemangioma 99m Tc-labelled red blood cells Anatomical localization [178,179] Hepatic carcinoma 99m Tc-macroaggregated albumin Anatomical localization [180] Human immunodeficiency virus (HIV) 99m Tc-sulfur colloid Anatomical localization of microbicide surrogate [138] Infection Gallium-67, 111 In-labeled leukocytes Anatomical localization [133][134][135][136] Left ventricular function 99m Tc-tetrofosmin Regional wall motion evaluation, myocardial muscle mass, ejection fraction, cardiac volumes [118] Lung (ventilation/perfusion) 99m Tc-Technegas, 99m Tc-macroaggregated albumin Anatomical localization and registration of ventilation-perfusion patterns [139,140] Lung cancer 99m Tc-sestamibi, 99m Tc-depreotide Anatomical localization [181][182]…”

mentioning

confidence: 99%

Technological Development and Advances in Single-Photon Emission Computed Tomography/Computed Tomography

Seo

Marì

Hasegawa

2008

Seminars in Nuclear Medicine

170

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SPECT/CT has emerged over the past decade as a means of correlating anatomical information from CT with functional information from SPECT. The integration of SPECT and CT in a single imaging device facilitates anatomical localization of the radiopharmaceutical to differentiate physiological uptake from that associated with disease and patient-specific attenuation correction to improve the visual quality and quantitative accuracy of the SPECT image. The first clinically available SPECT/CT systems performed emission-transmission imaging using a dual-headed SPECT camera and a low-power x-ray CT sub-system. Newer SPECT/CT systems are available with high-power CT sub-systems suitable for detailed anatomical diagnosis, including CT coronary angiography and coronary calcification that can be correlated with myocardial perfusion measurements. The high-performance CT capabilities also offer the potential to improve compensation of partial volume errors for more accurate quantitation of radionuclide measurement of myocardial blood flow and other physiological processes and for radiation dosimetry for radionuclide therapy. In addition, new SPECT technologies are being developed that significantly improve the detection efficiency and spatial resolution for radionuclide imaging of small organs including the heart, brain, and breast, and therefore may provide new capabilities for SPECT/CT imaging in these important clinical applications.

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“…It also degrades image sharpness and smears ill-defined perfusion defects [10][11][12][13]. The recently developed deep-inspiratory BrH (DIBrH) SPECT can improve these adverse lung motion effects and provides reliable SPECT-CT fusion images [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Findings of hepatopulmonary syndrome on breath-hold perfusion SPECT-CT fusion images

Suga¹,

Kawakami²,

Iwanaga

et al. 2009

Ann Nucl Med

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Pulmonary perfusion SPECT-CT fusion images were used to characterize CT manifestations of intrapulmonary arteriovenous communications (AVC) causing right-to-left shunt and hepatopulmonary syndrome (HPS). After scanning the whole body and obtaining multiple view images of the lung, deep-inspiratory breath-hold (DIBrH) SPECT was obtained in 2 patients with HPS, which was automatically and three-dimensionally co-registered with DIBrH CT. In both patients, the whole body scan depicted systemic organs and confirmed the existence of right-to-left shunt. DIBrH SPECT-CT fusion images showed that perfusion defects were predominantly located at subpleural reticulo-nodular opacities and/or dilated vessels in the lung base. Subpleural reticulo-nodular opacities and/or dilated vessels in the lung base appear to be characteristic CT manifestation of intrapulmonary AVC in HPS.

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Automated Breath-Hold Perfusion SPECT/CT Fusion Images of the Lungs

Cited by 28 publications

References 21 publications

SPECT in Acute Pulmonary Embolism

SPECT in Acute Pulmonary Embolism

Technological Development and Advances in Single-Photon Emission Computed Tomography/Computed Tomography

Findings of hepatopulmonary syndrome on breath-hold perfusion SPECT-CT fusion images

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