Automated behavioural analysis in animal pain studies

Jourdan, Didier; Ardid, Denis; Eschalier, Alain

doi:10.1006/phrs.2000.0760

Cited by 22 publications

(21 citation statements)

References 26 publications

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“…It is reported that the frequency of spontaneous movement is reduced in animal models of pain, (28)(29)(30)(31) motor disability, (37) and several neurogenic and mental disorders. (38,39) This study did not directly address the underlying mechanism by which FGF-23Ab ameliorated muscle weakness and decreased spontaneous activity in Hyp mice.…”

Section: Discussionmentioning

confidence: 99%

“…From preclinical studies, pain is known to depress spontaneous behaviors such as locomotion, exploration, and rearing and enhance noxious stimulus-related withdrawal responses such as writhing and flinching. (28)(29)(30)(31)(32) Moreover, many analgesic treatments restore suppressed spontaneous behaviors along with providing pain relief. (29)(30)(31) Therefore, we recorded spontaneous movement in Hyp and wild-type mice during the nighttime.…”

Section: Effects Of Fgf-23ab On Spontaneous Movementmentioning

confidence: 99%

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Anti-FGF-23 neutralizing antibodies ameliorate muscle weakness and decreased spontaneous movement of Hyp mice

Aono

Higuchi

Yamazaki

et al. 2010

Journal of Bone and Mineral Research

101

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Fibroblast growth factor 23 (FGF-23) plays causative roles in the development of several hypophosphatemic rickets/osteomalacia such as X-linked hypophosphatemic rickets/osteomalacia (XLH) and tumor-induced rickets/osteomalacia. Patients with hypophosphatemic rickets/osteomalacia often complain of muscle weakness and bone pain that severely affect daily activities of these patients. The purpose of this study was to examine whether anti-FGF-23 antibodies, which have been shown to improve hypophosphatemia and rachitic changes of juvenile Hyp mice in a murine model of XLH, also ameliorate hypophosphatemic osteomalacia and affect muscle force and spontaneous motor activity in adult Hyp mice. Repeated injections of anti-FGF-23 antibodies increased serum phosphate and 1,25-dihydroxyvitmain D levels and enhanced mineralization of osteoid in adult Hyp mice, whereas bone length did not change. We found that grip strength was weaker and that spontaneous movement was less in adult Hyp mice than in wild-type mice. In addition, FGF-23 antibodies increased grip strength and spontaneous movement. These results suggest that the inhibition of excess FGF-23 action not only ameliorates hypophosphatemia and impaired mineralization of bone but also improves muscle weakness and daily activities of patients with FGF-23-related hypophosphatemic rickets/osteomalacia. ß

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Section: Discussionmentioning

confidence: 99%

Section: Effects Of Fgf-23ab On Spontaneous Movementmentioning

confidence: 99%

Anti-FGF-23 neutralizing antibodies ameliorate muscle weakness and decreased spontaneous movement of Hyp mice

Aono

Higuchi

Yamazaki

et al. 2010

Journal of Bone and Mineral Research

101

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“…The second approach involves a videotracking system employing a pattern recognition algorithm to discriminate between pain-related behaviors (grooming, licking and biting) and unspecific behaviors (Jourdan et al, 1997(Jourdan et al, , 1999. This method is limited in the capacity to distinguish between different pain-related behaviors, i.e., static pain behaviors such as paw lifting and twisting (Jourdan et al, 2001). The third approach is to count flinch activity by detecting electromagnetic field change produced by movement of a lightweight metal band placed on the paw (Mannino et al, 2006;Snijdelaar et al, 2005;Yaksh et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

A novel automated method for measuring the effect of analgesics on formalin-evoked licking behavior in rats

Sakiyama

Sujaku

Furuta

2008

Journal of Neuroscience Methods

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“…Paw withdrawal caused by the stimulation is registered as a response. Several other behavioral tests have been used to measure pain in animals, but because of lack of sufficient space to cover this topic adequately, we refer the reader to several papers and reviews 14,19,77,88,120,121 that address methods used to quantify pain in animals.…”

Section: Literature Identificationmentioning

confidence: 99%

Animal Models of Cancer Pain

Pacharinsak

Beitz²

2010

Animal Models of Pain

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220Pain is one of the most common and distressing symptoms experienced by both human and veterinary oncology patients with advanced cancer. In humans, unrelieved pain can disrupt and interfere with activities of daily living, quality of life, and mood, 26,173 and domestic animals typically are euthanized when pain is no longer adequately controlled. 138 New developments in cancer detection and therapy have occurred over the past decade. These developments are contributing to longer life expectancies and have raised important issues related to quality of life, as attention has focused increasingly on how to manage cancer pain effectively. 91,115,134 This increased attention is true in the fields of both human and veterinary medicine. Human cancer patients who are in advanced stages of the disease, particularly those with bone metastasis, report that they experience significant pain, and pain intensity appears to be related to the degree of bone destruction. Similarly, pain secondary to cancer in domestic animals is a key concern in veterinary practice and should be addressed promptly to alleviate suffering, stress, and anxiety and to improve quality of life. Not only do cancer patients have to deal with persistent pain, they also often experience 'breakthrough pain.' Breakthrough pain-intermittent episodes of extreme pain-occurs spontaneously or after movement or weight-bearing of the affected leg. 114,133 Canine osteosarcoma has many clinical and biological similarities to human osteosarcoma, and affected dogs show signs of both ongoing and breakthrough pain. 37 In addition to cancer-induced pain, human patients also experience pain caused by the very therapies used to treat the cancer. Almost 30% of adult cancer patients and 60% of pediatric cancer patients who have undergone treatments that include radiation, chemotherapy, or surgery also have experienced pain resulting from these therapeutic procedures. 49,174 Whether radiation treatment and chemotherapy also induce pain in domestic animals is virtually impossible to address, because carefully controlled studies have not examined this issue.Pain intensity varies among cancer patients and is dependent on a patient's pain sensitivity, the type of cancer, and the tumor location. 48,49 Cancer treatment guidelines provided by the World Health Organization have been used in oncology and pain treatment clinics. 20,25,92,113,117,119,163 Treatment of human cancer patients include the use of opioids, nonsteroidal antiinflammatory drugs (NSAIDs), corticosteroids, local anesthetics, antidepressants, and anticonvulsants either alone or in combination. Similarly in veterinary medicine, the goal of palliative therapy in cancer patients is to control pain from an incurable tumor and to support overall quality of life. 165 Therefore, opioids, NSAIDs, and bisphosphonates are used in addition to surgery and radiation therapy and are the drugs of choice in treating domestic animals with cancer pain, particularly those suffering from osteosarcoma and other forms of bone cancer. 1...

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Automated behavioural analysis in animal pain studies

Cited by 22 publications

References 26 publications

Anti-FGF-23 neutralizing antibodies ameliorate muscle weakness and decreased spontaneous movement of Hyp mice

Anti-FGF-23 neutralizing antibodies ameliorate muscle weakness and decreased spontaneous movement of Hyp mice

A novel automated method for measuring the effect of analgesics on formalin-evoked licking behavior in rats

Animal Models of Cancer Pain

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