Automated assessment of intranasal trigeminal function

Hummel, Thomas; Kaehling, C; Grosse, F.

doi:10.4193/rhin15.002

Cited by 24 publications

(31 citation statements)

References 32 publications

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“…Participants’ trigeminal sensitivity was assessed using a CO 2 stimulator [31]. A series of CO 2 stimuli was presented to the participants through a standard bilateral nasal cannula.…”

Section: Methodsmentioning

confidence: 99%

“…Objective measurements included trigeminal sensitivity to CO 2 and lateralization abilities for eucalyptol. Participants’ trigeminal sensitivity was assessed using a CO 2 stimulator [ 31 ]. A series of CO 2 stimuli was presented to the participants through a standard bilateral nasal cannula.…”

Section: Methodsmentioning

confidence: 99%

“…Stimulus duration increased by 50 ms from one stimulus to the other, starting at 100 ms until the subject felt a burning or stinging sensation in the nose and pushed a button to indicate that. After that stimulus, duration was decreased until the subject did not indicate a painful sensation by pressing the button anymore; and then the duration was increased again [ 31 ]. Maximum stimulus duration was 2000 ms. To ensure maximal reliability, this measurement was taken three times within each session, proceeded by a trial measurement.…”

Section: Methodsmentioning

confidence: 99%

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Effects of “trigeminal training” on trigeminal sensitivity and self-rated nasal patency

Oleszkiewicz

Schultheiss

Schriever

et al. 2018

Eur Arch Otorhinolaryngol

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PurposePatients with the feeling of a congested nose not always suffer from an anatomical obstruction but might just have a low trigeminal sensibility, which prevents them from perceiving the nasal airstream. We examined whether intermittent trigeminal stimulation increases sensitivity of the nasal trigeminal nerve and whether this effect is accompanied by subjective improvement of nasal breathing.MethodThirty-five patients (Mage = 58.4 years; SD = 14.8; Minage = 21 years; Maxage = 79 years; 43% females) and 30 healthy controls (Mage = 36.7 years, SD = 14.5; Minage = 20 years; Maxage = 73 years; 60% females) participated in a study comprised of two sessions separated by “trigeminal training”. During each session, trigeminal sensitivity towards CO2, trigeminal lateralization abilities and ratings of nasal patency were assessed. Age and training compliance were controlled.Results“Trigeminal training” had a positive effect on trigeminal sensitivity in both groups, (p = .027) and this effect depended on the training compliance (p < .001). “Trigeminal training” had no effect on lateralization abilities of the subjects (p > .05). Ratings of nasal patency increased in patients (p = .03), but not in controls.Conclusions“Trigeminal training” consisting of intermittent presentation of diverse stimulants leads to an increase of trigeminal sensitivity, but this effect depended on the training compliance. Importantly, in patients, this training is also associated with an increase in self-rated nasal patency.

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“…Participants’ trigeminal sensitivity was assessed using a CO 2 stimulator [31]. A series of CO 2 stimuli was presented to the participants through a standard bilateral nasal cannula.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Effects of “trigeminal training” on trigeminal sensitivity and self-rated nasal patency

Oleszkiewicz

Schultheiss

Schriever

et al. 2018

Eur Arch Otorhinolaryngol

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show abstract

“…However, zero evaluations of intentionally supra‐threshold CO 2 stimuli are not specific to the present data set, but commonly recorded in similar studies. In extreme cases, when only the presence of a ceiling effect was investigated and CO 2 stimuli are administered in concentrations of up to 100%, about 5% of healthy subjects did not reliably perceive a stimulus of 2000 ms of pure CO 2 (Hummel, Kaehling, & Grosse, 2016). Nevertheless, the central tendency of the present ratings was unsuspicious up to almost ideally reflecting a linear concentration versus response relationship (Figure 2), and when used as an experimental human pain model, CO 2 stimuli figure among the best predictors of effects of analgesic drugs on clinical pain (Lötsch et al, 2014; Oertel & Lotsch, 2013).…”

Section: Discussionmentioning

confidence: 99%

Central encoding of the strength of intranasal chemosensory trigeminal stimuli in a human experimental pain setting

Lötsch

Oertel

Felden

et al. 2020

Human Brain Mapping

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An important measure in pain research is the intensity of nociceptive stimuli and their cortical representation. However, there is evidence of different cerebral representations of nociceptive stimuli, including the fact that cortical areas recruited during processing of intranasal nociceptive chemical stimuli included those outside the traditional trigeminal areas. Therefore, the aim of this study was to investigate the major cerebral representations of stimulus intensity associated with intranasal chemical trigeminal stimulation. Trigeminal stimulation was achieved with carbon dioxide presented to the nasal mucosa. Using a single-blinded, randomized crossover design, 24 subjects received nociceptive stimuli with two different stimulation paradigms, depending on the just noticeable differences in the stimulus strengths applied. Stimulus-related brain activations were recorded using functional magnetic resonance imaging with event-related design. Brain activations increased significantly with increasing stimulus intensity, with the largest cluster at the right Rolandic operculum and a global maximum in a smaller cluster at the left lower frontal orbital lobe. Region of interest analyses additionally supported an activation pattern correlated with the stimulus intensity at the piriform cortex as an area of special interest with the trigeminal input. The results support the piriform cortex, in addition to the secondary somatosensory cortex, as a major area of interest for stimulus strengthrelated brain activation in pain models using trigeminal stimuli. This makes both areas a primary objective to be observed in human experimental pain settings where trigeminal input is used to study effects of analgesics.

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“…This test takes advantage of the fact that the olfactory system is unable to locate the source of stimulation whereas the trigeminal system can (187) . The third, most recently developed device uses the summation properties of the trigeminal system and analyses the concentration a subject is able to bear over time when exposed to a trigeminal stimulus such as carbon dioxide (188,189) . There is a need for better intranasal trigeminal testing since none of these methods has yet found its way into routine rhinology workup.…”

Section: Trigeminal Testingmentioning

confidence: 99%

European position paper on diagnostic tools in rhinology

Rimmer

Hellings

Lund

et al. 2019

Rhin

114

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is the official Journal of the European and International Rhinologic Societies and appears quarterly in March, June, September and December. Cited in Pubmed, Current Contents, Index Medicus, Exerpta Medica and Embase Founded in 1963 by H.A.E. van Dishoeck, Rhinology is a worldwide non-profit making journal. The journal publishes original papers on basic research as well as clinical studies in the major field of rhinology, including physiology, diagnostics, pathology, immunology, medical therapy and surgery of both the nose and paranasal sinuses. Review articles and short communications are also pulished. All papers are peer-reviewed. Letters-to-the-editor provide a forum for comments on published papers, and are not subject to editorial revision except for correction of English language. In-depth studies that are too long to be included into a regular issue can be published as a supplement. Supple ments are not subject to peer-review.

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Automated assessment of intranasal trigeminal function

Abstract: We have demonstrated that the current approach is a reliable and valid measure of intranasal trigeminal function.

Cited by 24 publications

References 32 publications

Effects of “trigeminal training” on trigeminal sensitivity and self-rated nasal patency

Effects of “trigeminal training” on trigeminal sensitivity and self-rated nasal patency

Central encoding of the strength of intranasal chemosensory trigeminal stimuli in a human experimental pain setting

European position paper on diagnostic tools in rhinology

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