Automated Anatomical Labeling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject Brain

Tzourio‐Mazoyer, Nathalie; Landeau, Brigitte; Papathanassiou, Dimitri; Crivello, Fabrice; Etard, Olivier; Delcroix, Nicolas; Mazoyer, Bernard; Joliot, Marc

doi:10.1006/nimg.2001.0978

Cited by 14,549 publications

(10,857 citation statements)

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“…Rigid body affine coregistration of PET and MRI scans as well as MRI gray‐white matter segmentation, spatial normalization, and transformation of template ROIs to PET space were performed using the neuro tool. As a template, the Automatic Anatomic Labelling (AAL)13 template was used. Cortical ROIs were masked using a gray matter probability map with a threshold set at 0.75 and transformed to PET space using the affine transformation obtained from MR‐to‐PET coregistration.…”

Section: Methodsmentioning

confidence: 99%

Increased basal ganglia binding of ¹⁸F‐AV‐1451 in patients with progressive supranuclear palsy

et al. 2016

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BackgroundProgressive supranuclear palsy (PSP) is difficult to diagnose accurately. The recently developed tau PET tracers may improve the diagnostic work‐up of PSP.MethodsRegional tau accumulation was studied using 18F‐AV‐1451 PET in 11 patients with PSP and 11 age‐matched healthy controls in the Swedish BioFinder study.Results 18F‐AV‐1451 standard uptake volume ratios were significantly higher in the basal ganglia in PSP patients when compared with controls (globus pallidus 1.75 vs 1.50; putamen 1.51 vs 1.35). Retention in the basal ganglia was correlated with age in both groups (r = .43–.78, P < .05). In PSP, we observed a significant correlation between clinical deterioration measured with the PSP rating scale and standard uptake volume ratios in the globus pallidus (r = .74, P < .05). However, no 18F‐AV‐1451 retention was observed in the cerebral cortex or white matter of either PSP patients or controls, and autoradiography did not reveal any specific binding of AV‐1451 to PSP tau aggregates.ConclusionWe found higher 18F‐AV‐1451 retention in the basal ganglia of PSP patients when compared with healthy elderly controls, but also increases with age in both controls and patients. As a result of the overlap in retention between diagnostic groups and the age‐dependent increase present also in controls, 18F‐AV‐1451 PET might not reliably distinguish individual patients with PSP from controls. However, further studies are needed to evaluate whether 18F‐AV‐1451 PET might be useful as a progression marker in clinical PSP trials. © The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

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Section: Methodsmentioning

confidence: 99%

Increased basal ganglia binding of ¹⁸F‐AV‐1451 in patients with progressive supranuclear palsy

et al. 2016

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“…A frequency analysis was performed using the multitaper method based on Hanning tapers in order to identify the peak virtual channel in each of 84 Automated Anatomical Labeling (AAL; Tzourio‐Mazoyer et al, 2002) atlas‐based ROIs (excluding the cerebellum and some deep structures; see Figure 6a). The classifier input consisted of the raw time‐series for each of the 84 virtual sensors, baseline corrected and averaged in groups of 5 trials to improve SNR.…”

Section: Methodsmentioning

confidence: 99%

Spatiotemporal dynamics in human visual cortex rapidly encode the emotional content of faces

Dima

Perry

Messaritaki

et al. 2018

Human Brain Mapping

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Recognizing emotion in faces is important in human interaction and survival, yet existing studies do not paint a consistent picture of the neural representation supporting this task. To address this, we collected magnetoencephalography (MEG) data while participants passively viewed happy, angry and neutral faces. Using time‐resolved decoding of sensor‐level data, we show that responses to angry faces can be discriminated from happy and neutral faces as early as 90 ms after stimulus onset and only 10 ms later than faces can be discriminated from scrambled stimuli, even in the absence of differences in evoked responses. Time‐resolved relevance patterns in source space track expression‐related information from the visual cortex (100 ms) to higher‐level temporal and frontal areas (200–500 ms). Together, our results point to a system optimised for rapid processing of emotional faces and preferentially tuned to threat, consistent with the important evolutionary role that such a system must have played in the development of human social interactions.

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“…We extracted regional mean fMRI time series for 90 regions of interest (ROI) in the Anatomical Automatic Labeling template (Tzourio‐Mazoyer et al 2002) for each individual. Each regional mean time series was decomposed into wavelet coefficients at four scales using the maximum overlap discrete wavelet transform, a time‐frequency transformation.…”

Section: Methodsmentioning

confidence: 99%

Naltrexone ameliorates functional network abnormalities in alcohol‐dependent individuals

et al. 2017

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Naltrexone, an opioid receptor antagonist, is commonly used as a relapse prevention medication in alcohol and opiate addiction, but its efficacy and the mechanisms underpinning its clinical usefulness are not well characterized. In the current study, we examined the effects of 50‐mg naltrexone compared with placebo on neural network changes associated with substance dependence in 21 alcohol and 36 poly‐drug‐dependent individuals compared with 36 healthy volunteers. Graph theoretic and network‐based statistical analysis of resting‐state functional magnetic resonance imaging (MRI) data revealed that alcohol‐dependent subjects had reduced functional connectivity of a dispersed network compared with both poly‐drug‐dependent and healthy subjects. Higher local efficiency was observed in both patient groups, indicating clustered and segregated network topology and information processing. Naltrexone normalized heightened local efficiency of the neural network in alcohol‐dependent individuals, to the same levels as healthy volunteers. Naltrexone failed to have an effect on the local efficiency in abstinent poly‐substance‐dependent individuals. Across groups, local efficiency was associated with substance, but no alcohol exposure implicating local efficiency as a potential premorbid risk factor in alcohol use disorders that can be ameliorated by naltrexone. These findings suggest one possible mechanism for the clinical effects of naltrexone, namely, the amelioration of disrupted network topology.

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Automated Anatomical Labeling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject Brain

Cited by 14,549 publications

References 32 publications

Increased basal ganglia binding of ¹⁸F‐AV‐1451 in patients with progressive supranuclear palsy

Increased basal ganglia binding of ¹⁸F‐AV‐1451 in patients with progressive supranuclear palsy

Spatiotemporal dynamics in human visual cortex rapidly encode the emotional content of faces

Naltrexone ameliorates functional network abnormalities in alcohol‐dependent individuals

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Automated Anatomical Labeling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject Brain

Cited by 14,549 publications

References 32 publications

Increased basal ganglia binding of 18F‐AV‐1451 in patients with progressive supranuclear palsy

Increased basal ganglia binding of 18F‐AV‐1451 in patients with progressive supranuclear palsy

Spatiotemporal dynamics in human visual cortex rapidly encode the emotional content of faces

Naltrexone ameliorates functional network abnormalities in alcohol‐dependent individuals

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Product

Resources

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Increased basal ganglia binding of ¹⁸F‐AV‐1451 in patients with progressive supranuclear palsy

Increased basal ganglia binding of ¹⁸F‐AV‐1451 in patients with progressive supranuclear palsy