Automated analytical systems for drug development studies 3. Multivessel dissolution testing system based on microdialysis sampling

Microdialysis for evaluating the entrapment and release of a lipophilic drug from nanoparticles

“…Nowadays, its application has been extended to monitor local concentrations of drugs and metabolites in different organs and biological fluids, such as muscle, liver, bile, kidney, blood, skin, tumor and lung in animals and humans [17]. The in vitro microdialysis sampling has been used to determine protein binding of drugs [19,20], partition coefficient [21] and to sample dissolution testing of pharmaceutical formulations [22,23]. Up to now, this technique has not been proposed for studying colloidal systems physicochemical characteristics.…”

Analytical Considerations for Microdialysis Sampling

“…Microdialysis has several advantages as a monitoring system for dissolution studies [213] . First, it is possible to monitor the concentration of drug in solution continuously without having to remove aliquots from the apparatus, thereby disturbing the equilibrium [214,215] . Second, by coupling microdialysis online to the analytical system, it is possible to obtain the dissolution profi le in near real -time.…”

“…Microdialysis has also been used to investigate the dissolution of sustainedrelease pharmaceuticals such as Accutrim [215] . Dash et al used microdialysis sampling to investigate the dissolution of implantable drug delivery systems using ciprofl oxacin microcapsules in poly(lactic acid) (PLA) and poly(lacticglycolic acid) (PLGA) as a model system [216] .…”

Development of an in vitro dissolution method using microdialysis sampling technique for implantable drug delivery systems

“…[5][6][7] In vitro microdialysis sampling technique has also been used to determine the protein binding of a drug, 8,9 partition coefficient, 10 and dissolution testing of pharmaceutical formulations. 11,12 The overall goal of this study is to develop an in vitro dissolution method using a microdialysis sampling technique to study the release characteristics of drugs from implantable dosage forms and compare the in vitro release profiles obtained from an established USP dissolution method. The idea of microdialysis is to mimic the passive function of a capillary blood vessel by perfusing a perfusate solution through a thin dialysis tube implanted in the tissue near the site of the implant.…”