Automated analytical systems for drug development studies part IV. A microdialysis system to study the partitioning of lomefloxacin across an erythrocyte membrane in vitro

Microdialysis for evaluating the entrapment and release of a lipophilic drug from nanoparticles

“…Nowadays, its application has been extended to monitor local concentrations of drugs and metabolites in different organs and biological fluids, such as muscle, liver, bile, kidney, blood, skin, tumor and lung in animals and humans [17]. The in vitro microdialysis sampling has been used to determine protein binding of drugs [19,20], partition coefficient [21] and to sample dissolution testing of pharmaceutical formulations [22,23]. Up to now, this technique has not been proposed for studying colloidal systems physicochemical characteristics.…”

A Fast and reliable spectroscopic method for the determination of membrane‐water partition coefficients of organic compounds

“…To overcome this problem, alternative systems have been developed to model the partitioning of a molecule into a lipid phase. Among these, polymer-water, micelle-water and cell-water, as well as systems using artificial membranes, such as immobilized artificial membranes or liposome suspensions, have been developed (2)(3)(4)(5)(6)(7)(8)(9). Those with liposome suspensions not only present a good correlation with the behavior observed in membranes but also are easy to prepare and to handle.…”

Preparation and evaluation of lyophilized liposome-encapsulated bufadienolides

“…Microdialysis is an in vivo technique that permits monitoring of unbound tissue concentrations of drugs and metabolites at specific sites in the body 8 . The in vitro microdialysis sampling has been used to determine the partition coefficient 9 , protein binding of drugs 10,11 , and release profile of pharmaceutical formulations 12,13 . In this work, the microdialysis technique has been used to determine the EE of bufadienolide-loaded liposome (BU-lipo).…”