Automated analytical systems for drug development studies. I — A system for the determination of drug stability

Shah, Ketan P.; Zhou, Jianxun; Lee, R.; Schowen, Richard L.; Elsbernd, R.; Ault, Joseph M.; Stobaugh, John F.; Slavik, Michael F.; Riley, Christopher M.

doi:10.1016/0731-7085(94)e0011-o

Cited by 17 publications

(5 citation statements)

References 1 publication

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“…Shah et al76 developed a reaction system for automated exposure of compounds to the physical conditions: temperature, pH, and ionic strength. Kinetics assessment can be obtained using the system, and cycle time can be 0.2 to 200 min or more.…”

Section: High Throughput Physicochemical Profiling Methodsmentioning

confidence: 99%

High throughput physicochemical profiling for drug discovery

Kerns¹

2001

Journal of Pharmaceutical Sciences

326

194

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Section: High Throughput Physicochemical Profiling Methodsmentioning

confidence: 99%

High throughput physicochemical profiling for drug discovery

Kerns¹

2001

Journal of Pharmaceutical Sciences

326

194

View full text Add to dashboard Cite

“…The subsequent analysis of the API can be conducted using an HPLC‐UV system. This technique has already been described for dissolution testing and appears to be a promising technique for dissolution in simple dissolution media such as water [46–49] …”

Section: Analytical Techniques To Measure the Dissolution Rate Of Nanmentioning

confidence: 99%

“…[44] Daniel Jünemann and Jennifer Dressman Dissolution testing of nanosized drugs described for dissolution testing and appears to be a promising technique for dissolution in simple dissolution media such as water. [46][47][48][49]…”

Section: Microdialysismentioning

confidence: 99%

Analytical methods for dissolution testing of nanosized drugs

Jünemann

Dressman

2012

Journal of Pharmacy and Pharmacology

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“…[1][2][3][4] At the drug discovery stage, when drug candidates are screened against biological targets, compounds need to have sufficient stability in the assay buffers for enzyme, receptor, or cell-based assays to reliably measure biological activity. 5,6 During oral dosing into living systems, compounds are challenged by acidic, basic, and enzymatic conditions in the gastrointestinal tract.…”

mentioning

confidence: 99%

Development and Application of an Automated Solution Stability Assay for Drug Discovery

Di¹,

Kerns²,

Hong³

et al. 2006

SLAS Discovery

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Screening of solution stability provides an early alert on potential liabilities of drug candidates so that strategies can be developed to overcome the challenges. A fully automated solution stability assay has been developed to accelerate traditional manual operation. The assay uses the advanced capabilities of a high-performance liquid chromatography instrument that is present in many pharmaceutical research laboratories. The samples are prepared automatically by a temperature-controlled autosampler. The samples are delivered to the stability matrices, mixed, incubated, and injected at selected time points during the reaction time course. This automated process occurs without operator intervention, thus allowing 96 experiments to be run with 0.5 h of a scientist's time compared to 8 h for the same study when performed manually. Automation not only eliminates the manual operation but also improves accuracy and throughput. The assay protocol has been optimized to achieve homogenous mixing and eliminate carryover. The assay is robust, flexible, and high throughput. It can be used to study stability for a large number of samples under multiple incubation conditions and has a wide range of applications in drug discovery and development, such as screening compound stability in biological assay media, obtaining a stability-pH profile, surveying compound stability in physiological fluids, and performing development forced degradation and excipient compatibility. (Journal of Biomolecular Screening 2006:40-47)

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Automated analytical systems for drug development studies. I — A system for the determination of drug stability

Cited by 17 publications

References 1 publication

High throughput physicochemical profiling for drug discovery

High throughput physicochemical profiling for drug discovery

Analytical methods for dissolution testing of nanosized drugs

Development and Application of an Automated Solution Stability Assay for Drug Discovery

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