Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: case report

Lendeckel, Stefan; Jödicke, Andreas; Christophis, P.; Heidinger, Kathrin; Wolff, Jan; Fraser, John K.; Hedrick, Marc H.; Berthold, Lars; Howaldt, Hans‐Peter

doi:10.1016/j.jcms.2004.06.002

Cited by 575 publications

(405 citation statements)

References 32 publications

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“…We decided to use ASCs mainly because of their great accessibility and low patient morbidity when compared with other mesenchymal cell sources such as bone marrow or periosteum. The in vitro, in vivo and clinical bone‐forming capacity of ASCs in combination with various scaffold materials have been reported by many authors 14, 20, 35, 36, 37, 38, 39, 40, 41. In this series, the flow cytometric characterization of the ASCs expanded in autologous serum corresponded to previously published results for ASCs 42, 43.…”

Section: Discussionsupporting

confidence: 86%

Cranioplasty with Adipose-Derived Stem Cells, Beta-Tricalcium Phosphate Granules and Supporting Mesh: Six-Year Clinical Follow-Up Results

Thesleff

Lehtimäki

Niskakangas

et al. 2017

Stem Cells Translational Medicine

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Several alternative techniques exist to reconstruct skull defects. The complication rate of the cranioplasty procedure is high and the search for optimal materials and techniques continues. To report long‐term results of patients who have received a cranioplasty using autologous adipose‐derived stem cells (ASCs) seeded on beta‐tricalcium phosphate (betaTCP) granules. Between 10/2008 and 3/2010, five cranioplasties were performed (four females, one male; average age 62.0 years) using ASCs, betaTCP granules and titanium or resorbable meshes. The average defect size was 8.1 × 6.7 cm2. Patients were followed both clinically and radiologically. The initial results were promising, with no serious complications. Nevertheless, in the long‐term follow‐up, three of the five patients were re‐operated due to graft related problems. Two patients showed marked resorption of the graft, which led to revision surgery. One patient developed a late infection (7.3 years post‐operative) that required revision surgery and removal of the graft. One patient had a successfully ossified graft, but was re‐operated due to recurrence of the meningioma 2.2 years post‐operatively. One patient had an uneventful clinical follow‐up, and the cosmetic result is satisfactory, even though skull x‐rays show hypodensity in the borders of the graft. Albeit no serious adverse events occurred, the 6‐year follow‐up results of the five cases are unsatisfactory. The clinical results are not superior to results achieved by conventional cranial repair methods. The use of stem cells in combination with betaTCP granules and supporting meshes in cranial defect reconstruction need to be studied further before continuing with clinical trials. Stem Cells Translational Medicine 2017;6:1576–1582

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Section: Discussionsupporting

confidence: 86%

Cranioplasty with Adipose-Derived Stem Cells, Beta-Tricalcium Phosphate Granules and Supporting Mesh: Six-Year Clinical Follow-Up Results

Thesleff

Lehtimäki

Niskakangas

et al. 2017

Stem Cells Translational Medicine

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“…By fostering collaborative relationships between teams from academia, biotechnology startups, and established biomaterial industry companies, the development of ASC-based regenerative medical therapies for cartilage and bone defects can be accomplished in compliance with existing federal and international regulatory requirements. Evidence already exists suggesting that these goals are feasible since the successful use of autologous ASCs to repair critical-sized craniofacial defects has been published as case reports in the clinical literature [52,58].…”

Section: Discussionmentioning

confidence: 99%

2010 Nicolas Andry Award: Multipotent Adult Stem Cells from Adipose Tissue for Musculoskeletal Tissue Engineering

Guilak

Estes

Diekman

et al. 2010

Clinical Orthopaedics &Amp; Related Research

141

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Background Cell-based therapies such as tissue engineering provide promising therapeutic possibilities to enhance the repair or regeneration of damaged or diseased tissues but are dependent on the availability and controlled manipulation of appropriate cell sources. Questions/purposes The goal of this study was to test the hypothesis that adult subcutaneous fat contains stem cells with multilineage potential and to determine the influence of specific soluble mediators and biomaterial scaffolds on their differentiation into musculoskeletal phenotypes. Methods We reviewed recent studies showing the stemlike characteristics and multipotency of adipose-derived stem cells (ASCs), and their potential application in cellbased therapies in orthopaedics.

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“…120 As both adults and children over the age of two years are unable to correct large cranial defects due to inadequate ossification, this application has direct relevance in man and was first used to correct a 120-cm 2 defect in a seven-year-old girl with a severe head injury. 121 The differentiation of ADSCs into myocytes is relatively inefficient and gives a low yield and low reproducibility. 89 Glucocorticoids and 5% horse serum are used to supplement the growth media to stimulate the fusion of cells to form multi-nucleated myotubes which express myocyte markers.…”

Section: Adiposity and Insulin Resistance As A Biological Advantagementioning

confidence: 99%

Once fat was fat and that was that : our changing perspectives on adipose tissue

Ferris

Crowther

2011

CardioVascular Journal of Africa

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Past civilisations saw excess body fat as a symbol of wealth and prosperity as the general population struggled with food shortages and famine. Nowadays it is recognised that obesity is associated with co-morbidities such as cardiovascular disease and diabetes. Our views on the roll of adipose tissue have also changed, from being solely a passive energy store, to an important endocrine organ that modulates metabolism, immunity and satiety. The relationship between increased visceral adiposity and obesity-related co-morbidities has lead to the recognition that variation in fat distribution contributes to ethnic differences in the prevalence of obesity-related diseases. Our current negative view of adipose tissue may change with the use of pluripotent adipose-derived stromal cells, which may lead to future autologous stem cell therapies for bone, muscle, cardiac and cartilage disorders. Here, we briefly review the concepts that adipose tissue is an endocrine organ, that differences in body fat distribution underline the aetiology of obesity-related co-morbidities, and the use of adipose-derived stem cells for future therapies.

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Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: case report

Cited by 575 publications

References 32 publications

Cranioplasty with Adipose-Derived Stem Cells, Beta-Tricalcium Phosphate Granules and Supporting Mesh: Six-Year Clinical Follow-Up Results

Cranioplasty with Adipose-Derived Stem Cells, Beta-Tricalcium Phosphate Granules and Supporting Mesh: Six-Year Clinical Follow-Up Results

2010 Nicolas Andry Award: Multipotent Adult Stem Cells from Adipose Tissue for Musculoskeletal Tissue Engineering

Once fat was fat and that was that : our changing perspectives on adipose tissue

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