Autologous Skin-Grafting Surgery to Prevent Esophageal Stenosis After Complete Circular Endoscopic Submucosal Tunnel Dissection for Superficial Esophageal Neoplasms

Abstract

OBJECTIVES: To assess the safety and effectiveness of autologous skin-grafting surgery (ASGS) for preventing esophageal stenosis after complete circular endoscopic submucosal tunnel dissection (ccESTD) for superficial esophageal neoplasms. METHODS: Between October 2017 and March 2018, 8 patients who underwent ccESTD and ASGS were included. We assessed the occurrence of esophageal stenosis and adverse events. RESULTS: No adverse events occurred, including perforation, bleeding, wound infection, or stent migration. Five patients did not experience stenosis over a median follow-up of 7 months. CONCLUSIONS: ASGS appeared to be a safe and effective way to prevent esophageal stenosis after ccESTD.

Autologous esophageal mucosa with polyglycolic acid transplantation and temporary stent implantation for the prevention of esophageal stenosis after circumferential endoscopic submucosal dissection

“…To the best of our knowledge, [6][7][8] this is the first reported application of autologous esophageal mucosa with PGA transplantation and temporary stent implantation to prevent post-ESD esophageal stenosis. However, further follow-up of this case is required to determine the longterm efficacy of this technique in preventing postoperative esophageal stenosis.…”

“…Recently, some researchers reported transplantation of autologous gastric mucosa 5 or skin. 6 However, the gastric antral mucosa can secrete gastric acid, which may cause symptoms or even ulceration. The skin may secrete sweat.…”

Advances in the prevention and treatment of esophageal stricture after endoscopic submucosal dissection of early esophageal cancer

“…Liao et al [87] Chai et al [88] Physical and chemical components of the natural extracellular matrix Tissue accessibility…”

“…Chai et al [88] conducted a study that included eight patients who underwent complete circular endoscopic submucosal tunnel dissection (ccESTD). Skin grafts were collected from the lateral right thigh, used to cover the surface of an FCMS, placed into the esophagus, and fixed with clips.…”

Strategies to prevent stricture after esophageal endoscopic submucosal dissection

“…Chai et al (79,80) were the first to perform autologous skingrafting surgery (ASGS) to prevent esophageal stenosis after ESTD. In their study, a skin graft was harvested from the right outer thigh of the patient to sew into an oversleevelike skin with an absorbable suture.…”