Autologous serum skin test vs autologous plasma skin test in patients with chronic urticaria: evaluation of reproducibility, sensitivity and specificity and relationship with disease activity, quality of life and anti-thyroid antibodies

Kocatürk, Emek; Kavala, Mukaddes; Kural, Esra; Sarigul, Sukran; Zindancı, İlkin

doi:10.1684/ejd.2011.1294

Cited by 26 publications

(26 citation statements)

References 30 publications

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“…In addition, recent studies reported positive and negative ASST showed no significant difference in accordance with laboratory and urticaria disease severity [132836]. Our result in this study was similar to the study by Kocatürk et al [37] reporting no significant difference between positive ASST/negative APST and positive APST/negative ASST patients regarding disease duration, urticaria activity scores and DLQI scores.…”

Section: Discussionsupporting

confidence: 90%

Autologous serum and plasma skin test to predict 2-year outcome in chronic spontaneous urticaria

Boonpiyathad

Sangasapaviliya

2016

Asia Pacific Allergy

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BackgroundAutologous serum skin test (ASST) and autologous plasma skin test (APST) are simple methods to diagnose autoimmune chronic urticaria. However, the association data of ASST or APST with disease severity and long-term outcome are still unclear.ObjectiveThe results of ASST and APST might be used to predict urticaria symptom severity and long-term outcomes among chronic spontaneous urticaria (CSU) patients.MethodsWe evaluated the prevalence of reactive ASST and APST in 128 CSU patients. The patients were characterized by 4 groups: negative, ASST positive, APST positive, and both ASST and APST positive. We observed remission rate among the CSU patients during 2 years.ResultsForty-four of 128 CSU patients (34%) had negative autologous skin test. The CSU patients with positive ASST, positive APST, and both positive ASST and APST were 47 (37%), 6 (5%), and 31 (24%), respectively. No significant difference was found between the groups according to urticaria severity score (USS) and dermatology life quality index (DLQI). Mean wheal diameter of ASST showed positive correlation with DLQI. Also, mean wheal diameter of APST showed positive correlation with USS and DLQI. Both the positive ASST and APST groups had a high proportion of 4-fold dose of H1-antihistamine than the positive ASST (p = 0.03) and negative groups (p = 0.0009). The rate of remission over 2 years in the negative, positive ASST, positive APST, and both positive ASST and APST groups were 81.1%, 62.3%, 60%, and 46.1%, respectively. The urticaria remission rate in patients in the negative group was significantly higher compared with both positive ASST and APST groups (odds ratio, 5.0; 95% confidence interval, 1.61–15.44; p = 0.006).ConclusionASST and APST results could predict remission rates among patients with CSU. Our results suggested investigating ASST and APST among CSU patients before starting treatment.

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Section: Discussionsupporting

confidence: 90%

Autologous serum and plasma skin test to predict 2-year outcome in chronic spontaneous urticaria

Boonpiyathad

Sangasapaviliya

2016

Asia Pacific Allergy

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“…described APST and suggested it to be more sensitive than ASST,[18] which has been refuted by few researchers, claiming the higher rate of APST positivity in earlier studies being attributed to the failure to use negative control tests. [2028293031323334] In our study, we found no significant correlations between ASST and APST positivity with respect to gender, disease duration, and personal or family history of atopy, which coincides with the findings of previous studies. [2830]…”

Section: Discussionsupporting

confidence: 92%

“…[162829] In our study, the positive prevalence of autologous tests was 78% for ASST and 90% for APST, which is comparatively higher than most of the studies so far. Kocatürk et al .,[20] found that the specificity of ASST and APST was similar, whereas ASST was found to be more sensitive than APST in discriminating between CSU patients and controls. However, in our study we found APST to be more sensitive and specific than ASST with a higher positive predictive value, although it was not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

“…[1620] Patients were advised to stop antihistamines, doxepin, and steroids 2 days, 1 week, and 3 weeks prior to the test, respectively.…”

Section: Methodsmentioning

confidence: 99%

“…[1718] All relevant studies so far have reported that both the APST and ASST can be used for diagnostic purposes in patients with chronic autoimmune urticaria (CAU). [1620] Which of these is more sensitive and whether or not their positivity correlates with the disease severity, varies between different studies and cannot be decisively concluded.…”

Section: Introductionmentioning

confidence: 99%

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Autologous serum and plasma skin tests in chronic spontaneous urticaria: A reappraisal

Kumaran

Mangal

Narang

et al. 2017

Indian Dermatol Online J

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Aim:The objective of this study was to assess autologous serum skin test (ASST) vs autologous plasma skin test (APST) response in chronic spontaneous urticaria (CSU) patients and study the significance of intensity of positive responses in relation to clinicoepidemiological parameters.Materials and Methods:One hundred CSU patients and 100 age and sex-matched controls were recruited. The demographic and clinical features were recorded in all patients and routine investigations were performed. ASST and APST tests were performed as per the standard guidelines.Results:The mean duration of illness was 4.85 ± 5.07 years, 90% patients were APST (+), 68% ASST (+), and 22 patients were only APST (+). Positive predictive value (PPV) of ASST and APST was 90.7% and 95.7%, respectively. A significant inverse association was seen between thyroid status and serum IgE levels with APST and ASST positivity.Conclusion:APST appears to have better PPV and high intensity of positive response on autologous tests, and correlates with ANA positivity and angioedema.

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Urticaria

Zhao

Gao

2019

Advances in Integrative Dermatology

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Autologous serum skin test vs autologous plasma skin test in patients with chronic urticaria: evaluation of reproducibility, sensitivity and specificity and relationship with disease activity, quality of life and anti-thyroid antibodies

Cited by 26 publications

References 30 publications

Autologous serum and plasma skin test to predict 2-year outcome in chronic spontaneous urticaria

Autologous serum and plasma skin test to predict 2-year outcome in chronic spontaneous urticaria

Autologous serum and plasma skin tests in chronic spontaneous urticaria: A reappraisal

Urticaria

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