Autologous serum eye drops for dry eye

Pan, Qing; Angelina, Adla; Marrone, Michael; Stark, Walter J.; Akpek, Esen K.

doi:10.1002/14651858.cd009327.pub3

Cited by 92 publications

(127 citation statements)

References 99 publications

(302 reference statements)

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“…However, it is not clear whether NGF is beneficial or detrimental in DE. Autologous serum tears, a common treatment for recalcitrant DE, contain many growth factors including NGF; its beneficial effects on symptoms and signs of disease is believe to be partially mediated by NGF [61, 62]. …”

Section: Shared Molecular Mechanisms Between Ocular Dryness Pain Anmentioning

confidence: 99%

Neuropathic symptoms of the ocular surface: dryness, pain, and itch

Andersen

Yosipovitch

2017

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review To describe recent findings on epidemiology, pathophysiology and management of neuropathic symptoms of the ocular surface, with a focus on potential similarities between sensations of dry eye, pain and itch. Recent findings A narrative review of the literature was undertaken. Key references from research in dry eye, neuropathic symptoms of the ocular surface, ocular pain and itch as well as general references on itch and pain neurobiology were included. Recent findings suggest aspects of DE, chronic ocular pain, and itch symptomatology is driven by neuropathic pain mechanisms involving peripheral and central sensitization processes. Summary Ocular dryness, pain, and itch are prevalent complaints with several of shared features. Multiple lines of evidence suggest that peripheral and central neuronal sensitization processes are involved in generating and maintaining ocular sensory symptoms. Research is warranted on the epidemiology of ocular sensations, molecular mechanisms involved in nociception and pruriception in the eye, electrophysiological alterations in animal models of eye conditions, and therapeutic modalities that can alleviate unpleasant ocular sensations.

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Section: Shared Molecular Mechanisms Between Ocular Dryness Pain Anmentioning

confidence: 99%

Neuropathic symptoms of the ocular surface: dryness, pain, and itch

Andersen

Yosipovitch

2017

Current Opinion in Allergy &Amp; Clinical Immunology

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“…18 The review authors identified four RCTs examining a total of only 72 patients with dry eye of various etiologies (Sjögren’s-related, non-Sjögren’s related, and dry eye induced by laser-assisted in-situ keratomileusis [LASIK]), and concluded that there was inconsistency in the possible benefits of autologous serum. 18 …”

Section: Resultsmentioning

confidence: 99%

Gaps in Current Knowledge and Priorities for Future Research in Dry Eye

Saldanha

Dickersin

Hutfless

et al. 2017

Cornea

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Purpose Dry eye, a common, yet under-recognized and evolving field, has few recommended treatment algorithms, mostly based on expert consensus rather than robust research evidence. There are high costs associated with managing dry eye and conducting research to identify effective and safe long-term treatments. To support evidence-based management of dry eye, our purpose was to identify and prioritize important clinical research questions for future clinical research. Methods We translated recommendations from the American Academy of Ophthalmology’s 2013 Preferred Practice Patterns for dry eye into answerable clinical research questions about treatment effectiveness. Clinicians around the world who manage patients with dry eye rated each question’s importance from 0 (not important) to 10 (very important) using a two-round online Delphi survey. We considered questions as “important” if ≥75% of respondents assigned a rating of 6 or more in Round 2. We mapped the identified important clinical research questions to reliable systematic reviews published up to March 2016. Results Seventy-five clinicians from at least 21 countries completed both Delphi rounds. Among the 58 questions, 24 questions met our definition of “important”: 9/24 and 7/24 addressed topical and systemic treatments, respectively. All four questions with the highest 25th percentiles addressed topical treatments. While 6/24 “important” questions were associated with four existing reliable systematic reviews, none of these reviews came to a definitive conclusion about treatment effectiveness. Conclusion We identified gaps pertaining to treatment options for dry eye. Future clinical research on the management of dry eye should strongly consider these prioritized questions.

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“…A Cochrane review on the use of SED in adults with dry eye was published in 2017 12 and summarised the results of five RCTs (Celebi et al, 13 Kojima et al, 14 NodaTsuruya et al, 15 Tananuvat et al, 16 and Urzua et al 17 ). They concluded that SED 20% may provide some benefit in improving patient-reported symptoms in the short term (2 weeks), but that there appears to be no evidence of improvement over a longer period.…”

Section: ++mentioning

confidence: 99%