Autologous Retinal Transplantation with the Use of Air Tamponade for the Treatment of a Primary Large Chronic Macular Hole

Mota, Sergio E. Hernández-Da

doi:10.1159/000512388

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…Retinal graft can also be the primary option for large, chronic holes. [ 33 34 35 ] Despite being a free graft, it gets incorporated in the surrounding tissue with excellent perfusion[ 19 ] and recovery of physiological function, as seen by improved retinal sensitivity at the fovea on Humphrey visual field test (HVF) and improved responses on the mfERG in our two cases. Lumi et al .…”

Section: Discussionmentioning

confidence: 99%

Comparison of three techniques of harvesting full-thickness retinal tissue for large or persistent macular holes

Dhami

Biswas

Dogra

et al. 2022

Indian Journal of Ophthalmology

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Purpose: To evaluate the success rate of autologous retinal graft (ARG) for the closure of full-thickness macular holes (MHs) and compare the outcomes of three different techniques of harvesting the graft. Methods: Clinic files of all patients who had undergone ARG for MH using intraocular scissors, membrane loop, or retinal punch to harvest retinal tissue were retrospectively reviewed. All patients were evaluated for MH closure, retinal reattachment, and visual improvement. Results: Twenty-two eyes of 22 patients were included. ARG was done for 16 eyes (72.7%) with failed, large persistent MH, and six eyes (27.3%) also underwent simultaneous repair of retinal detachment. The basal diameter of MH was 1103.67 ± 310.09 (range 650–1529) mm. Intraocular scissors were used in 10 eyes (45.5%), a membrane loop in five eyes (22.7%), and a retinal punch in seven eyes (31.8%). Silicone oil tamponade was used in seven (31.8%) eyes and gas in 15 (68.1%) eyes. The follow-up ranged from 6 to 18 months. The hole closure rate was 72.7% (16/22). Visual improvement was noted in 18 eyes (81.8%). Retinal reattachment was seen in all eyes. Good graft integration with the surrounding area was seen in 17 eyes (77.3%). Graft retraction was seen in four eyes (18.18%) and graft loss in one eye (4.55%). No significant differences were noted among the three groups. Conclusion: ARG is successful in closing large, failed MH with and without retinal detachment. A membrane loop and retinal punch are equally useful in harvesting the graft, but scissors are preferable in case the retina is detached. With all three techniques, integration of the graft with the surrounding tissue can be achieved.

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Section: Discussionmentioning

confidence: 99%

Comparison of three techniques of harvesting full-thickness retinal tissue for large or persistent macular holes

Dhami

Biswas

Dogra

et al. 2022

Indian Journal of Ophthalmology

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Logbook of a Retinal Autograft

Güven¹,

Gül²,

Yılmaz³

et al. 2022

tjo

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This study aimed to evaluate the prognosis of a retinal autograft that was used to treat a macular hole that occurred after repeated vitreoretinal surgeries. A patient underwent repeated vitreoretinal surgery due to retinal detachment in the right eye, and the internal limiting membrane was also removed during the surgeries. After silicone oil removal, the patient developed recurrent retinal detachment and macular hole, and for this reason a retinal autograft was applied to the macular hole and silicone tamponade was administered. The silicone oil was removed at postoperative 7 months, and the macular hole was observed to be closed on fundus examination at 18 months. The final visual acuity was 5/100. On optical coherence tomography (OCT), the hole in the detached retina was measured as 600 μm in diameter preoperatively, 1020 μm on the first postoperative day, gradually narrowed to 765 μm, and graft integration occurred. During follow-up, the accumulation of hyperreflective spots persisted on the inner surface of the graft tissue and in all vertically extending sections. In en face sections, it appeared as a hyperreflective arc between the graft and host retina with a shadowing artefact. In OCT angiography evaluation, a punctate multiple blood flow signal in the vertical axis of the graft was detected in the early phase at 3 months. This finding persisted at 1 month after silicone removal, and the flow signal disappeared with resorption of the cystic edema. These flow signals were in the same location as the areas of hyperreflective spots on structural OCT. In conclusion, structural OCT and OCT angiography are effective methods for the follow-up of retinal autograft integration into host tissue.

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Autologous Retinal Transplantation with the Use of Air Tamponade for the Treatment of a Primary Large Chronic Macular Hole

Cited by 2 publications

References 10 publications

Comparison of three techniques of harvesting full-thickness retinal tissue for large or persistent macular holes

Comparison of three techniques of harvesting full-thickness retinal tissue for large or persistent macular holes

Logbook of a Retinal Autograft

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