Autologous Retina Transplantation for Treatment of Refractory Double Full-Thickness Macular Hole in Alport Syndrome

Abstract

Supplemental Digital Content is Available in the Text.To report the structural and functional outcomes of autologous neurosensory retinal transplantation for closure of refractory double full-thickness macular hole in a patient diagnosed with Alport syndrome during one year of follow-up.

Platelet-rich plasma and macular hole surgery: A clue to their mode of action and the influence of anti-platelet agents

“…Recently, a favourable outcome has been reported in a patient with previous failed macular hole surgery (ILM peel) in Alport syndrome undergoing PPV and autologous neurosensory retinal flap transplantation with silicone oil tamponade. 4 However, in our case aPRP was considered the technique of choice in this monocular patient, as it reportedly offers favourable functional outcomes for the treatment of refractory FTMH among the options available. 5 Platelet granules are known to be rich in trophic GFs which support wound-healing and tissue remodelling, and promote the migration and proliferation of Müller cells.…”

Sealed Unilateral Full-Thickness Macular Hole with Amniotic Membrane Graft in a Patient with Alport Syndrome: A Case Report

“…There are several cases of full-thickness MH and bilateral giant MH in patients with Alport syndrome where no intervention was offered to the patients [4,[8][9][10]. Vitrectomy, ILM peeling, and intraocular tamponade are the standard treatment options for MH repair, but in the case of thinned or missing ILM and adherent posterior hyaloid, such as in Alport patients, standard MH surgery can be unsuccessful [11][12][13][14]. The abnormal vitreoretinal interface and weakened basement membrane contribute to surgical intervention failure [6,12].…”

“…Since the posterior hyaloid was very adherent in that case, careful separation of the posterior hyaloid with an extrusion needle with high aspiration, and retinal forceps to peel the ILM beyond the vascular arcade has shown successful closure 1 month after the surgery with VA of 20/60 [ 7 ]. Sanjuan et al [ 13 ] reported a case of refractory full-thickness MH in a patient with Alport syndrome treated with vitrectomy combined with autologous neurosensory retinal flap and achieved anatomical closure of the MH with BCVA improved from 20/200 to 20/80.…”