Autologous Platelet-Rich Plasma Treatment Enables Pregnancy for a Woman in Premature Menopause

Abstract

This report presents the case of a woman aged 40 who has experienced premature menopause from the age of 35. Having rejected oocyte donation, she opted for intraovarian injection of autologous platelet-rich plasma with the aim to rejuvenate the ovarian tissue and enable the employment of her own gametes through in-vitro fertilization. Six weeks following the autologous platelet-rich plasma treatment, a significant reduction in the patient’s follicle-stimulating hormone (FSH) levels were noted. A natural in-vitro fertilization cycle led to a biochemical pregnancy, resulting in a spontaneous abortion at the 5th week of pregnancy. This is the first report of a successful autologous platelet-rich plasma application leading to pregnancy in menopause. This report uniquely contributes to the medical knowledge and challenges current practice in the context of infertility. The efficiency and safety of this treatment with regard to the reproductive system merits further investigation.

Live Birth in Woman With Premature Ovarian Insufficiency Receiving Ovarian Administration of Platelet-Rich Plasma (PRP) in Combination With Gonadotropin: A Case Report

“…Previous study proposed that PRP might enhance neoangiogenesis of menopausal status ovary and might promote the development of ovarian stem cells to mature follicles (10,11). In the present study, intraovarian PRP/Gn administration appeared to restore the follicular development in antral, early antral, and preantral stages.…”

“…Intraovarian PRP administration is a new therapeutic approach for patients with POI (21); however, the effect of PRP on regeneration of ovarian function does not seem to be optimistic, as only a handful of reports claimed a successful outcome (10,11). In the present study, intraovarian PRP/Gn administration resulted in a successful pregnancy that gave rise to a live birth in a POI patient who used to be an extremely poor responder to exogenous gonadotropins.…”

“…As there was no previous information on the issue of intraovarian injection of Gn, we were more cautious of overdosage and used one vial of pergoveris that contained 150 IU of rFSH and 75 IU of rLH. The volume of PRP for intraovarian administration was done according to previous reports, and approximately 4 mL PRP per ovary was employed for the intraovarian injection (10,17). After the PRP treatment, a 4mm follicle was detected on day 4.…”

“…Evidence from in vitro studies shows that PRP supports the viability and growth of human early pre-antral follicles (9). Direct injection of PRP into the stroma of poor responder ovaries leads to an increase in the number of follicles and eggs retrieved (10,11). To date, only one case of biochemical pregnancy was reported in a woman with POI after treatment with PRP (12).…”

Effects of intraovarian injection of autologous platelet rich plasma on ovarian reserve and IVF outcome parameters in women with primary ovarian insufficiency

“…They reported improvement in the laboratory parameters after intraovarian PRP in four women with DOR. Subsequently, Sfakianoudis et al reported the first pregnancy in a menopausal woman after intraovarian PRP injection [20]. This was a 40-year-old woman diagnosed with POI at the age of 35.…”