Autologous Platelet-Rich Plasma (PRP) in Infertility—Infusion versus Injectable PRP

Abstract

(1) Background: During IVF (in vitro fertilization) procedures, endometrial thickness has a significant role in the success of pregnancy outcomes for embryo transfers. Endometrial thickness, a crucial component of endometrial receptivity, is a contentious issue. The regenerative properties of PRP have been shown in recent research to have positive effects on the endometrium. PRP increases the pregnancy rate in IVF patients with thin endometrium and recurrent implantation failure. In order to demonstrate the efficacy of PRP therapies, this work compares the administration of injectable and infusible PRP during endometrial preparation. (2) Methods: This prospective single-arm control study was conducted at an IVF center in Oradea, Romania. This study included 50 patients; 27 were included in the group with Injectable PRP and 23 in the group with Infusible PRP. The outcome was compared between the two groups, with the primary outcome being the endometrial thickness after the PRP infusion or injection and the secondary outcome being the pregnancy rate in both groups. (3) Results: Patients who were treated with Injectable PRP had a higher pregnancy rate. An improvement in the quality of the endometrium, in terms of thickness, was also observed in the patients who were injected with PRP. (4) Conclusions: Compared to PRP infusions inside the uterus, sub-endometrial PRP injections in frozen embryo transfer methods have a greater pregnancy rate.

Effects of Adding Extracorporeal Shockwave Therapy (ESWT) to Platelet-Rich Plasma (PRP) among Patients with Rotator Cuff Partial Tear: A Prospective Randomized Comparative Study

“…PRP is a concentrated solution of platelets that is rich in growth factors, showing the ability to facilitate angiogenesis, neuroprotection, neural regeneration, regulation of inflammation with broad therapeutic applications [17,[32][33][34][35][36][37][38][39][40][41][42]. Comparative studies have shown the clinical advantages of PRP injection for patients with incomplete RC tears.…”

“…The Constant-Murley score (CMS) is a standardized scale for evaluating shoulder function, with a maximum score of 100 denoting optimal shoulder function. This scoring system has been employed in numerous studies for evaluating shoulder-related outcomes [4,[16][17][18]. Shoulder ROM was evaluated with the patient seated.…”

Intrauterine Infusion and Hysteroscopic Injection of Autologous Platelet-Rich Plasma for Patients with a Persistent Thin Endometrium: A Prospective Case–Control Study

“…In an in vitro study, active PRP stimulated the migration of human endometrial epithelial cells, stromal fibroblasts, and mesenchymal stem cells, and additionally, activated PRP increased the proliferation of endometrial stromal cells and mesenchymal cells [21]. PRP increased the EM thickness and improved the EM receptivity through the effect of cytokine regeneration [22]. The first report on the intrauterine infusion of autologous PRP for patients with persistent thin EM was published in 2015, demonstrating the efficacy of PRP treatment in increasing EM thickness and improving pregnancy rates after FET [23].…”