Autologous Platelet-Rich Plasma for Clitoral Reconstruction: A Case Study

Manin, Emily; Taraschi, G; Berndt, Sarah; Tejada, Begoña Martínez de; Abdulcadir, Jasmine

doi:10.1007/s10508-021-02172-9

Cited by 5 publications

(2 citation statements)

References 28 publications

(45 reference statements)

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“…After surgical clitoris reconstruction with the Foldès method, an A-PRP was applied. Two months postoperatively, wound healing was complete and the patient reported significant improvement in quality of life [34].…”

Section: Wound Healing and Tissue Regenerationmentioning

confidence: 90%

Platelet Rich Plasma in Gynecology—Discovering Undiscovered—Review

Streit-Ciećkiewicz

Kołodyńska

Futyma-Gąbka

et al. 2022

IJERPH

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Regenerative medicine combines elements of tissue engineering and molecular biology aiming to support the regeneration and repair processes of damaged tissues, cells and organs. The most commonly used preparation in regenerative medicine is platelet rich plasma (PRP) containing numerous growth factors present in platelet granularities. This therapy is increasingly used in various fields of medicine. This article is a review of literature on the use of PRP in gynecology and obstetrics. There is no doubt that the released growth factors and proteins have a beneficial effect on wound healing and regeneration processes. So far, its widest application is in reproductive medicine, especially in cases of thin endometrium, Asherman’s syndrome, or premature ovarian failure (POF) but also in wound healing and lower urinary tract symptoms (LUTS), such as urinary incontinence or recurrent genitourinary fistula auxiliary treatment. Further research is, however, needed to confirm the effectiveness and the possibility of its application in many other disorders.

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Section: Wound Healing and Tissue Regenerationmentioning

confidence: 90%

Platelet Rich Plasma in Gynecology—Discovering Undiscovered—Review

Streit-Ciećkiewicz

Kołodyńska

Futyma-Gąbka

et al. 2022

IJERPH

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“…Supplement Data S1: PubMed search syntax and search string; Supplement Data S2: Reference list of all excluded studies with reasons for exclusion; Supplement Data S3: Risk of bias of RCTs; Supplement Data S4: Risk of bias in non-RCTs. References [13,47,[57][58][59][60][61][62][63][64][65][66][67][68][69][70] are cited in the supplementary materials.…”

Section: Supplementary Materialsmentioning

confidence: 99%

Efficacy and Safety of Platelet-Rich Plasma Injections for the Treatment of Female Sexual Dysfunction and Stress Urinary Incontinence: A Systematic Review

Dankova,

Pyrgidis,

Tishukov

et al. 2023

Biomedicines

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Introduction: There is no clear evidence in the literature that platelet-rich plasma (PRP) injections improve female sexual dysfunction (FSD) and female stress urinary incontinence (SUI). Objectives: A systematic review was performed to study the efficacy and safety of PRP injections in women with the above pathologies, as well as to explore the optimal dosing, frequency and area of injections, and duration of treatment. Methods: A systematic search on PubMed, Embase and the Cochrane Library database was performed, as well as sources of grey literature from the date of database or source creation to January 2023. After title/abstract and full-text screening, clinical studies on humans evaluating the efficacy of PRP in gynecological disorders using standardized tools were included. Risk of bias was undertaken with RoB-2 for randomized-controlled trials (RCT) and the Newcastle-Ottawa Scale (NOS) for observational studies. Results: Four prospective and one retrospective study explored FSD, while six prospective and one RCT evaluated female SUI. A total of 327 women with a mean age of 51 ± 12 years were included. For FSD, PRP significantly improved the Female Sexual Function Index (FSFI), the Vaginal Health Index (VHI) and the Female Sexual Distress score (FSDS). For SUI, PRP led to a significant improvement in the International Consultation on Incontinence Questionnaire—Short Form (ICIQ-SF) and the Urogenital Distress Inventory (UDI-6). The identified RCT reported a significantly higher mean score of ICIQ-SF (p < 0.05) and UDI-6 (p < 0.01) in the midurethral sling group compared to the PRP injections group. Regarding the risk of bias, the RCT was characterized by high risk, whereas the observational studies were of moderate risk. The protocol for PRP injections for FSD is the injection of 2 mL of PRP into the distal anterior vaginal wall once a month for 3 months. For female SUI, 5–6 mL of PRP should be injected into the periurethral area once a month for 3 months. Conclusions: Despite the promising initial results of PRP injections, the level of current evidence is low due to methodological issues in the available studies. It becomes clear that there is an emerging need for high-quality research examining PRP injections for the treatment of FSD and female SUI.

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Autologous Platelet-Rich Plasma in Clitoral Reconstructive Surgery After Female Genital Mutilation/Cutting: A Pilot Case Study

Tognazzo

Berndt²,

Abdulcadir

2022

Aesthetic Surgery Journal

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Background Post-operative healing after clitoral reconstruction (CR) for Female Genital Mutilation/Cutting (FGM/C) can be long and painful due to prolonged clitoral re-epithelialization time (3 months). Autologous Platelet-Rich Plasma (A-PRP) might reduce post operative clitoral epithelialization time and pain. Objectives We assessed post-op clitoral re epithelialization time and pain after the use of intraoperative clitoral administration of A-PRP. Methods Five consecutive women underwent CR (Foldès technique) followed by the administration of A-PRP Regen Lab SA (Le Mont-sur-Lausanne, Switzerland) plasma and glue, respectively injected inside and applied above the re-exposed clitoris. We recorded surgical complications, post-operative clitoral pain (VAS), painkiller intake, time to complete re epithelialization and the experienced subjective changes in sexual response and perception of their own body image referred by women. Results Sexual distress/dysfunction as well as the desire to be physically and symbolically “repaired” were the reasons behind women’s requests for surgery. None of the women suffered from chronic vulvar or non-vulvar pain. All women achieved complete clitoral epithelialization by day 80. Three between day 54 and 70. Only one woman was still taking 1 g of Paracetamol twice a day at two-months post-op. She had stopped it before the three-month control. We did not have short nor long term complications. All women described easier access and stimulation of their clitoris, improved sexual arousal, lubrication, and pleasure, and said to be satisfied of their restored body image. Conclusions A-PRP could expedite post-op clitoral epithelialization and reduce post op pain after CR after FGM/C.

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Autologous Platelet-Rich Plasma for Clitoral Reconstruction: A Case Study

Cited by 5 publications

References 28 publications

Platelet Rich Plasma in Gynecology—Discovering Undiscovered—Review

Platelet Rich Plasma in Gynecology—Discovering Undiscovered—Review

Efficacy and Safety of Platelet-Rich Plasma Injections for the Treatment of Female Sexual Dysfunction and Stress Urinary Incontinence: A Systematic Review

Autologous Platelet-Rich Plasma in Clitoral Reconstructive Surgery After Female Genital Mutilation/Cutting: A Pilot Case Study

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