Autologous Platelet Gel to Treat Chronic Decubital Ulcers: A Randomized, Blind Controlled Clinical Trial in Dogs

Tambella, Adolfo Maria; Attili, Annarita; Dini, Fabrizio; Piccionello, Angela Palumbo; Vullo, Cecilia; Serri, Evelina; Scrollavezza, Paolo; Dupré, Gilles

doi:10.1111/j.1532-950x.2014.12148.x

Cited by 40 publications

(50 citation statements)

References 47 publications

(111 reference statements)

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“…Among the hemocomponents, PRP is a good adjunctive therapy for the treatment of orthopedic and soft tissue conditions [3, 6, 7, 13, 17, 18, 20]. Non-unions, bone defects, tendinosis and cartilage defects are among musculoskeletal conditions lacking effective treatment modalities, and regenerative medicine may play an important role.…”

mentioning

confidence: 99%

Use of autologous platelet-rich plasma for a delayed consolidation of a tibial fracture in a young donkey

Faillace

Tambella

Fratini

et al. 2017

The Journal of Veterinary Medical Science

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A 9-month-old filly donkey was referred for a comminuted diaphyseal fracture of the right tibia. Surgical osteosynthesis, with multiple lag screws and a neutralization plate, was performed for anatomical reconstruction. Despite a good gait condition, delayed bone consolidation and a bone gap were evident on follow up radiographic evaluations. Due to delayed healing, autologous platelet-rich plasma (PRP) was injected on the surface of the tibia. Increased bone consolidation was evident on radiographs one month after the PRP injection. Progressive filling of both the fracture lines and bone gap continued during the six-month follow up. Clinical outcome was excellent. Autologous PRP should be considered as a practical adjuvant therapy in bone healing process in donkeys.

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confidence: 99%

Use of autologous platelet-rich plasma for a delayed consolidation of a tibial fracture in a young donkey

Faillace

Tambella

Fratini

et al. 2017

The Journal of Veterinary Medical Science

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“…Gel derived from PRP has been shown to speed healing of chronic decubital ulcers in dogs compared to controls with paraffin-impregnated gauze. 26 …”

Section: Topical Productsmentioning

confidence: 99%

Principles of Wound Management and Wound Healing in Exotic Pets

Mickelson

Mans

Colopy

2016

Veterinary Clinics of North America: Exotic Animal Practice

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Synopsis The care of wounds in exotic animal species can be a challenging endeavor. Special considerations must be made in regards to the animal’s temperament and behavior, unique anatomy and small size, and tendency towards secondary stress-related health problems. It is important to assess the entire patient with adequate systemic evaluation and consideration of proper nutrition and husbandry, which could ultimately impact wound healing. This article summarizes the general phases of wound healing, factors that impact healing, and principles of wound management. Emphasis is placed on novel methods of treating wounds and species differences in wound management and healing.

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“…In recent years, many products and innovative techniques for increasing the quality and speed of wound healing have been investigated. Topical treatments include hyaluronic acid, growth factors and blood components, stem cells, and adipose‐derived stromal vascular fraction as well as negative‐pressure wound therapy, ozone therapy, electrical stimulation, ultrasound, and phototherapy . The variety of tested therapies highlights the level of interest in improving the healing of cutaneous lesions because of their frequency and potential challenging consequences.…”

Section: Introductionmentioning

confidence: 99%

Effect of the topical Klox fluorescence biomodulation system on the healing of canine surgical wounds

et al. 2020

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Objective:To determine the effect of the Klox fluorescence biomodulation system (Phovia) on the healing of surgical wounds.Study design: Prospective, blinded, controlled clinical trial. Sample population: Healthy dogs undergoing orthopedic surgery (n = 10).Methods: Half of the length of each surgical wound was treated with Phovia, and the remaining 50% was treated with saline solution on the first day after surgery and every 3 days until day 13. Wound healing of treated and control areas within each wound was evaluated via macroscopic assessment and histological and immunohistochemical analysis of treated and control wounds.Results: The areas treated with Phovia achieved lower histology scores (P = .001), consistent with complete re-epithelialization, less inflammation of the dermal layer, and greater and more regular deposition of collagen.According to immunohistochemistry, expression of factor VIII, epidural growth factor, decorin, collagen III, and Ki67 was increased in treated compared with untreated tissues. Conclusion: Phovia therapy improved re-epithelialization, decreased dermal inflammation, and improved matrix formation in uncomplicated cutaneous incisional wounds by regulating the expression of key biological mediators. Clinical significance: Phovia may be a beneficial adjunct to promote the healing of incisional wounds.

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Autologous Platelet Gel to Treat Chronic Decubital Ulcers: A Randomized, Blind Controlled Clinical Trial in Dogs

Abstract: Appropriately prepared autologous PG, an inexpensive, readily available blood derivative, applied topically results in more rapid healing of chronic non-healing decubital ulcers in dogs than those treated by use of paraffin-impregnated gauzes.

Cited by 40 publications

References 47 publications

Use of autologous platelet-rich plasma for a delayed consolidation of a tibial fracture in a young donkey

Use of autologous platelet-rich plasma for a delayed consolidation of a tibial fracture in a young donkey

Principles of Wound Management and Wound Healing in Exotic Pets

Effect of the topical Klox fluorescence biomodulation system on the healing of canine surgical wounds

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