Autologous peripheral blood progenitor cells are a potential source of parvovirus B19 infection

Abstract

Autologous PBPCs are a potential source of parvovirus infection, which may cause significant disease after autologous BMT.

Exposure of hematologic patients to parvovirus B19 as a contaminant of blood cell preparations and blood products

“…Thus, immunity to the transferred virus should be assumed, but antibody production is usually highly impaired in the first months after PBPC or BMT, 36 and symptomatic infection by this transmission route has been described. 23,37 In both allogeneic and autologous PBPCs, transmission of parvovirus B19 cannot be avoided by donor selection. Therefore, recipients from IgG-positive PBPC donors should be monitored for B19 DNA in serum.…”

Replication of influenza A virus in swine umbilical cord epithelial stem-like cells

“…Earlier studies indicated that stem cell derived from hepatitis B and C-, cytomegalovirus (CMV)-, human herpesvirus 6-, and parvovirus-infected donors transmitted these infections in the recipients. [46][47][48][49][50][51] Since stem cells possess immunomodulatory and differentiation properties and are being tested to treat autoimmune and inflammatory diseases, influenza virus infection of these cells may affect their engraftment in recipients and alter their differentiation and immunomodulatory properties and thereby, may adversely influence the outcome of the transplantation. Currently, the data addressing these questions are not available.…”

Pure Red Cell Aplasia due to B19 Parvovirus Infection after Autologous Stem Cell Transplantation

“…There is a limited number of papers of PRCA due to parvovirus infection after auto-SCT [14–16]. In conclusion, PRCA due to parvovirus B19 infection is a rare complication following auto-SCT presumably due to the faster immunologic recovery in comparison with allo-SCT or solid-organ transplantation.…”