Autologous ovarian platelet rich plasma treatment improves oocyte and embryo quality: a before-after prospective study

Parvanov, Dimitar; Ganeva, Rumiana; Vidolova, Nina; Nikolova, Kristina; Vasileva, Magdalena; Totev, T; Stamenov, Georgi

doi:10.1080/13102818.2022.2090280

Cited by 8 publications

(4 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We, and the previous study, conclude that there is a clear need for future controlled studies to identify patients who benefit most from PRP administration ( 28 , 23 , 40 , 41 , 42 , 43 ).…”

Section: Discussionmentioning

confidence: 58%

“…Navali et al ( 40 ) showed that a single intra-ovarian of PRP injection is associated with an elevation in the number of oocytes and embryos although further evidence is required to assess the influence of PRP on the live birth rate.. Parvanov et al ( 41 ) revealed that using ovarian PRP in poor responders may be associated with a significant improvement in oocyte and embryo quality. However, the results of Tulek et al ( 42 ) study showed that intra-ovarian injection of PRP do not increase live birth rates or clinical pregnancy rates in poor responder women.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

How Does Platelet-rich Plasma Injection in Ovaries of Poor Responders Affect the Retrieved Oocytes, and Anti Mullerian Hormone: A Clinical Trial

Tehraninejad,

Razavi,

Menshadi

et al. 2023

JFRH

View full text Add to dashboard Cite

Objective: Platelet Rich Plasma (PRP) is proposed to have important role in cell division and proliferation, angiogenesis and health. This study evaluates the effect of a single injection of autologous PRP on ovarian response markers in women with poor ovarian response (POR). Materials and methods: This non-randomized clinical trial was conducted between August 2020 and September 2021. Fifty six women with Bologna criteria for POR willingly chose to participate in one of the following groups: PRP for one cycle in the time of oocyte pickup (OPU) (intervention group, n= 34) or control group (n=22).The primary outcomes were: number and quality of oocytes in coming 2 cycles of ICSI, and Anti Mullerian Hormone (AMH) level two months after PRP injection. The secondary outcomes were the number and quality of embryos and chemical pregnancy rate after embryo transfer. Results: A total of 45 participants continued the study, of which 23 were in the intervention group and 22 in control group. There were no demographic differences between two groups. At a two cycle follow up, PRP group experienced a significant improvement in AMH level and there was no respective change in control group. In one year follow up the overall pregnancy rates were same in both groups (3% Vs. 0, p=.60), while there was no difference in cumulative number and quality of embryos. Conclusion: PRP injection can improve ovarian reserve marker without adverse effects. Further evidence is required to evaluate the impact of PRP on assisted reproduction outcomes.

show abstract

Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

How Does Platelet-rich Plasma Injection in Ovaries of Poor Responders Affect the Retrieved Oocytes, and Anti Mullerian Hormone: A Clinical Trial

Tehraninejad,

Razavi,

Menshadi

et al. 2023

JFRH

View full text Add to dashboard Cite

show abstract

“…The sample size of these studies ranged from 12 to 510, add up to 793 POR patients. Among the 10 trials included, 5 were treated for 2 months ( 3 , 32 , 38 , 40 , 41 ), 3 for 3 months ( 37 , 42 , 43 ), 1 study for 2-3 months ( 36 ), and 1 study for 6 months ( 39 ). Three studies injected PRP doses≥4ml per ovary ( 32 , 37 , 40 ), seven studies injected PRP doses <4ml per ovary ( 3 , 36 , 38 , 39 , 41 – 43 ), and ten studies used self-control studies ( 3 , 32 , 36 – 43 ).…”

Section: Resultsmentioning

confidence: 99%

The effect of ovarian injection of autologous platelet rich plasma in patients with poor ovarian responder: a systematic review and meta-analysis

Li,

Liu,

Lin

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

ObjectiveTo evaluate the effects of ovarian injection of autologous platelet rich plasma (aPRP) on patients with poor ovarian responder (POR) based on the existing clinical evidence.MethodsAccording to systematic review and meta-analysis, we comprehensively searched nine databases established as of September 6, 2023, and evaluated the impact of ovarian PRP infusion on poor ovarian responder. The research results include serum follicle-stimulating hormone(FSH) and anti-Mullerian hormone(AMH) levels, antral Follicle Count(AFC), oocyte number, and embryo number. The Newcastle Ottawa Scale (NOS) was used to evaluate the quality of inclusion in trials.ResultsAdd up to 10 studies consisting of 793 participants were included in the meta-analysis. A review of existing evidence showed that intraovarian injection of PRP has significant therapeutic effects in increasing levels of anti-Müllerian hormone (AMH) (SMD=0.44,95% CI [0.07,0.81], p=0.02), antral follicle count (AFC) (MD=1.15,95% CI [0.4,1.90], p=0.003), oocyte count (MD=0.91, 95% CI [0.40, 1.41], p=0.0004), and embryo number (MD=0.78, 95% CI [0.5,1.07], p<0.0001). We compared the relevant data of patients before and after treatment after 2 months of intervention. It can be seen that ovarian injection of PRP treatment for 2 months has better effects in reducing FSH levels, increasing AMH levels, increasing antral follicle count, and increasing the number of oocytes and embryos (p<0.05). When the dose of PRP injected into each ovary was ≥ 4ml, there was also a significant correlation (p<0.05) with improving the number of AFC, oocytes and embryos. Significant heterogeneity existed among the studies.ConclusionThe pooled results suggest that intra-ovarian injection of PRP can promote ovarian regeneration and improve the reproductive outcomes of patients with ovarian dysfunction. This therapy may have significant clinical potential in improving sex hormone levels, increasing AFC, oocyte count, and embryo count. However, this findings still requires more rigorous and extensive trials worldwide to determine the value of intra-ovarian injection of PRP in POR patients.Systematic review registrationhttps://www.crd.york.ac.uk, Identifier CRD42023451232.

show abstract

“…Similarly, a study by Parvanov et al demonstrated a notable rise in the count of successfully retrieved MII oocytes as well as the number of blastocysts following PRP treatment. Additionally, they observed enhanced quality of oocytes and embryos in approximately 75% of patients who underwent PRP ovarian treatment [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Enhancement of Ovarian Reserve and Oocyte Quality After Platelet-Rich Plasma Instillation in a Woman With Diminished Anti-Müllerian Hormone

Shrivastava,

More,

Shrivastava

et al. 2024

Cureus

View full text Add to dashboard Cite

Platelet-rich plasma (PRP) is a concentrated platelet preparation known for its regenerative properties due to the various growth factors it contains. Its application in the medical field, including dentistry, gynecology, and plastic surgery, has surged. In obstetrics and gynecology, PRP has shown promise in improving low libido, vaginal rejuvenation, ovarian reserve, and endometrial receptivity. This study presents a 29-year-old woman experiencing primary infertility attributed to low levels of anti-Müllerian hormone alongside the presence of asthenozoospermia in her husband’s semen. After failed intrauterine insemination as well as in vitro fertilization (IVF), attempts at laparoscopic PRP treatment were administered before the second IVF cycle to enhance ovarian reserve and quality. The PRP treatment led to an increased follicle count, improved oocyte quality, and a successful pregnancy outcome in the second IVF cycle. PRP treatment promises to be effective in fertility treatments, potentially increasing ovarian reserve, improving oocyte quality, and enhancing successful pregnancy outcomes. This case report highlights its beneficial impact on a couple facing primary infertility, providing hope for patients with similar reproductive challenges.

show abstract

Autologous ovarian platelet rich plasma treatment improves oocyte and embryo quality: a before-after prospective study

Cited by 8 publications

References 26 publications

How Does Platelet-rich Plasma Injection in Ovaries of Poor Responders Affect the Retrieved Oocytes, and Anti Mullerian Hormone: A Clinical Trial

How Does Platelet-rich Plasma Injection in Ovaries of Poor Responders Affect the Retrieved Oocytes, and Anti Mullerian Hormone: A Clinical Trial

The effect of ovarian injection of autologous platelet rich plasma in patients with poor ovarian responder: a systematic review and meta-analysis

Enhancement of Ovarian Reserve and Oocyte Quality After Platelet-Rich Plasma Instillation in a Woman With Diminished Anti-Müllerian Hormone

Contact Info

Product

Resources

About