Autologous myoblasts attenuate atrophy and improve tongue force in a denervated tongue model: A pilot study

Abstract

N/A.

Novel murine xenograft model for the evaluation of stem cell therapy for profound dysphagia

“…Muscle fiber diameter was larger in GFP+ myofibers, suggesting attenuation of muscle atrophy and providing evidence of new muscle formation. Furthermore, there was a 27% increase in maximal tongue contractile force and a 54% increase in maximum tongue base pressure . To translate these large animal MDSC histologic and functional outcomes to the clinic, human MDSC therapy needed to be evaluated.…”

The quasi-parallel lives of satellite cells and atrophying muscle

“…We focus in this paragraph on acquired muscle wasting conditions. Recent observations suggest that a cell transplantation approach could be useful in reducing muscle loss after hind limb suspension and denervation (Plowman et al, 2014 ; Kim et al, 2015 ). Importantly, it has been reported that transplantation of SCs attached to their myofiber coupled with muscle injury could prevent the loss of muscle mass associated with aging (Hall et al, 2010 ).…”

Improved adductor function after canine recurrent laryngeal nerve injury and repair using muscle progenitor cells

“…[6][7][8] Plowman et al reported attenuation of atrophy, increased myofiber diameter, and increased maximal contraction force after implantation of MPCs into partially denervated sheep tongues. 9 Halum et al have successfully cultured MPCs from rat skeletal muscle and implanted them into denervated thyroarytenoid muscles. They found the injected MPCs survived in their new muscle, attenuated atrophy, fused with the native myofibers, and enhanced reinnervation when programmed to express neurotrophic factor.…”