Autologous mixed lymphocyte reaction in man

Autologous Mixed Lymphocyte Reaction in Health and Disease States in Man

“…However, this would not exclude the likelihood that T cells forming rosettes with autologous or allogeneic RBC would have a specific function. The ARFT cells have been shown by several groups to con tain autoreactive T cells in AMLR [34,94,103,129]. However, more recently Kumagai et al [82] and Sakane et al [106] described nonautologous rosette-forming T cells as major responders in AMLR and found that ARFT cells do not respond in AMLR.…”

Autologous mixed lymphocyte reaction in the peripheral blood and pleural effusions of cancer patients.

“…It has recently been demonstrated that T cells forming rosettes with autologous erythrocytes proliferate in response to autologous non-T cells in AMLR (18,19,30 This study has demonstrated that the AMLR in carcinomatous pleural effusions is comparable to or even higher than that in the peripheral blood of normal controls and that in nonmalignant pleural effusions of patients with congestive heart failure. Normal or higher levels of AMLR in malignant effusions is unlikely to be due to the contamination of tumor cells in the stimulator non-T cell population because effusion T cells responded to autologous blood non-T cells as strongly as to autologous effusion non-T cells.…”

“…It has been demonstrated that the AMLR provides a proliferative stimulus for the generation of cytotoxic T cells (11,30) and represents a defense mechanism against neoplastic transformation (12). Although the actual biological significance of the phenomenon is unclear, it may be important in host resistance against autologous tumor cells.…”

Defective Self-Recognition in Subjects of Far-Advanced Age

“…Moreover, no sex differences were observed concerning au tologous MLR in either young or old sub jects. Our results are in accordance with those of Fernandez and MacSween [1980] and of Moody ex al., [1981], However, a higher au tologous MLR in aged people, particularly in female subjects, has been reported by Four nier and Charreire [1981], It is interesting to note that Fournier and Charreire [1981] used total lymphocytes as responding cells. This technical modification presumably has a great relevance as far as the response in au tologous MLR is concerned.…”

“…More recently the proliferative response of T lymphocytes in the autologous MLR has also been found to be decreased with age [Fernandez and MacSween, 1980;, unlike Fournier and Charreire [1981] who found an increasing proliferative response in autologous MLR with age, partic ularly in female subjects.…”