Autologous microfragmented adipose tissue reduces inflammatory and catabolic markers in supraspinatus tendon cells derived from patients affected by rotator cuff tears

Amniotic membrane-mesenchymal stromal cells secreted factors and extracellular vesicle-miRNAs: Anti-inflammatory and regenerative features for musculoskeletal tissues

“…Regarding cartilage and tendon cells which are of particular interest in this study, the literature currently lacks functional in vitro tests directly assessing the ability of hAMSCs or their secretome to suppress inflammation and promote regenerative features such as restoring the baseline levels of altered matrix components (eg, collagen) or matrix modifying enzymes (eg, MMPs). Herein, in a model of inflammation relying on IL-1β and largely used to treat chondrocytes 114 and tenocytes, 115 we observed that hAMSC secretome was able to promote a trend toward restoration of homeostatic levels for both inflammation and ECM remodeling markers altered by the inflammatory stimulus. This is of crucial relevance since ECM alteration is orchestrated by both dysregulation of collagen deposition and structure and increase of MMPs which degrade major ECM structural components, such as aggrecan and collagen.…”

Osteoarthritis: an ancient disease, an unsolved conundrum

“…Anyway, our first challenge is a timely diagnosis: the identification of new diagnostic tools, both at genetic, biochemical and radiologic levels, will allow us to identify "high-risk" patients in order to provide them a timely treatment before disease progression. In recent years, there has been a growing interest towards serum and synovial biomarkers, with some promising data: this topic is well represented in our Special Issue, where the papers by Izaguirre et al [7] and Viganò et al [8] shed light on the role of cartilage degradation markers. Cartilage damage is recognized as the very first phase of OA, and, under a clinical point of view, it is fundamental to detect this stage before further worsening: to this purpose, the findings of the study by Cole et al [9] could be relevant to stimulate clinicians in not underestimating symptoms.…”

Why Use Adipose-Derived Mesenchymal Stem Cells in Tendinopathic Patients: A Systematic Review

“…The use of ASCs has emerged as a good candidate for tendon healing due to their properties promoting proliferation and tenogenic differentiation [43][44][45]. These properties have been mostly investigated in musculoskeletal disorders [62], while the application in tendon disorders is mainly supported by pre-clinical evidence [45,[48][49][50][51][52]. Nevertheless, the efficacy of intratendinous ASCs injections was reported by all seven studies analyzed in the present review.…”

“…Therefore, the use of ASCs may be extremely useful in tendon regeneration and repair [42]. To date, however, the evidence supporting the use of ASCs in tendinopathies is still scarce and mostly based on in vivo and in vitro studies [45,[48][49][50][51][52]. Therefore, the aim of the present systematic review was to summarize the available clinical evidence that proposes and evaluates the application of ASCs in tendinopathies in order to give a clear overview of the present research and progress.…”