Autologous mesenchymal stem cells: clinical applications in amyotrophic lateral sclerosis

Mazzini, Letizia; Mareschi, Katia; Ferrero, Ivana; Vassallo, Elena; Oliveri, Giuseppe; Boccaletti, Riccardo; Testa, Lucia; Livigni, Sergio; Fagioli, Franca

doi:10.1179/016164106x116791

Cited by 173 publications

(104 citation statements)

References 20 publications

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“…Intraspinal autologous MSC application was used in seven amyotrophic lateral sclerosis patients in Italy. 60 No patient manifested major adverse events such as respiratory failure or death. Minor adverse events were intercostal pain irradiation and leg sensory dysesthesia, both reversible after a mean period of 6 weeks.…”

Section: Stem Cells In Cnsmentioning

confidence: 99%

Migration, fate and in vivo imaging of adult stem cells in the CNS

Syková

Jendelová

2007

Cell Death Differ

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Section: Stem Cells In Cnsmentioning

confidence: 99%

Migration, fate and in vivo imaging of adult stem cells in the CNS

Syková

Jendelová

2007

Cell Death Differ

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“…So far, MSCs have already been used in several clinical trials including neurological diseases and spinal injury (17,18), with results that have fallen short of any high expectations. It has been speculated that one of reasons was an insufficient knowledge of physiological behavior of MSCs.…”

mentioning

confidence: 99%

Mesenchymal Stem Cells Are Recruited into Wounded Skin and Contribute to Wound Repair by Transdifferentiation into Multiple Skin Cell Type

Sasaki

Abe

Fujita

et al. 2008

The Journal of Immunology

892

696

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Mesenchymal stem cells (MSCs) can differentiate not only into mesenchymal lineage cells but also into various other cell lineages. As MSCs can easily be isolated from bone marrow, they can be used in various tissue engineering strategies. In this study, we assessed whether MSCs can differentiate into multiple skin cell types including keratinocytes and contribute to wound repair. First, we found keratin 14-positive cells, presumed to be keratinocytes that transdifferentiated from MSCs in vitro. Next, we assessed whether MSCs can transdifferentiate into multiple skin cell types in vivo. At sites of mouse wounds that had been i.v. injected with MSCs derived from GFP transgenic mice, we detected GFP-positive cells associated with specific markers for keratinocytes, endothelial cells, and pericytes. Because MSCs are predominantly located in bone marrow, we investigated the main MSC recruitment mechanism. MSCs expressed several chemokine receptors; especially CCR7, which is a receptor of SLC/CCL21, that enhanced MSC migration. Finally, MSC-injected mice underwent rapid wound repaired. Furthermore, intradermal injection of SLC/CCL21 increased the migration of MSCs, which resulted in an even greater acceleration of wound repair. Taken together, we have demonstrated that MSCs contribute to wound repair via processes involving MSCs differentiation various cell components of the skin.

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“…A low (0.3 x 10 6 MSC/kg) and a high cell dose (0.6 x 10 6 MSC/kg) product was prepared and transferred to 1 cc syringes. When translated to a clinical setting, the above doses will be comparable to the infusion of 0.1 x 10 6 /kg to 2.5 x 10 6 MSC /kg, which is similar to the range of MSC utilized or proposed in clinical studies [21,[24][25][26].…”

Section: Cell Infusionmentioning

confidence: 96%

The Intrathecal Infusion of Mesenchymal Stem Cells into Healthy Rabbits is Safe and Devoid of Neurological or Clinical Complications

Jj¹,

Pereira²,

Bartholomew³

et al. 2011

J Stem Cell Res Ther

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Background: Cellular, molecular and transplantation studies using mouse and rat models of neurological diseases have revealed that Mesenchymal Stem Cells (MSC) represent a reliable candidate for cellular therapies for neurological conditions, including Amyotrophic Lateral Sclerosis (ALS) and Spinal Cord Injury (SCI). However, evaluation of safety aspects associated with route and dose of cell infusion, pivotal issues in cell therapy, has not been tested in large animals.

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Autologous mesenchymal stem cells: clinical applications in amyotrophic lateral sclerosis

Abstract: Our results demonstrate that direct injection of autologous expanded MSCs into the spinal cord of ALS patients is safe, with no significant acute or late toxicity, and well tolerated. The clinical results seem to be encouraging.

Cited by 173 publications

References 20 publications

Migration, fate and in vivo imaging of adult stem cells in the CNS

Migration, fate and in vivo imaging of adult stem cells in the CNS

Mesenchymal Stem Cells Are Recruited into Wounded Skin and Contribute to Wound Repair by Transdifferentiation into Multiple Skin Cell Type

The Intrathecal Infusion of Mesenchymal Stem Cells into Healthy Rabbits is Safe and Devoid of Neurological or Clinical Complications

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