Autologous Immune Complex Nephritis in Streptozotocin-Induced Diabetic Rats

Okuda, Seiya; Oh, Yukinori; Onoyama, Kaoru; Fujimi, Satoshi; Omae, Teruo

doi:10.1159/000183238

Cited by 4 publications

(4 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rao and Cresson [19] suggest that the complica tion of MGN in patients with diabetic glomerulosclerosis may aggrevate renal dysfunction requiring early dialysis or renal transplant. Okuda et al [17] reported that the mortality rate of the rats with Heymann nephritis compli cating streptozotocin-induced diabetes was higher than those with no complication. There are, however, no large series studies concerning the effects of the coexistence of superimposed GN on long-term prognosis in diabetic patients.…”

Section: Discussionmentioning

confidence: 99%

Glomerulonephritis in Diabetic Patients and Its Effect on the Prognosis

Chihara¹,

Takebayashi²,

Taguchi³

et al. 1986

Nephron

View full text Add to dashboard Cite

Renal biopsies were obtained from 164 patients with diabetes mellitus. Their histological changes were evaluated together with clinical findings and prognosis. In 36 patients, various types of glomerulonephritis were complicated: mesangial proliferative glomerulonephritis (17 patients), membranous glomerulonephritis (8), endocapillary proliferative glomerulonephritis (5), membranoproliferative glomerulonephritis (4) and minimal change nephrotic syndrome (2). Superimposed glomerulonephritis was suspected in diabetic patients with a short history of less than 5 years, persistent proteinuria, occasional hematuria and no retinopathy. They may, however, produce little effects on the long-term prognosis of diabetic patients except membranoproliferative glomerulonephritis.

show abstract

Section: Discussionmentioning

confidence: 99%

Glomerulonephritis in Diabetic Patients and Its Effect on the Prognosis

Chihara¹,

Takebayashi²,

Taguchi³

et al. 1986

Nephron

View full text Add to dashboard Cite

show abstract

“…Larger and more numerous immune complexes were seen in diabetic rats upon induction of Heymann nephritis than their nondiabetic counterparts. [21] Our patients with DPGN on a background of DN showed significantly worse outcomes compared to their nondiabetic counterparts; 85% required dialysis and the renal function did not return to baseline in any case. This was in sharp contrast to the nondiabetic adults with PIGN, who showed complete and partial recovery in 45% and 36% of cases respectively.…”

Section: Discussionmentioning

confidence: 68%

Rapidly Progressive Renal Failure in Type 2 Diabetes in the Tropical Environment: A Clinico-Pathological Study

et al. 2005

View full text Add to dashboard Cite

show abstract

“…First, electron microscopy showed that the amount of the subendothelial electron-dense deposits was greater in the PM-UN group than in the UN group. Okuda et al (1984) and Abrass and Cohen (1987) reported that diabetic rats with Heymann nephritis developed more intensely stained immune deposits along the capillary wall and mesangium than control rats with Heymann nephritis. Okuda et al explained this phenomenon by the contributions of three suggested mechanisms.…”

Section: Discussionmentioning

confidence: 99%

“…In experiments with rats, Okuda et al (1984) and Abrass and Cohen (1987) have found that the renal lesions produced by immunological insult of the glomeruli in diabetic rats were more severe than those produced in nondiabetic rats. They induced Heymann nephritis as a model of idiopathic membranous glomerulonephritis in streptozotocin-induced diabetic rats.…”

mentioning

confidence: 99%

Accelerated glomerulosclerosis in alloxan-induced diabetic rabbits with anti-glomerular basement membrane nephritis.

Wanibuchi

Fujimoto

Ueda

1991

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

To find how diabetes affects the processes of proliferative glomerulitis, we induced anti-glomerular basement membrane (GBM) nephritis by injection of anti-GBM antiserum in rabbits with alloxan diabetes (the DM-GN group) and in rabbits without the diabetes (the GN group), and compared the glomerular lesions between the two groups. Rabbits with alloxan diabetes only (the DM group) were also studied as control. Morphological examination showed that in the acute phase, the DM-GN and GN groups underwent histolysis of the glomerular loops, which gave rise to proliferative glomerulitis. In the later stages of glomerulitis, proliferating cells were crowded toward the axial portion of glomerular loops with an increase of intercellular matrix, and glomerular capillaries in the periphery of the glomerular loops recanalized. The amount of intercellular matrix of the axial portion increased more in the DM-GN group than in the GN group. Some of the glomerular lesions in the DM-GN group showed a formation of large nodules. The results suggested that diabetes could accelerate the formation of the intercellular matrix of glomerular loops in proliferative glomerulitis in rabbits, resulting in accelerated glomerulosclerosis.

show abstract

Autologous Immune Complex Nephritis in Streptozotocin-Induced Diabetic Rats

Cited by 4 publications

References 20 publications

Glomerulonephritis in Diabetic Patients and Its Effect on the Prognosis

Glomerulonephritis in Diabetic Patients and Its Effect on the Prognosis

Rapidly Progressive Renal Failure in Type 2 Diabetes in the Tropical Environment: A Clinico-Pathological Study

Accelerated glomerulosclerosis in alloxan-induced diabetic rabbits with anti-glomerular basement membrane nephritis.

Contact Info

Product

Resources

About