Autologous Hematopoietic Stem Cell Transplantation in Children With Severe Resistant Multiple Sclerosis

Киргизов, К. И.; Скоробогатова, Е. В.; Bembeeva, R.; Volkova, Ekaterina; Бологов, А. А.; Пилия, С. В.; Maschan, A.; Румянцев, А. Г.

doi:10.15690/vsp.v12i1.572

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…The European transplant centers applied mostly reduced intensity protocols. Before 2010, high-and medium-intensity regimens were mainly used, followed by later shift towards the use of cyclophosphamide-containing regimens, thus enabling implementation of this approach even in younger MS patients with under 18 years [55].…”

Section: Unresolved Issues In Conditioning Regimensmentioning

confidence: 99%

High-dose immunosuppressive therapy with autologous hematopoietic stem cells transplantation for multiple sclerosis: Current view

Polushin¹,

Lopatina²,

Zalyalov³

et al. 2022

CTT

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Autologous hematopoietic stem cells transplantation (aHSCT) followed by high-dose immunosuppressive therapy is a promising and effective method of treating autoimmune diseases, including multiple sclerosis (MS). Over the past 15-20 years, frequency and severity of adverse events in aHSCT were decreased after reducing the intensity of conditioning regimens. Both better understanding of the immunological mechanisms of immune reconstitution and better approach to the selection of patients for this procedure also led to improved results.In view of increased incidence of multiple sclerosis worldwide, as well as insufficient effectiveness of standard therapy, the introduction of autologous transplantation into clinical guidelines for the MS treatment could maintain quality of life in the workforce population.

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Section: Unresolved Issues In Conditioning Regimensmentioning

confidence: 99%

High-dose immunosuppressive therapy with autologous hematopoietic stem cells transplantation for multiple sclerosis: Current view

Polushin¹,

Lopatina²,

Zalyalov³

et al. 2022

CTT

View full text Add to dashboard Cite

show abstract

High-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation in multiple sclerosis: a modern view of the method (review of literature)

Polushin¹,

Zalyalov²,

Totolyan³

et al. 2022

The Scientific Notes of the Pavlov university

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РезюмеВ мире отмечается рост заболеваемости рассеянным склерозом. Лишь в половине случаев стандартная терапия позволяет на непродолжительное время добиваться контроля над этим заболеванием. Высокодозная иммуносупрессивная терапия с аутологичной трансплантацией гемопоэтических стволовых клеток является перспективным и эффективным методом лечения аутоиммунных заболеваний, в том числе рассеянного склероза. За последние 20 лет достигнут прогресс в понимании иммунных механизмов метода. Значимо уменьшена частота и выраженность нежелательных явлений терапии за счет снижения интенсивности режимов кондиционирования. Целью настоящего обзора является анализ научных публикаций, посвященных эффективности метода, данных по выбору оптимальных условий и критериев его применения при рассеянном склерозе.Ключевые слова: клиническая апробация, высокодозная иммуносупрессивная терапия, рассеянный склероз, гемопоэтические стволовые клетки, трансплантация, иммунотерапия, аферез, мобилизация

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Autologous Hematopoietic Stem Cell Transplantation in Children With Severe Resistant Multiple Sclerosis

Cited by 2 publications

References 9 publications

High-dose immunosuppressive therapy with autologous hematopoietic stem cells transplantation for multiple sclerosis: Current view

High-dose immunosuppressive therapy with autologous hematopoietic stem cells transplantation for multiple sclerosis: Current view

High-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation in multiple sclerosis: a modern view of the method (review of literature)

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