Autologous Fat Transfer for Esthetic Contouring of Face in Posttraumatic Nonfunctional Maxillofacial Deformities

Agrawal, Kapil; Bachhav, Manoj; Naik, Charudatta; Tanwar, Harshwardhan; Sankhe, Shilpa

doi:10.1055/s-0035-1566163

Cited by 16 publications

(16 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Fat grafting first gathered prominence in the aesthetic area (24), and subsequent study showed it had a favourable complication profile compared to synthetic filler materials (25,26).…”

Section: Autologous Fat Graftingapplications and Indications Of Autolmentioning

confidence: 99%

Autologous fat grafting in the face and neck-Multinational trends and knowledge of the safety, applications and indications considering oncologic risk potential

Fiedler¹,

Saleh²,

Mukrowsky³

2021

Preprint

View full text Add to dashboard Cite

Introduction Autologous fat grafting (AFG) has both aesthetic and reconstructive applications. Described by Neuber in 1893 there are numerous applications of AFG as the body of evidence for its use has expanded. The earliest controversies were evident in lipofilling for breast defects post-oncological treatment, and to this day some countries do not allow it for fear of inducing tumourogenesis in an oncologically ablated field. Adipose-derived stem cells (ASCs) have been shown pro-oncologic behaviour in xenografts, however, this has not been reproduced in clinical observations thus far. Material and Methods We sought to review contemporary harvesting and processing techniques for AFG in the craniofacial region, therefore distributed a survey to evaluate the opinion and clinical impact of oncological risk across four European countries with possibly differing clinical attitudes. Results In the craniofacial region AFG is mostly used for aesthetic indications, cannula hand-held aspiration and centrifugation seem to be the predominant harvesting and processing techniques. Half of our respondents tell patients about the possibility of pro-oncologic behaviour of AFG. We found no significant geographical differences between the German-speaking and the English groups concerning their harvesting and processing technique. German participants seem to perform AFG more often and mostly use it for cosmetic and post-cancer treatment sequelae, English participants homogenically use AFG for cosmetic reasons. Conclusion Theoretical pro-oncologic behaviour of craniofacial AFG does not deter surgeons. Perhaps, we shouldn’t consider discussing this complex area of oncogenesis with patients as there is no elevated risk from what we know.

show abstract

“…Fat grafting first gathered prominence in the aesthetic area (24), and subsequent study showed it had a favourable complication profile compared to synthetic filler materials (25,26).…”

Section: Autologous Fat Graftingapplications and Indications Of Autolmentioning

confidence: 99%

Autologous fat grafting in the face and neck-Multinational trends and knowledge of the safety, applications and indications considering oncologic risk potential

Fiedler¹,

Saleh²,

Mukrowsky³

2021

Preprint

View full text Add to dashboard Cite

show abstract

“…However, its therapeutic effects are not maintained over time, because it has an absorbable micromolecular structure. Autologous structural fat transplant is traditionally used for treating facial soft tissue depressions [1-3], and in addition to improving facial structure, it notably improves skin condition.…”

Section: Introductionmentioning

confidence: 99%

Precise Intradermal Injection of Nanofat-Derived Stromal Cells Combined with Platelet-Rich Fibrin Improves the Efficacy of Facial Skin Rejuvenation

Liang

Lü

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: The rejuvenation properties of nanofat grafting have been described in recent years. However, it is not clear whether the clinical efficacy of the procedure is attributable to stem cells or linked to other components of adipose tissue. In this study we isolated nanofat-derived stem cells (NFSCs) to observe their biological characteristics and evaluate the efficacy of precise intradermal injection of nanofat combined with platelet-rich fibrin (PRF) in patients undergoing facial rejuvenation treatment. Methods: Third-passage NFSCs were isolated and cultured using a mechanical emulsification method and their surface CD markers were analyzed by flow cytometry. The adipogenic and osteogenic nature and chondrogenic differentiation capacity of NFSCs were determined using Oil Red O staining, alizarin red staining, and Alcian blue staining, respectively. Paracrine function of NFSCs was evaluated by enzyme-linked immunosorbent assay (ELISA) at 1, 3, 7, 14, and 28 days after establishing the culture. Then, the effects of PRF on NFSC proliferation were assessed in vitro. Finally, we compared the outcome in 103 patients with facial skin aging who underwent both nanofat and intradermal PRF injection (treatment group) and 128 patients who underwent hyaluronic acid (HA) injection treatment (control group). Outcomes in the two groups were compared by assessing pictures taken at the same angle before and after treatment, postoperative recovery, incidence of local absorption and cysts, and skin quality before treatment, and at 1, 12, 24 months after treatment using the VISIA Skin Image Analyzer and a SOFT5.5 skin test instrument. Results: NFSCs expressed CD29, CD44, CD49d, CD73, CD90, and CD105, but did not express CD34, CD45, and CD106. NFSCs also differentiated into adipocytes, osteoblasts, and chondrocytes under appropriate induction conditions. NFSCs released large amounts of growth factors such as VEGF, bFGF, EGF, and others, and growth factor levels increased in a time-dependent manner. At the same time, PRF enhanced proliferation of NFSCs in vitro in a dose-dependent manner, and the growth curves under different concentrations of PRF all showed plateaus 6d after seeding. Facial skin texture was improved to a greater extent after combined injection of nanofat and PRF than after control injection of HA. The nanofat-PRF group had a higher satisfaction rate. Neither treatment caused any complications such as infection, anaphylaxis, or paresthesia during long-term follow-up. Conclusion: NFSCs demonstrate excellent multipotential differentiation and paracrine function, and PRF promotes proliferation of NFSCs during the early stage after seeding. Both nanofat-PRF and HA injection improve facial skin status without serious complications, but the former was associated with greater patient satisfaction, implying that nanofat-PRF injection is a safe, highly effective, and long-lasting method for skin rejuvenation.

show abstract

“…[1–4] Several factors can cause such disease, including cleft lip, cleft palate, cancer, trauma, and automobile accident. [5–11] It has been reported that about 20% of the world's population have some major OMDF. [12,13] It has greatly affected the health-related quality of life in patients with OMDF.…”

Section: Introductionmentioning

confidence: 99%

“…Surgery is a very effective treatment for patients with OMDF. [2,4,5,7,8,17–23] Although a variety of studies have reported the efficacy and safety of surgery, especially for orthodontic and orthognathic treatment (OOT) for the management of OMDF, there is still inconsistent conclusion. [2,4,18–22] Thus, this study will assess the efficacy and safety of OOT for the treatment of patients with OMDF.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of orthodontic and orthognathic treatment for oral and maxillofacial deformities

Gao

2019

Medicine

View full text Add to dashboard Cite

Background:This study aims to assess the efficacy and safety of orthodontic and orthognathic treatment (OOT) for patients with oral and maxillofacial deformities (OMDF) systematically.Methods:This study will comprehensively search Cochrane Library, PubMed, EMBASE, Scopus, Web of Science, PsycINFO, Index to Nursing and Allied Health Literature, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure from their inceptions to the July 1, 2019. Grey literature will be explored via searching dissertations, Google scholar and conference abstracts. Two team members will independently perform all citations, data extraction, and methodological quality. We will also utilize RevMan 5.3 Software for statistical analysis.Results:This study will provide high quality evidence of OOT for OMDF. The primary outcomes consist of number of patients cured; proportion of patients healed; and time to complete healing within trial period. Secondary outcomes include quality of life (often assessed as any relevant scales, such as 36-Item Short Form Survey), costs, and complications.Conclusion:This study will provide evidence for judging whether OOT is effective treatment for OMDF.Systematic review registration:CRD42019144610.

show abstract

Autologous Fat Transfer for Esthetic Contouring of Face in Posttraumatic Nonfunctional Maxillofacial Deformities

Cited by 16 publications

References 25 publications

Autologous fat grafting in the face and neck-Multinational trends and knowledge of the safety, applications and indications considering oncologic risk potential

Autologous fat grafting in the face and neck-Multinational trends and knowledge of the safety, applications and indications considering oncologic risk potential

Precise Intradermal Injection of Nanofat-Derived Stromal Cells Combined with Platelet-Rich Fibrin Improves the Efficacy of Facial Skin Rejuvenation

Efficacy of orthodontic and orthognathic treatment for oral and maxillofacial deformities

Contact Info

Product

Resources

About