Autologous Fat Injection versus Lundborg Resection Arthroplasty for the Treatment of Trapeziometacarpal Joint Osteoarthritis

Erne, H.; Černý, M; Ehrl, Denis; Bauer, Anna T.; Schmauss, Verena; Moog, Philipp; Broer, P. Niclas; Loew, Steffen; Schmauß, Daniel

doi:10.1097/prs.0000000000003913

Cited by 30 publications

(38 citation statements)

References 28 publications

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“…The development of new therapeutic strategies for the treatment of osteoarthritis is an active area of research. Recent human studies have demonstrated satisfactory results with the intra-articular administration of purified and micro-fragmented adipose tissue for the treatment of knee, 18,19 subtalar, 20 carpometacarpal 21,22 and thumb osteoarthritis. [23][24][25] In veterinary literature, a recent study 26 suggested clinical evidence of pain control over a period of up to 180 days with intra-articular administration of autologous purified and micro-fragmented adipose tissue for the treatment of osteoarthritis in dogs.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a Single Intra-Articular Injection of Autologous Adipose Tissue for the Treatment of Osteoarthritis: A Prospective Clinical Study in Dogs

Pavarotti

Hivernaud²,

Brincin

et al. 2020

Vet Comp Orthop Traumatol

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Objective The aim of this study was to investigate the safety, feasibility and clinical efficacy of a single intra-articular injection of autologous and purified micro-fragmented adipose tissue for the treatment of osteoarthritis (OA) in dogs. Study Design Twenty-one client-owned dogs with radiographically confirmed OA were recruited into this prospective study. Lameness and discomfort were evaluated by physical examination at day 0 and then 14, 30, 60 and 180 days after injection. Kinetic data and temporospatial parameters were obtained using a pressure-sensing walkway. Peak vertical force, vertical impulse and percentages of body weight distribution were determined. Owner perception data regarding their own dog's physical activity were also collected using the Canine Brief Pain Inventory. Results Radiographic scores for OA from days 0 to 180 were similar, except in two dogs. No major side effects were noted after injection. Lameness and Canine Brief Pain Inventory scores were significantly lower at all time points compared with day 0. Post-injection results demonstrated gradual improvement of kinetic data up to day 180 compared with pre-treatment values: vertical impulse (>2.25%), peak vertical force (>5.32%) and percentages of body weight distribution (>3.6%). In dogs with elbow OA, gait analysis values significantly increased at all time points compared with day 0. Conclusion Regenerative autologous adipose tissue injection therapy is a promising alternative to traditional analgesics treatment in patients with OA, associated with significant reductions in pain and lameness, delayed disease progression and improved quality of life.

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Section: Discussionmentioning

confidence: 99%

Evaluation of a Single Intra-Articular Injection of Autologous Adipose Tissue for the Treatment of Osteoarthritis: A Prospective Clinical Study in Dogs

Pavarotti

Hivernaud²,

Brincin

et al. 2020

Vet Comp Orthop Traumatol

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“…It was also found that time from surgery to absence of pain was shorter in the fat grafting group. 14 In addition, incision to suture time was also shorter in the fat grafting group. 14 Fat grafting into the CMC joint has also been combined with arthroscopic synovectomy in a small cohort of patients (12 subjects) with early stages of rhizarthrosis (I-II stages according to Eaton- Littler classification).…”

Section: Resultsmentioning

confidence: 91%

“… 14 In addition, incision to suture time was also shorter in the fat grafting group. 14 Fat grafting into the CMC joint has also been combined with arthroscopic synovectomy in a small cohort of patients (12 subjects) with early stages of rhizarthrosis (I-II stages according to Eaton- Littler classification). 15 In the former study the harvested fat tissue was only decanted but not centrifuged.…”

Section: Resultsmentioning

confidence: 91%

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Autologous fat transplantation for the treatment of trapeziometacarpal joint osteoarthritis

Alessandri‐Bonetti¹,

Rovere²,

Fulchignoni³

et al. 2020

Orthop Rev (Pavia)

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Rhizarthrosis is a progressive and disabling pathology affecting the carpometacarpal joint. It’s very common in elderly patients and typically affects postmenopausal women. The diagnosis of rhizarthrosis is mainly made by using different physical examination tests and by evaluating the type of pain and it’s then confirmed by imaging. Over the last few years increasing attention has been devoted to the assessment of new treatment techniques for rhizarthrosis. In this context intra-articular injection of autologous fat grafting for cartilage regeneration has demonstrated promising results in experimental settings as an alternative to open surgery procedures. The aim of this study was therefore to sum up the evidences available so far on autologous fat grafting as an emerging treatment for patients affected by carpometacarpal rizarthrosis. An electronic literature research was carried out on Pubmed, Google Scholars and Cochrane Library using “fat grafting”, “fat graft”, “adipose”, “fat transfer” and “lipoaspirate” as search terms. Authors believe autologous fat grafting is an interesting technique, that hand surgeon should keep in mind especially in early stages of rhizarthrosis were pain has not been solved with non-surgical treatment.

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“…As a consequence, it is important to evaluate new less invasive and nonablative techniques preserving the trapezium. 22 …”

Section: Discussionmentioning

confidence: 99%

Total Endoprosthesis Versus Lundborg´s Resection Arthroplasty for the Treatment of Trapeziometacarpal Joint Osteoarthritis

Erne

Scheiber²,

Schmauß

et al. 2018

Plastic and Reconstructive Surgery - Global Open

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Background:There exist various operative approaches for the treatment of trapeziometacarpal joint osteoarthritis. The aim of this study was to compare the results of Lundsborg’s resection arthroplasty (RA) with implantation of a total endoprosthesis.Patients and Methods:In this 2-center study, we retrospectively analyzed 71 patients with symptomatic osteoarthritis of the carpometacarpal I joint stage III according to the Eaton-Littler classification. Thirty-two patients underwent a Lundsborg’s RA group, and 39 patients received a total endoprosthesis of the carpometacarpal I joint (TEP group). We evaluated operative time, DASH score, postoperative time until resolution of symptoms, pain level, pinch force, and satisfaction with the treatment.Results:Both groups had a similar mean length of follow-up of 42 months (TEP group) and 36 months (RA group). The final DASH score was significantly better in the TEP-group (10.1 versus 21.5 in the RA group; P ≤ 0.05). Also, the time interval from surgery till absence of any pain (1.5 versus 5.9 months) and the time of inability to work (6 versus 21 weeks) were significantly shorter for the TEP group compared with the RA group (P ≤ 0.05). The pinch force, pain intensity, and the satisfaction with the treatment were comparable (P > 0.05). The duration of the operation was significantly shorter in the RA group (31 min versus 65 min in the TEP group; P ≤ 0.05).Conclusion:Both techniques resulted in improved function of the operated hand and a clear reduction of symptoms. However, the implantation of a total endoprosthesis seems to have advantages, given a significantly better DASH score and a significantly shorter time until resolution of symptoms.

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Autologous Fat Injection versus Lundborg Resection Arthroplasty for the Treatment of Trapeziometacarpal Joint Osteoarthritis

Abstract: Therapeutic, III.

Cited by 30 publications

References 28 publications

Evaluation of a Single Intra-Articular Injection of Autologous Adipose Tissue for the Treatment of Osteoarthritis: A Prospective Clinical Study in Dogs

Evaluation of a Single Intra-Articular Injection of Autologous Adipose Tissue for the Treatment of Osteoarthritis: A Prospective Clinical Study in Dogs

Autologous fat transplantation for the treatment of trapeziometacarpal joint osteoarthritis

Total Endoprosthesis Versus Lundborg´s Resection Arthroplasty for the Treatment of Trapeziometacarpal Joint Osteoarthritis

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