Autologous Fat Grafting

Ross, Richard J.; Shayan, Ramin; Mutimer, Keith L.; Ashton, Mark W.

doi:10.1097/sap.0b013e31827aeb51

Cited by 68 publications

(48 citation statements)

References 88 publications

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“…Reported graft retention rates vary from 10–90% (1–3). This has led to innovations ranging from minor modifications to lipofilling as described by Coleman, to the use of automated devices designed to preserve adipose tissue/cell integrity (4, 5).…”

Section: Introductionmentioning

confidence: 99%

Studies in Fat Grafting

Paik

Zielins

Atashroo

et al. 2015

Plastic and Reconstructive Surgery

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Background Cell-assisted lipotransfer has shown much promise as a technique to improve fat graft take. However, the concentration of stromal vascular fraction cells required to optimally enhance fat graft retention remains unknown. Methods Human lipoaspirate was processed for both fat transfer and harvest of stromal vascular fraction (SVF) cells. Cells were then mixed back with fat at varying concentrations ranging from 10,000 to 10 million cells per 200 µl of fat. Fat graft volume retention was assessed via CT scanning over 8 weeks, and then fat grafts were explanted and compared histologically for overall architecture and vascularity. Results Maximum fat graft retention was seen at a concentration of 10,000 cells per 200 µl of fat. The addition of higher number of cells negatively impacted fat graft retention, with supplementation of 10 million cells producing the lowest final volumes, lower than fat alone. Interestingly, fat grafts supplemented with 10,000 cells showed significantly increased vascularity and decreased inflammation, while fat grafts supplemented with 10 million cells showed significant lipodegeneration compared to fat alone Conclusions Our study demonstrates dose dependence in the number of SVF cells that can be added to a fat graft to enhance retention. While cell-assisted lipotransfer may help promote graft survival, this effect may need to be balanced with the increased metabolic load of added cells that may compete with adipocytes for nutrients during the post-graft period.

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Section: Introductionmentioning

confidence: 99%

Studies in Fat Grafting

Paik

Zielins

Atashroo

et al. 2015

Plastic and Reconstructive Surgery

View full text Add to dashboard Cite

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“…During weight loss, visceral fat is preferential lost, due to greater sensitivity to lipolytic stimulation signals (Joseph et al, 2002). This a process associated with improved insulin resistance (Ross et al, 2014). Bariatric surgery reduces both visceral and subcutaneous fat, leading to overall improved metabolic profiles (Rajabzadeh et al, 2019), however surgery to remove subcutaneous fat (liposuction or abdominoplasty) do not lead to improved metabolic profiles (Ross et al, 2014).…”

Section: Fat Grafting the Stromal Vascular Fraction And Adscsmentioning

confidence: 99%

“…This a process associated with improved insulin resistance (Ross et al, 2014). Bariatric surgery reduces both visceral and subcutaneous fat, leading to overall improved metabolic profiles (Rajabzadeh et al, 2019), however surgery to remove subcutaneous fat (liposuction or abdominoplasty) do not lead to improved metabolic profiles (Ross et al, 2014). The largest amount of visceral fat occurs at level of umbilicus and the greatest amount of subcutaneous fat is found in the region of the buttocks; however, these distributions may vary significantly with gender (Mizuno, 2009).…”

Section: Fat Grafting the Stromal Vascular Fraction And Adscsmentioning

confidence: 99%

“…The largest amount of visceral fat occurs at level of umbilicus and the greatest amount of subcutaneous fat is found in the region of the buttocks; however, these distributions may vary significantly with gender (Mizuno, 2009). The abdomen and buttocks are the most commonly used areas for fat harvest for fat graft surgery (Ross et al, 2014).…”

Section: Fat Grafting the Stromal Vascular Fraction And Adscsmentioning

confidence: 99%

“…By the 1980s, early rates of graft take [(approximately 50% (Illouz, 1986)] had failed to significantly improved, despite multiple technical refinements in graft harvest, centrifuge or infiltration (Carraway and Mellow, 1990). Irrespective of these loss rates, liposuction techniques using syringe harvest enhanced the popularity of fat grafting for correcting facial contour defects in the 1980s (Rohrich et al, 2004) and led to the introduction of fat grafting for the correction of soft tissue deficits in other body areas (Coleman, 2001;Yoshimura et al, 2008;Tabit et al, 2012;Ross et al, 2014) (Figures 1A, B). Nevertheless, significant numbers of patients who underwent fat grafting continued to suffer graft loss, and those in whom graft take was achieved endured up to 70% loss of volume Mizuno, 2009).…”

Section: The History and Evolution Of Fat Graftingmentioning

confidence: 99%

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