Autologous chondrocyte implantation for traumatic full-thickness cartilage defects of the knee in 14 patients: 6-year functional outcomes

Viste, Anthony; Piperno, M.; Desmarchelier, Romain; Grosclaude, Sophie; Moyen, B.; Fessy, Michel‐Henri

doi:10.1016/j.otsr.2012.04.019

Cited by 32 publications

(18 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A consensus was reached on the explicit classification of short-, mid-, and long-term follow-up. Based on current literature terminology for cartilage repair in the human knee, short term was defined to be follow-up from 1 to 4 years, [19][20][21][22][23] with mid-term defined as 5-8 years, [24][25][26][27][28] and long term as greater than 9 years. 15,17,[29][30][31][32][33][34] Articles in question of inclusion and exclusion criteria were discussed among the authors to reach a consensus decision.…”

Section: Methodsmentioning

confidence: 99%

Long-Term Outcomes after Autologous Chondrocyte Implantation

et al. 2016

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Long-Term Outcomes after Autologous Chondrocyte Implantation

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Second, severe surgical trauma caused by too many defects (4 defects) in both legs might have negatively influenced osteochondral regeneration and articular function recovery3738. Third, appropriate postoperative care and rehabilitation, which is difficult to guarantee in a large animal model, might impose another important negative factor394041. Finally, individual differences among animals might also influence ultimate repair outcomes.…”

Section: Discussionmentioning

confidence: 99%

Repair of osteochondral defects with in vitro engineered cartilage based on autologous bone marrow stromal cells in a swine model

Liu

Luo

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Functional reconstruction of large osteochondral defects is always a major challenge in articular surgery. Some studies have reported the feasibility of repairing articular osteochondral defects using bone marrow stromal cells (BMSCs) and biodegradable scaffolds. However, no significant breakthroughs have been achieved in clinical translation due to the instability of in vivo cartilage regeneration based on direct cell-scaffold construct implantation. To overcome the disadvantages of direct cell-scaffold construct implantation, the current study proposed an in vitro cartilage regeneration strategy, providing relatively mature cartilage-like tissue with superior mechanical properties. Our strategy involved in vitro cartilage engineering, repair of osteochondral defects, and evaluation of in vivo repair efficacy. The results demonstrated that BMSC engineered cartilage in vitro (BEC-vitro) presented a time-depended maturation process. The implantation of BEC-vitro alone could successfully realize tissue-specific repair of osteochondral defects with both cartilage and subchondral bone. Furthermore, the maturity level of BEC-vitro had significant influence on the repaired results. These results indicated that in vitro cartilage regeneration using BMSCs is a promising strategy for functional reconstruction of osteochondral defect, thus promoting the clinical translation of cartilage regeneration techniques incorporating BMSCs.

show abstract

“…Hence, the differentiation of stem cells before transplantation is a strategy to lock the mesenchymal stem cells into the desired differentiation state, that is, chondrocytes (Dickhut et al, 2009). Earlier in vitro studies have revealed that transforming growth factor beta (TGF-b), Ascorbate 2 phosphate (A-2P), and dexamethasone containing media support the synthesis of proteoglycans (Johnstone et al, 2006;Chubinskaya et al, 2011;Viste et al, 2012;Ude et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Adipose stem cells differentiated chondrocytes regenerate damaged cartilage in rat model of osteoarthritis

Latief

Raza

Bhatti

et al. 2016

Cell Biology International

View full text Add to dashboard Cite

Transplantation of mesenchymal stem cells (MSCs) or autologous chondrocytes has been shown to repair damages to articular cartilage due to osteoarthritis (OA). However, survival of transplanted cells is considerably reduced in the osteoarthritic environment and it affects successful outcome of the transplantation of the cells. Differentiated chrondroytes derived from adipose stem cells have been proposed as an alternative source and our study investigated this possibility in rats. We investigated the regenerative potential of ADSCs and DCs in osteoarthritic environment in the repair of cartilage in rats. We found that ADSCs maintained fibroblast morphology in vitro and also expressed CD90 and CD29. Furthermore, ADSCs differentiated into chondrocytes, accompanied by increased level of proteoglycans and expression of chondrocytes specific genes, such as, Acan, and Col2a1. Histological examination of transplanted knee joints showed regeneration of cartilage tissue compared to control OA knee joints. Increase in gene expression for Acan, Col2a1 with concomitant decrease in the expression of Col1a1 suggested formation of hyaline like cartilage. A significant increase in differentiation index was observed in DCs and ADSCs transplanted knee joints (P = 0.0110 vs. P = 0.0429) when compared to that in OA control knee joints. Furthermore, transplanted DCs showed increased proliferation along with reduction in apoptosis as compared to untreated control. In conclusion, DCs showed better survival and regeneration potential as compared with ADSCs in rat model of OA and thus may serve a better option for regeneration of osteoarthritic cartilage.

show abstract

Autologous chondrocyte implantation for traumatic full-thickness cartilage defects of the knee in 14 patients: 6-year functional outcomes

Abstract: IV, prospective therapeutic study.

Cited by 32 publications

References 28 publications

Long-Term Outcomes after Autologous Chondrocyte Implantation

Long-Term Outcomes after Autologous Chondrocyte Implantation

Repair of osteochondral defects with in vitro engineered cartilage based on autologous bone marrow stromal cells in a swine model

Adipose stem cells differentiated chondrocytes regenerate damaged cartilage in rat model of osteoarthritis

Contact Info

Product

Resources

About