Autologous Chondrocyte Implantation and Osteochondral Cylinder Transplantation in Cartilage Repair of the Knee Joint

Horas, U.; Pelinkovic, Dalip; Herr, G.; Aigner, Thomas; Schnettler, Reinhard

doi:10.2106/00004623-200302000-00001

Cited by 761 publications

(616 citation statements)

References 30 publications

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“…Transplantation of osteochondral cylinders (autograft, allograft) have been used with reported success [8,21,22]. Using the OATS technique, Laprell and Petersen [21] found a normal function in 12 of 35 patients, a nearly normal function in 14 of 35 and an abnormal function in 3 of 35 after a mean follow-up of 8.1 years.…”

Section: Discussionmentioning

confidence: 99%

Treatment of osteochondritis dissecans of the femoral condyle with autologous bone grafts and matrix-supported autologous chondrocytes

Steinhagen

Bruns

Deuretzbacher

et al. 2009

International Orthopaedics (SICOT)

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The objective of this study was to determine the clinical outcome of combined bone grafting and matrixsupported autologous chondrocyte transplantation in patients with osteochondritis dissecans of the knee. Between January 2003 and March 2005, 21 patients (mean age 29.33 years) with symptomatic osteochondritis dissecans (OCD) of the medial or lateral condyle (grade III or IV) of the knee underwent reconstruction of the joint surface by autologous bone grafts and matrix-supported autologous chondrocyte transplantation. Patients were followed up at three, six, 12 and 36 months to determine outcomes by clinical evaluation based on Lysholm score, IKDC and ICRS score. Clinical results showed a significant improvement of Lysholm-score and IKDC score. With respect to clinical assessment, 18 of 21 patients showed good or excellent results 36 months postoperatively. Our study suggests that treatment of OCD with autologous bone grafts and matrix-supported autologous chondrocytes is a possible alternative to osteochondral cylinder transfer or conventional ACT.

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Section: Discussionmentioning

confidence: 99%

Treatment of osteochondritis dissecans of the femoral condyle with autologous bone grafts and matrix-supported autologous chondrocytes

Steinhagen

Bruns

Deuretzbacher

et al. 2009

International Orthopaedics (SICOT)

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“…However, this technique possesses many inherent limitations including donor site morbidity, limited quantity of suitable host tissue as well as the difficulty in correctly matching the topography of the graft with the healthy tissue surrounding the defect site [5]. Issues including incomplete integration between the host tissue and graft tissue [6] and the degradation of the graft tissue are often observed [7]. Tissue Engineering (TE) strategies may provide significant advantages compared to these more traditional clinical treatment methods.…”

Section: Introductionmentioning

confidence: 99%

A biomimetic multi-layered collagen-based scaffold for osteochondral repair

et al. 2014

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“…9 Inadequate bonding of the graft cartilage to surrounding tissue is a common finding noted in second-look arthroscopy in clinical subjects 10 as well as histological analysis in animal models. 11,12 Synthetic tissue-engineered multiphasic implants consisting of distinct cartilage and bone layers are an area of increasing research interest. This treatment method has the potential to restore the anatomical osteochondral junction without iatrogenic injury at donor sites and with the flexibility to treat larger lesions.…”

mentioning

confidence: 99%

A novel MSC‐seeded triphasic construct for the repair of osteochondral defects

Marquaß

Somerson

Hepp

et al. 2010

Journal Orthopaedic Research

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Mesenchymal stem cells (MSC) are increasingly replacing chondrocytes in tissue engineering based research for treatment of osteochondral defects. The aim of this work was to determine whether repair of critical-size chronic osteochondral defects in an ovine model using MSC-seeded triphasic constructs would show results comparable to osteochondral autografting (OATS). Triphasic implants were engineered using a beta-tricalcium phosphate osseous phase, an intermediate activated plasma phase, and a collagen I hydrogel chondral phase. Autologous MSCs were used to seed the implants, with chondrogenic predifferentiation of the cells used in the cartilage phase. Osteochondral defects of 4.0 mm diameter were created bilaterally in ovine knees (n = 10). Six weeks later, half of the lesions were treated with OATS and half with triphasic constructs. The knees were dissected at 6 or 12 months. With the chosen study design we were not able to demonstrate significant differences between the histological scores of both groups. Subcategory analysis of O'Driscoll scores showed superior cartilage bonding in the 6-month triphasic group compared to the autograft group. The 12-month autograft group showed superior cartilage matrix morphology compared to the 12-month triphasic group. Macroscopic and biomechanical analysis showed no significant differences at 12 months. Autologous MSC-seeded triphasic implants showed comparable repair quality to osteochondral autografts in terms of histology and biomechanical testing.

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Autologous Chondrocyte Implantation and Osteochondral Cylinder Transplantation in Cartilage Repair of the Knee Joint

Cited by 761 publications

References 30 publications

Treatment of osteochondritis dissecans of the femoral condyle with autologous bone grafts and matrix-supported autologous chondrocytes

Treatment of osteochondritis dissecans of the femoral condyle with autologous bone grafts and matrix-supported autologous chondrocytes

A biomimetic multi-layered collagen-based scaffold for osteochondral repair

A novel MSC‐seeded triphasic construct for the repair of osteochondral defects

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