Autologous Chondrocyte Implantation

Jones, Deryk G.; Peterson, Lars

doi:10.1007/978-1-59745-343-1_10

Cited by 25 publications

(31 citation statements)

References 58 publications

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“…In recent years, a range of methods have been developed for the repair of articular cartilage lesions. These include osteochondral transplantation, microfracture and ACT performed by the use of suitable scaffolds, which provide a biodegradable three‐dimensional structure for tissue development facilitating at the meantime the surgical procedure and the expression of specific molecules by the cells 20, 21. Several biomaterials have been used in cartilage tissue engineering, one of the most suitable based on hyaluronic acid which is a naturally occurring and highly conserved glycosaminoglycan, widely distributed in body.…”

Section: Discussionmentioning

confidence: 99%

“…Many articles refer to the use of chondrocytes transplantation in the regeneration of cartilage lesions due to traumatic events by the use of autologous cells isolated from the tissue harvested in a healthy zone of the joint 20, 21, 23. The good clinical results together with the formation of a new hyaline tissue has suggested its wider application.…”

Section: Discussionmentioning

confidence: 99%

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Chondrocytes from patients with osteoarthritis express typical extracellular matrix molecules once grown onto a three‐dimensional hyaluronan‐based scaffold

Cavallo

Desando

Facchini

et al. 2009

J Biomedical Materials Res

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The opportunity to apply autologous chondrocyte transplantation in repairing cartilage lesions in osteoarthritis (OA) is of great interest. To this end, chondrocytes from cartilage of these patients and from healthy donors were used to evaluate the expression of some extracellular matrix molecules once these cells were grown onto a hyaluronan-based scaffold already used in clinical practice. Constructs were analyzed by immunohistochemical and real-time PCR analyses. Chondrocytes from control and patients with OA cartilages expressed the same extracellular matrix molecules even if at different amount. These differences, which were appreciable both at protein and molecular levels, were not evident once the cells were grown onto Hyaff-11 scaffold. In this experimental culture condition, the cells derived from control and patients with OA showed a significant increase of collagen type II, Sox-9, and aggrecan and a decrease of collagen type I compared with chondrocytes grown in monolayer. On the other hand, MMPs were downregulated in both the cell types evaluated by the specific action of TIMP-1 which was highly expressed at molecular and protein levels in the two groups. The growth of chondrocytes onto Hyaff-11 membrane seems to erase the differences between the cells derived from normal and OA cartilages. The cells seem to benefit of the "hyaluronan" presence which is able to create an ideal environment for the expression of cartilage genes even in absence of specific growth factors. This is of particular relevance hypothesizing the use of tissue engineering therapeutical approach also in patients with OA.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Chondrocytes from patients with osteoarthritis express typical extracellular matrix molecules once grown onto a three‐dimensional hyaluronan‐based scaffold

Cavallo

Desando

Facchini

et al. 2009

J Biomedical Materials Res

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“…5 There have been continuous efforts to improve the treatment outcomes for medium-and large-sized defects. 6,7 Recently, many clinical studies have been published regarding platelet-rich plasma (PRP) injection for early degenerative joint disease. [8][9][10] As PRP is a natural concentrate of autologous growth factors from the blood, it can be assumed that it accelerates tissue healing.…”

Section: Introductionmentioning

confidence: 99%

The effect of platelet rich plasma combined with microfracture for the treatment of chondral defect in a rabbit knee

Huh

Shetty

Kim

et al. 2014

Tissue Eng Regen Med

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Recently, many clinical studies have been published regarding platelet-rich plasma (PRP) injection for early degenerative joint disease. We evaluated the cartilage repair potential of platelet-rich plasma when injected into the knee joint. Articular, cartilage defects 4 mm in diameter and circular in shape were made in the trochlear region of 20 knees in 10 New Zealand white rabbits who were divided into two groups. The left knees in the control group underwent microfracture, and the right knees in the experimental group underwent microfracture with subsequent injection of platelet-rich plasma. At week 12 following the surgery, the cartilage was observed macroscopically and histologically compared in the two groups. The control group showed incomplete and irregular fibrous tissue formation in the defect. The experimental group showed nearly complete defect coverage with neo-cartilage. In the histologic scoring, comparison of the control group and the experimental group differed significantly (p < 0.05).Therefore, injection of platelet-rich plasma used to treat articular cartilage defects of the knee appears to have some effect for cartilage regeneration.

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“…Current therapies aimed at improving these symptoms include subchondral drilling, microfractures, osteochondral transplantation, autologous chondrocyte implantation (ACI), and replacement of the diseased joint with a prosthesis. However, these therapies suffer from serious drawbacks, such as donor site and joint morbidity, the presence of alloplastic material, suboptimal long‐term outcome and even structural failure .…”

Section: Introductionmentioning

confidence: 99%

The cell‐engineered construct of cartilage on the basis of biopolymer hydrogel matrix and human adipose tissue‐derived mesenchymal stromal cells (in vitro study)

Surguchenko

Пономарева

Кирсанова

et al. 2014

J Biomedical Materials Res

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The study results of in vitro formation of tissue-engineered cartilage construct on the basis of cell-engineered construct composed of biopolymer hydrogel matrix and human adipose tissue-derived mesenchymal stromal cells (hADSCs) are presented. It was revealed that hADSCs in biopolymer hydrogel matrix Sphero®GEL under chondrogenic conditions generate three-dimensional structures and produce cartilaginous extracellular matrix components: collagen type II and glycosaminoglycans.

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Autologous Chondrocyte Implantation

Cited by 25 publications

References 58 publications

Chondrocytes from patients with osteoarthritis express typical extracellular matrix molecules once grown onto a three‐dimensional hyaluronan‐based scaffold

Chondrocytes from patients with osteoarthritis express typical extracellular matrix molecules once grown onto a three‐dimensional hyaluronan‐based scaffold

The effect of platelet rich plasma combined with microfracture for the treatment of chondral defect in a rabbit knee

The cell‐engineered construct of cartilage on the basis of biopolymer hydrogel matrix and human adipose tissue‐derived mesenchymal stromal cells (in vitro study)

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