Autologous Chondrocyte Implantation

Peterson, Lars; Vasiliadis, Haris S.; Brittberg, Mats; Lindahl, Anders

doi:10.1177/0363546509357915

Cited by 646 publications

(588 citation statements)

References 33 publications

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“…Our results agree with other published studies which have shown that ACI tissue needs time to remodel and continues to improve in quality with time 3 . However, even after 20 months the ACI repair tissue has fewer GAGs with different sulphation patterns than controls.…”

Section: Discussionsupporting

confidence: 93%

“…Previous studies of patient knee function scores following ACI have indicated the importance of a two-year post-operative status as an indicator of the long term success of this treatment 2,3,9,10 . Whilst these results are reassuring there remains concern about the quality of the cartilage formed within the defect.…”

Section: Discussionmentioning

confidence: 99%

“…To date, ACI has been used to treat cartilage defects in thousands of patients worldwide with good clinical effectiveness several years after implantation 2,3 .…”

Section: Introductionmentioning

confidence: 99%

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A case study: Glycosaminoglycan profiles of autologous chondrocyte implantation (ACI) tissue improve as the tissue matures

et al. 2017

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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A case study: Glycosaminoglycan profiles of autologous chondrocyte implantation (ACI) tissue improve as the tissue matures

et al. 2017

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“…Autologous chondrocyte implantation (ACI) is a cell-based cartilage repair technology using ex vivo cultivated chondrocytes. It has been established for the treatment of full cartilage defects of the knee joint in clinical routine with proven long-term efficacy [6]. For some years matrix associated ACI (MACI) has emerged abandoning the periosteal flap and thereby providing easier and time-saving handling [7].…”

Section: Introductionmentioning

confidence: 99%

Treatment of deep articular talus lesions by matrix associated autologous chondrocyte implantation—results at five years

Anders

Goetz

Schubert

et al. 2012

International Orthopaedics (SICOT)

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Purpose Treatment of focal full-thickness chondral or osteochondral defects of the talus remains a challenge. The aim of this study was to evaluate the postoperative success and the long-term efficacy of matrix associated autologous chondrocyte implantation in these defects. Methods Matrix associated autologous chondrocyte implantation (MACI) was applied in 22 consecutive patients (mean age 23.9 years) with full-thickness chondral or osteochondral lesions of the talus. The average defect-size was 1.94 cm² (range 1-6). In case of osteochondritis dissecans (n013) an autologous bone graft was performed simultaneously. Follow-ups were routinely scheduled up to 63.5 (±7.4) months, consisting of clinical evaluation and magnetic resonance imaging. Results The AOFAS score improved significantly from 70.1 to 87.9/92.6/93.5/95.0/95.5 and 95.3 points at three, six, 12, 24, 36 and 63.5 months, respectively. On a visual analogue scale, pain intensity decreased from 5.7 (±2.6) to 0.9 (±0.8) while subjective function increased from 5.3 (±2.3) to 8.9 (±0.9) at final follow-up (each p<0.001). The Tegner score rose significantly from 2.4 (±1.2) to 4.7 (±0.6). The MOCART score improved from 62.6 (±19.4) at three months to 83.8 (±9.4) at final follow-up. No significant differences were found between lesions caused by osteochondritis dissecans or trauma and between first-or second-line treatments. For all scores, the most benefit was seen within the first 12 months with stable results afterwards. No major complications were noted. Conclusions Matrix associated autologous chondrocyte implantation is capable of significant and stable long-term improvement of pain and functional impairment caused by focal full-thickness chondral and osteochondral talus lesions.

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“…The cell suspension is retained by either a patch of periosteum or a commercially available collagen membrane, sutured to the edges of the defect and sealed with fibrin. Our center has used ACI in approximately 500 procedures and we and others have shown that it has the potential to improve functional outcome [2][3][4] and generate repair tissue that offers a durable surface and is well integrated with the surrounding cartilage [5][6][7][8]. In our audits of ACI, 80% of patients improve by 15 months, and this improvement is sustained for 9-16 years [3,9].…”

mentioning

confidence: 98%

Efficacy and Safety of Autologous Cell Therapies for Knee Cartilage Defects (Autologous Stem Cells, Chondrocytes or the Two): Randomized Controlled Trial Design

et al. 2017

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Aim: The main aim of this trial is to test the safety and efficacy of autologous stromal/stem cells, chondrocytes or the two combined in the treatment of knee cartilage defects. Patients & methods: Patients with symptomatic chondral/osteochondral defects will be randomized to cell therapy treatment with one of three cell populations (1:1:1). The primary efficacy outcome is a functional knee score (Lysholm) at 15 months post-treatment and the primary safety outcome is the incidence of adverse events. Secondary objectives are to analyze repair tissues, quality of life and cost-utility assessments. Exploratory objectives are to identify predictors for success/potency and dose–response relationships. Results & conclusion: This trial has been carefully designed so that valuable scientific and clinical information can be gathered throughout and in the final analysis.

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Autologous Chondrocyte Implantation

Cited by 646 publications

References 33 publications

A case study: Glycosaminoglycan profiles of autologous chondrocyte implantation (ACI) tissue improve as the tissue matures

A case study: Glycosaminoglycan profiles of autologous chondrocyte implantation (ACI) tissue improve as the tissue matures

Treatment of deep articular talus lesions by matrix associated autologous chondrocyte implantation—results at five years

Efficacy and Safety of Autologous Cell Therapies for Knee Cartilage Defects (Autologous Stem Cells, Chondrocytes or the Two): Randomized Controlled Trial Design

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