Autologous Bone Marrow Transplantation in Osteonecrosis of the Femoral Head

Hwang, Jihyo; Lee, Soo-ho; Kim, Mi‐Jung

doi:10.4172/2157-7552.1000103

Cited by 7 publications

(7 citation statements)

References 32 publications

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“…The average number of TNCCs obtained after processing bone marrow was 137x103/ µL, with 4.9% monocytes and 13.8% lymphocytes on an average. The patients did not experience any side effects and results from a two year follow up period showed that the disease did not progress to later stages [10]. Similarly, in a prospective study by Hernigouet al (2002) on 116 patients with a vascular necrosis of the femoral head, same cell separation technology was used and it was observed that the mean cell dose administered was 16.4 million cells and the average total number of colony-forming units injected was estimated to be 25x10 3 cells.…”

Section: Discussionmentioning

confidence: 89%

valuation of Safety and Preliminary Effectiveness of Point-of-Care Cell Processing System: An Observational Study

Gupta¹,

Suthar²,

Sethi³

et al. 2018

Stem Cells Regen Med

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The potential of cell therapy in treating incurable and irreversible diseases has been proven to be safe and feasible with varying degrees of success in medical fraternity. In the past decade, there has been a steady increase in the development of advanced point-of-care cell processing technologies and intra-operative procedures that integrate autologous cell-based therapy with conventional surgical procedure in a single sitting, have emerged as an exciting approach in regenerative medicine and cell therapy field. Point-of-care (POC) cell processing devices are automatic, closed systems that allow rapid processing of whole tissue to the desired cell population at the patient's bedside, at an affordable cost. This observational study evaluates the safety and feasibility of a rapid point-of-care technology, the Res-Q™ 60 system used for processing bone marrow and/or peripheral blood intraoperatively for treating patients with various clinical indications who were administered the cell therapy product either as a standalone treatment or in conjunction with standard-of-care treatment. The data from 254 patients treated using either Bone Marrow Concentrate (BMC) or Platelet Rich Plasma (PRP) produced by Res-Q™ 60 devices was observed and analysed for device performance including cellularity, sterility and safety. The cellular output from Res-Q™ 60 BMC and PRP devices showed a significantly high MNC recovery of 71.35% ± 2.10 (SD) and platelet recovery of 78.3% ± 3.0 (SD), respectively. All the samples were sterile with no bacterial or fungal growth and all the patients tolerated the device output i.e. BMC or PRP well with no related adverse events (SAEs/ AEs). Therefore, the Res-Q™ 60 BMC and PRP devices were found to be safe, feasible and preliminary effective for autologous cellular therapy at the point-of-care.

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Section: Discussionmentioning

confidence: 89%

valuation of Safety and Preliminary Effectiveness of Point-of-Care Cell Processing System: An Observational Study

Gupta¹,

Suthar²,

Sethi³

et al. 2018

Stem Cells Regen Med

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“…A bone marrow transplant [65] is a procedure to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Bone marrow is the soft, fatty tissue inside your bones.…”

Section: Tissue Transplantation-bone Marrow Transplantmentioning

confidence: 99%

Assessment & Effectiveness of Surgeries in Human Safety

D¹

2012

J Clin Exp Ophthalmol

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Emergency surgery: A surgical procedure that cannot be delayed, for which there is no alternative therapy or surgeon, and for which a delay could result in death or permanent impairment of health. Exploratory surgery: it is a diagnostic method used by doctors when trying to find a diagnosis for an ailment. It can be performed in both humans and animals, but it is far more common in animals. It is used most commonly to diagnose or locate cancer [10] in humans, but it can be used for other ailments as well. Amputation: Removal of part or all of a body part enclosed by skin. Amputation usually takes place during surgery [11] in a hospital operating room. It is performed to prevent the spread of gangrene as a complication of frostbite, injury, diabetes [12], arteriosclerosis (hardening of the arteries), or any other illness that impairs blood circulation. It is also performed to prevent the spread of bone cancer

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“…While it is outside the scope of this work to review all of the exciting developments in the field, a series of recent clinical studies (2011 to the present) have been chosen arbitrarily to highlight how the previously discussed elements of tissue engineering have been applied to treat orthopaedic diseases [53][54][55][56][57][58][59][60][61][62][63] . Examples were chosen from the following areas: fracture nonunion, osteonecrosis, and chondral and osteochondral defects.…”

Section: Orthopaedic Tissue Engineering Elements Applied In Recent CLmentioning

confidence: 99%