Autologous Bone Grafting in Trauma and Orthopaedic Surgery: An Evidence-Based Narrative Review

Migliorini, Filippo; Cuozzo, Francesco; Torsiello, Ernesto; Spiezia, Filippo; Oliva, Francesco; Maffulli, Nicola

doi:10.3390/jcm10194347

Cited by 28 publications

(17 citation statements)

References 104 publications

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“…The "point-to-surface contact" between the titanium mesh cage and the endplate results in a very high-pressure intensity on the contact surface, making it easy for a stress-shielding effect to occur [32][33] . In contrast, the n-HA/PA66 strut ends have a wider surface to form "face-to-face contact" with the endplate, which can effectively distribute the load on the contact surface, avoiding cutting effects [21] . In addition, The grooves at both ends of the n-HA/PA66 strut are designed to increase the friction between the cage and the endplates can effectively avoid the sinking and displacement of the strut.…”

Section: Discussionmentioning

confidence: 99%

Applied nano-hydroxyapatite/polyamide 66 strut in anterior reconstructive surgery for lumbar spinal tuberculosis： a comparison with autogenous iliac bone graft.

Fei

Zhang

et al. 2022

Preprint

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This study aimed to compare the clinical efficacy of nano-hydroxyapatite/polyamide 66 strut （n-HA/PA66 group） with autogenous iliac bone grafts（AIBG group） in anterior reconstructive surgery for lumbar spinal tuberculosis（LSTB）. A total of 67 patients with LSTB who underwent one-stage combined anterior-posterior surgery using an n-HA/PA66 strut or an autogenous iliac bone graft were studied retrospectively at a mean follow-up of 33.8±7.0 months. The Data about erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Orthopaedic Association (JOA) and Oswestry Disability Index (ODI)score, visual analog scale (VAS) score, American Spinal Injury Association（ASIA ）grade, and Cobb's angle were recorded and compared between the two groups before surgery, three months after surgery and at the last follow-up. At the last follow-up, both groups achieved satisfactory bony fusion without recurrence of tuberculosis, while ESR, CRP, VAS, ASIA grade, and Cobb angle were significantly improved at the last follow-up compared to the preoperative. The n-HA/PA66 group was superior in operation time(P < 0.05), intraoperative blood loss (P < 0.05), VAS at 3 months after surgery (P < 0.05), and surgical complications as compared with the AIBG group. But the bone fusion time of the n-HA/PA66 group (8.4±1.3 months) was slightly longer than the TMC group (7.5±1.6 months)( P < 0.05). The nano-hydroxyapatite/polyamide 66 strut can achieve good clinical efficacy comparable to autologous iliac bone grafts when treating tuberculosis of the lumbar spine. The less traumatic， lower incidence of complications， and similar excellent bony fusion indicated it could serve as a superior material in the anterior reconstructive surgery for lumbar spinal tuberculosis.

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Section: Discussionmentioning

confidence: 99%

Applied nano-hydroxyapatite/polyamide 66 strut in anterior reconstructive surgery for lumbar spinal tuberculosis： a comparison with autogenous iliac bone graft.

Fei

Zhang

et al. 2022

Preprint

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“…This type of graft cannot induce adverse immune reactions because it is autologous, has osteogenic, osteoinductive, and osteoconductive capabilities and stimulates osteoproliferation with rapid healing. However, the need for an additional invasive operation, increased morbidity, pain, and the difficulty of the harvesting areas, reduce the rates of use of autologous bone grafting [ 6 ]. Furthermore, growth factors are released only after the graft has been completely resorbed [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Autologous Tooth Graft: Innovative Biomaterial for Bone Regeneration. Tooth Transformer® and the Role of Microbiota in Regenerative Dentistry. A Systematic Review

Inchingolo

Patano

Pede

et al. 2023

JFB

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Different biomaterials, from synthetic products to autologous or heterologous grafts, have been suggested for the preservation and regeneration of bone. The aim of this study is to evaluate the effectiveness of autologous tooth as a grafting material and examine the properties of this material and its interactions with bone metabolism. PubMed, Scopus, Cochrane Library, and Web of Science were searched to find articles addressing our topic published from 1 January 2012 up to 22 November 2022, and a total of 1516 studies were identified. Eighteen papers in all were considered in this review for qualitative analysis. Demineralized dentin can be used as a graft material, since it shows high cell compatibility and promotes rapid bone regeneration by striking an ideal balance between bone resorption and production; it also has several benefits, such as quick recovery times, high-quality newly formed bone, low costs, no risk of disease transmission, the ability to be performed as an outpatient procedure, and no donor-related postoperative complications. Demineralization is a crucial step in the tooth treatment process, which includes cleaning, grinding, and demineralization. Since the presence of hydroxyapatite crystals prevents the release of growth factors, demineralization is essential for effective regenerative surgery. Even though the relationship between the bone system and dysbiosis has not yet been fully explored, this study highlights an association between bone and gut microbes. The creation of additional scientific studies to build upon and enhance the findings of this study should be a future objective of scientific research.

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“…Knowledge of the mechanical properties of cancellous bone is beneficial not only for understanding degenerative bone diseases such as osteoporosis and osteoarthritis [ 1 – 3 ], but also for the development of bone grafting techniques and substitute materials, as well as their clinical application in trauma and orthopaedic surgery [ 3 – 5 ].…”

Section: Introductionmentioning

confidence: 99%

Selected mechanical properties of human cancellous bone subjected to different treatments: short-term immersion in physiological saline and acetone treatment with subsequent immersion in physiological saline

et al. 2022

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Background Physiological saline (0.9% NaCl) and acetone are extensively used for storage (as well as hydration) and removal of bone marrow, respectively, of cancellous bone during preparation and mechanical testing. Our study aimed to investigate the mechanical properties of cancellous bone subjected to short-term immersion in saline and acetone treatment with subsequent immersion in saline. Methods Cylindrical samples (Ø6 × 12 mm) were harvested from three positions (left, middle, and right) of 1 thoracic vertebral body, 19 lumbar vertebral bodies, and 5 sacral bones, as well as from 9 femoral heads. All samples were divided into two groups according to the different treatments, (i) samples from the left and middle sides were immersed in saline at 4℃ for 43 h (saline-immersed group, n = 48); (ii) samples from the respective right side were treated with a combination of acetone and ultrasonic bath (4 h), air-dried at room temperature (21℃, 15 h), and then immersed in saline at room temperature (21℃, 24 h) (acetone and saline-treated group, n = 38). All samples were subjected, both before and after treatment, to a non-destructive compression test with a strain of 0.45%, and finally destructive tests with a strain of 50%. Actual density (ρact), initial modulus (E0), maximum stress (σmax), energy absorption (W), and plateau stress (σp) were calculated as evaluation indicators. Results Based on visual observation, a combination of acetone and ultrasonic bath for 4 h failed to completely remove bone marrow from cancellous bone samples. The mean values of ρact, σmax, W, and σp were significantly higher in the femoral head than in the spine. There was no significant difference in E0 between non-treated and saline-immersed samples (non-treated 63.98 ± 20.23 vs. saline-immersed 66.29 ± 20.61, p = 0.132). The average E0 of acetone and saline-treated samples was significantly higher than that of non-treated ones (non-treated 62.17 ± 21.08 vs. acetone and saline-treated 74.97 ± 23.98, p = 0.043). Conclusion Short-term storage in physiological saline is an appropriate choice and has no effect on the E0 of cancellous bone. Treatment of cancellous bone with acetone resulted in changes in mechanical properties that could not be reversed by subsequent immersion in physiological saline.

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Autologous Bone Grafting in Trauma and Orthopaedic Surgery: An Evidence-Based Narrative Review

Cited by 28 publications

References 104 publications

Applied nano-hydroxyapatite/polyamide 66 strut in anterior reconstructive surgery for lumbar spinal tuberculosis： a comparison with autogenous iliac bone graft.

Applied nano-hydroxyapatite/polyamide 66 strut in anterior reconstructive surgery for lumbar spinal tuberculosis： a comparison with autogenous iliac bone graft.

Autologous Tooth Graft: Innovative Biomaterial for Bone Regeneration. Tooth Transformer® and the Role of Microbiota in Regenerative Dentistry. A Systematic Review

Selected mechanical properties of human cancellous bone subjected to different treatments: short-term immersion in physiological saline and acetone treatment with subsequent immersion in physiological saline

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