Autologous blood transfusion: Preoperative blood collection and blood salvage techniques

Bengtsson, Anders; Bengtson, J. P.

doi:10.1111/j.1399-6576.1996.tb05622.x

Cited by 28 publications

(17 citation statements)

References 100 publications

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“…After infusion of filtered salvaged blood, hypotension, hyperthermia and febrile reactions have been reported. 4,9,10 Febrile non-hemolytic reactions occur in patients receiving platelet transfusions. 4 In the present study there were no signs of adverse reactions that could be explained by salvaged blood infusion.…”

Section: Discussionmentioning

confidence: 99%

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Complement split products and pro-inflammatory cytokines in salvaged blood after hip and knee arthroplasty

Andersson

Tylman

Bengtson

et al. 2001

Can J Anesth/J Can Anesth

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Purpose: To determine whether salvaged autologous blood collected postoperatively contains complement split products (SC5b-9), and pro-inflammatory cytokines (IL-6 and IL-8) and whether there are any differences between blood collected during hip or knee surgery.Methods: Fifty-eight consecutive patients undergoing hip or knee replacement surgery were studied. Thirty-eight had postoperative bleeding large enough to require infusion of salvaged blood. The salvaged blood was filtered during collection through a 200 µm filter and before infusion a 40 µm filter was used. Samples for complement and cytokine determinations were drawn from the circulation and from the collected blood.Results: High concentrations of SC5b-9, IL-6, and IL-8 were found in salvaged blood. The concentrations were higher than in the circulation (P < 0.05). The circulating concentrations of IL-6 and IL-8 were increased 60 min and 12-18 hr after transfusion. There were no differences regarding SC5b-9, IL-6, and IL-8 in the blood collected after hip or knee surgery.Conclusion: Blood collected from a surgical wound contains large concentrations of inflammatory mediators. There were no differences between blood collected during hip or knee surgery.Objectif : Déterminer si la récupération postopératoire de sang autologue contient des produits de dégradation du complément (SC5b-9) et des cytokines pro-inflammatoires (IL-6 et IL-8), et s'il y a des différences avec le sang prélevé pendant l'opération de la hanche ou du genou.Méthode : L'étude a porté sur 58 patients successivement admis pour la mise en place d'une prothèse de hanche ou du genou. Chez 38 d'entre eux, les pertes sanguines postopératoires ont été assez importantes pour néces-siter la transfusion de sang récupéré. Ce sang a été filtré pendant le prélèvement avec un filtre de 200 µm et avant la transfusion avec un filtre de 40 µm. Des échantillons retenus de la circulation et du sang récupéré ont servi à déterminer la cytokine et le complément.

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Section: Discussionmentioning

confidence: 99%

“…Autotransfusion can be subdivided depending on the extent to which the scavenged blood is processed prior to infusion. 4 In filter systems the salvaged blood is anti-coagulated and filtered, whereas in other autotransfusion systems the salvaged blood is washed and centrifuged prior to infusion.…”

mentioning

confidence: 99%

Complement split products and pro-inflammatory cytokines in salvaged blood after hip and knee arthroplasty

Andersson

Tylman

Bengtson

et al. 2001

Can J Anesth/J Can Anesth

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“…Erythropoietin used alone or in conjunction with preoperative autologous donation programs has been shown to increase preoperative donation, maintain perioperative hemoglobin levels, and reduce the need for allogenic transfusion. 10 Other agents such as aminocaproic acid (Amicar) attenuate or inhibit fibrinolysis and have demonstrated benefit in reducing operative losses. 5 These pharmacologic agents are expensive and currently not routinely employed in aneurysm surgery at our institution.…”

Section: Discussionmentioning

confidence: 99%

Impact of Red Cell Salvage on Transfusion Requirements During Elective Abdominal Aortic Aneurysm Repair

Szalay

Wong

Lindsay

1999

Annals of Vascular Surgery

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“…It is known that surgical trauma activates neutrophils and increases the local production of IL‐6 and C 3a in patients undergoing TKR 39 and that concentrations of proinflammatory IL‐6 and IL‐8 and of complement split products (C 5b‐9 ) in shed unwashed blood are higher than in control blood 34 . Concerns have been raised that return of these compounds may induce hypotension, hyperthermia, and febrile reactions 40‐42 …”

Section: Discussionmentioning

confidence: 99%

Composition of the blood sampled from surgical drainage after joint arthroplasty: quality of return

Sinardi¹,

Marino²,

Chillemi³

et al. 2005

Transfusion

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Autologous blood transfusion: Preoperative blood collection and blood salvage techniques

Cited by 28 publications

References 100 publications

Complement split products and pro-inflammatory cytokines in salvaged blood after hip and knee arthroplasty

Complement split products and pro-inflammatory cytokines in salvaged blood after hip and knee arthroplasty

Impact of Red Cell Salvage on Transfusion Requirements During Elective Abdominal Aortic Aneurysm Repair

Composition of the blood sampled from surgical drainage after joint arthroplasty: quality of return

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