Autologous blood transfusion in hip replacement: No effect on blood loss but less increase of plasminogen activator inhibitor in a randomized series of 80 patients

Hedström, Margareta; Flordal, Per Anders; Ahl, Torbjörn; Svensson, Jan; Dalén, Nils

doi:10.3109/17453679609002322

Cited by 14 publications

(11 citation statements)

References 9 publications

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“…Transfusion also is associated with increased exposure to another procoagulant protein, plasminogen activator inhibitor (PAI)-1. There is a 3-to 6-fold increase in PAI-1 content of packed RBCs stored for greater than 35 days (43), and serum levels of PAI-1 increase after allogeneic blood transfusion (44). Adenosine diphosphate, a well-recognized mediator of platelet activation, might also participate in transfusion-related vascular thrombosis.…”

Section: Mechanisms Linking Blood Transfusion With Excess Mortalitymentioning

confidence: 98%

Bleeding, Blood Transfusion, and Increased Mortality After Percutaneous Coronary Intervention

Doyle

Rihal

Gastineau

et al. 2009

Journal of the American College of Cardiology

373

227

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Advances in percutaneous coronary intervention (PCI) during the past decade have led to more widespread use of these procedures in older and sicker patients. Refinement of periprocedural antithrombotic therapy has played a particularly important role in reducing ischemic complications to very low levels in routine practice. Although the use of more powerful antiplatelet agents has been associated with increased risk of bleeding (especially among the elderly and patients with serious comorbidities), such complications have traditionally been viewed as benign in nature. Recent studies, however, have identified major bleeding after PCI as an important predictor of increased mortality. Whether this relationship between bleeding and risk of death is cause-and-effect, or merely an association based on shared risk factors, remains unclear. In this review, we examine the basis for a possible causal link between post-PCI bleeding and subsequent mortality. Possible mechanisms underpinning such a link are discussed, including a potential adverse role for blood transfusion in this setting. A framework for further clinical evaluation of this issue is presented.

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Section: Mechanisms Linking Blood Transfusion With Excess Mortalitymentioning

confidence: 98%

Bleeding, Blood Transfusion, and Increased Mortality After Percutaneous Coronary Intervention

Doyle

Rihal

Gastineau

et al. 2009

Journal of the American College of Cardiology

373

227

View full text Add to dashboard Cite

show abstract

“…Hedstrom and colleagues demonstrated an elevation of PAI-1 in vivo after allogeneic blood transfusions for postoperative anemia in orthopedic surgery patients. The rise in PAI-1 was more modest when autologous blood was used for transfusion [46].…”

Section: Prothrombotic Triggersmentioning

confidence: 99%

Proinflammatory, immunomodulating, and prothrombotic properties of anemia and red blood cell transfusions

Twomley

Rao

Becker

2006

J Thromb Thrombolysis

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For many years, the traditional treatment for hospitalized patients in the United States who have developed anemia, whether associated with medical illness, surgical procedures or trauma, has been red blood cell transfusion, despite the absence of supporting data in many patient populations. Emerging evidence suggests that transfusions may, in fact, be associated with risk beyond commonly held concerns of microbial transmission and acute antigen-antibody reactions. The following overview represents a biological paradigm for understanding the relationship between medical illness, surgical procedures, inflammatory states, anemia, red blood cell transfusion and immunothrombotic phenomena among hospitalized patients.

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“…PAI-1 also contributes to the shedding of microparticles with a high concentration of phosphatidyl-L-serine, which is a strong promoter of factor VIIa activation and thrombin production [23]. Transfusion of homologous blood produced higher circulating levels of PAI-1 in postoperative orthopedic patients than did the transfusion of autologous blood [24].…”

Section: Commentmentioning

confidence: 99%

Is Transfusion Associated With Graft Occlusion After Cardiac Operations?

Engoren

Schwann

Jewell

et al. 2015

The Annals of Thoracic Surgery

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Autologous blood transfusion in hip replacement: No effect on blood loss but less increase of plasminogen activator inhibitor in a randomized series of 80 patients

Cited by 14 publications

References 9 publications

Bleeding, Blood Transfusion, and Increased Mortality After Percutaneous Coronary Intervention

Bleeding, Blood Transfusion, and Increased Mortality After Percutaneous Coronary Intervention

Proinflammatory, immunomodulating, and prothrombotic properties of anemia and red blood cell transfusions

Is Transfusion Associated With Graft Occlusion After Cardiac Operations?

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