Autologous blood and platelet-rich plasma injection therapy for lateral elbow pain

Karjalainen, Teemu; Silagy, Michael; O'Bryan, Edward C; Johnston, Renea V; Cyril, Sheila; Buchbinder, Rachelle

doi:10.1002/14651858.cd010951.pub2

Cited by 15 publications

(12 citation statements)

References 108 publications

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“…PRP is a concentrate of plasma and platelets. It is widely used in many musculoskeletal indications, although limited evidence supports its ability to improve symptoms effectively [45][46][47]. Regarding nerves, animal models provide evidence for peripheral nerve injuries but the evidence in compression neuropathy is limited.…”

Section: How the Intervention Might Workmentioning

confidence: 99%

Update on Efficacy of Conservative Treatments for Carpal Tunnel Syndrome

Karjalanen

Raatikainen

Jaatinen

et al. 2022

JCM

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Carpal tunnel syndrome (CTS) is the most common upper extremity compression neuropathy. Non-operative interventions are usually the first-line treatments, and surgery is reserved for those that do not achieve a satisfactory symptom state by non-operative means. This narrative review summarizes the current evidence regarding the efficacy of orthoses, corticosteroid injections, platelet-rich plasma injections, Kinesio taping, neurodynamic techniques, gabapentin, therapeutic ultrasound, and extracorporeal shockwave therapy in people with CTS. While many trials suggest small short-term benefits, rigorous evidence of long-term patient-important benefits is limited. To improve the utility of healthcare resources, research in this area should focus on establishing efficacy of each treatment instead of comparing various treatments with uncertain benefits.

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Section: How the Intervention Might Workmentioning

confidence: 99%

Update on Efficacy of Conservative Treatments for Carpal Tunnel Syndrome

Karjalanen

Raatikainen

Jaatinen

et al. 2022

JCM

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“…Our recent Cochrane review found insufficient evidence to support the ongoing use of autologous blood or PRP injections in the treatment of tennis elbow. 4 Estimates from eight placebo-controlled trials sit firmly above the null effect for both pain (MD 0.16, 95% CI −0.3 to 0.6, 0–10 scale; n=523) and function (MD 1.9, 95% CI −1.3 to 5, 0–100 scale; n=502).…”

Section: Recent Evidence: Where Are We Now?mentioning

confidence: 88%

Platelet-rich plasma injection for tennis elbow: did it ever work?

Karjalainen

Richards

Buchbinder

2022

BMJ Open Sport Exerc Med

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Platelet-rich plasma (PRP) is a commonly used treatment for tendinopathies such as tennis elbow despite the questionable evidence of its efficacy. A recent Cochrane review suggests that it likely does not provide clinically meaningful benefits in people with tennis elbow. In this viewpoint, we discuss how lack of regulation allowed aggressive marketing and clinical use without normal phases of drug development and approval process or rigorous evidence of benefits. Since several phases of development were bypassed, we still do not know the optimal preparation method and dosing of PRP for tendinopathies. Furthermore, several clinical trials compared PRP with other interventions although it was unclear if PRP was better than placebo and these comparisons created distraction rather than improved understanding of its effects.

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“…Injections of autologous blood and platelet rich plasma have become increasingly popular in high resource settings in the past 20 years 29. Samples are collected from the patient and injected around the lateral epicondyle to trigger an inflammatory reaction and facilitate tendon recovery with cellular mediators.…”

Section: How Is It Managed?mentioning

confidence: 99%

“…Samples are collected from the patient and injected around the lateral epicondyle to trigger an inflammatory reaction and facilitate tendon recovery with cellular mediators. Most patients receive a single injection, although courses of two injections separated by two to four weeks have been instituted in some regimens 29…”

Section: How Is It Managed?mentioning

confidence: 99%

Management of lateral epicondylitis (tennis elbow)

Karbowiak,

Holme,

Thambyrajah

et al. 2023

BMJ

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Autologous blood and platelet-rich plasma injection therapy for lateral elbow pain

Cited by 15 publications

References 108 publications

Update on Efficacy of Conservative Treatments for Carpal Tunnel Syndrome

Update on Efficacy of Conservative Treatments for Carpal Tunnel Syndrome

Platelet-rich plasma injection for tennis elbow: did it ever work?

Management of lateral epicondylitis (tennis elbow)

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