Autologous Anti‐I and Anti‐M Following Liver Transplant

Abstract

A patient who received a liver transplant subsequently developed autologous anti‐I and anti‐M. The antibodies were demonstrated in the serum and in eluates from the patient's red blood cells, and could be separated by cross‐absorption with appropriate red blood cells. The patient received horse antilymphocyte globulin and the possibility could not be excluded that the anti‐M was transferred passively.

Naturally-Occurring Anti-M and Anti-N with Special Case: IgG Anti-N in a NN Donor

“…A final point deserves mention in relation to the frequent occurrence of anti-M : as an isologous antibody it is common, but as an autoantibody it is still a rarity. In a case reported by Tegoli et al [26], autologous anti-I and anti-M was discovered following liver transplantation. The anti-M was thought to have been passively transferred but later con firmed [17] as a true autologous antibody.…”

“…It is usually found in NN individuals, but exceptions have been found [7,26] where the antibody occurred in MN persons. Anti-N is still considered an infrequent finding, and even rarer is its occurrence in someone possessing the antigen.…”

Chronic Cold Haemagglutinin Disease Due to an Anti-M-Like Autoantibody

“…There are reports of 7 cases of auto-anti-M (6 females, 1 male), who had no evidence of antibody activity in vivo [4,6,7,9,18,19], and a further two cases (both females) associated with chronic CHAD (2,16). Of these 9 cases with autoanti-M, 3 were MM and 6 MN.…”

Auto Anti-M Antibody Following Renal Transplantation

“…Fletcher and Zmijewski [5] de scribed the first example in 1970 in a healthy pregnant woman. Since then 6 other cases have been reported [4,[8][9][10], all in females, in association with a variety of clinical situa tions including Raynaud's phenomenon, he patic transplantation and chronic aggressive hepatitis.…”