Autologous Adipose Tissue–Derived Mesenchymal Stem Cells Introduced by Biliary Stents or Local Immersion in Porcine Bile Duct Anastomoses

Zhang, Yi; Sharma, Ayushman; Joo, Dong Jin; Nelson, Erek; AbuRmilah, Anan; Amiot, Bruce; Boyer, Christen J.; Alexander, Jonathan; Jalan‐Sakrikar, Nidhi; Martin, John A.; Moreira, Roger K.; Chowdhury, Shiraj A.; Smart, Michele; Dietz, Allan B.; Nyberg, Scott L.; Heimbach, Julie K.; Huebert, Robert C.

doi:10.1002/lt.25682

Cited by 7 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two studies were published in 2020 with autologous ASCs. The first one is from Zhang et al [ 52 ]. Nine domestic white pigs were divided in three groups: G1 (control) received plastic biliary stents wrapped with Vicryl (polyglactin 910) mesh; in G2, 4 × 10 6 ASCs were added to the mesh; and G3 received non-wrapped stents and 4 × 10 6 ASCs applied topically.…”

Section: Resultsmentioning

confidence: 99%

Stem cell therapy applied for digestive anastomosis: Current state and future perspectives

Trébol¹,

Georgiev-Hristov²,

Migueláñez³

et al. 2022

WJSC

View full text Add to dashboard Cite

BACKGROUND Digestive tract resections are usually followed by an anastomosis. Anastomotic leakage, normally due to failed healing, is the most feared complication in digestive surgery because it is associated with high morbidity and mortality. Despite technical and technological advances and focused research, its rates have remained almost unchanged the last decades. In the last two decades, stem cells (SCs) have been shown to enhance healing in animal and human studies; hence, SCs have emerged since 2008 as an alternative to improve anastomoses outcomes. AIM To summarise the published knowledge of SC utilisation as a preventative tool for hollow digestive viscera anastomotic or suture leaks. METHODS PubMed, Science Direct, Scopus and Cochrane searches were performed using the key words “anastomosis”, “colorectal/colonic anastomoses”, “anastomotic leak”, “stem cells”, “progenitor cells”, “cellular therapy” and “cell therapy” in order to identify relevant articles published in English and Spanish during the years of 2000 to 2021. Studies employing SCs, performing digestive anastomoses in hollow viscera or digestive perforation sutures and monitoring healing were finally included. Reference lists from the selected articles were reviewed to identify additional pertinent articles. Given the great variability in the study designs, anastomotic models, interventions (SCs, doses and vehicles) and outcome measures, performing a reliable meta-analysis was considered impossible, so we present the studies, their results and limitations. RESULTS Eighteen preclinical studies and three review papers were identified; no clinical studies have been published and there are no registered clinical trials. Experimental studies, mainly in rat and porcine models and occasionally in very adverse conditions such as ischaemia or colitis, have been demonstrated SCs as safe and have shown some encouraging morphological, functional and even clinical results. Mesenchymal SCs are mostly employed, and delivery routes are mainly local injections and cell sheets followed by biosutures (sutures coated by SCs) or purely topical. As potential weaknesses, animal models need to be improved to make them more comparable and equivalent to clinical practice, and the SC isolation processes need to be standardised. There is notable heterogeneity in the studies, making them difficult to compare. Further investigations are needed to establish the indications, the administration system, potential adjuvants, the final efficacy and to confirm safety and exclude definitively oncological concerns. CONCLUSION The future role of SC therapy to induce healing processes in digestive anastomoses/sutures still needs to be determined and seems to be currently far from clinical use.

show abstract

Section: Resultsmentioning

confidence: 99%

Stem cell therapy applied for digestive anastomosis: Current state and future perspectives

Trébol¹,

Georgiev-Hristov²,

Migueláñez³

et al. 2022

WJSC

View full text Add to dashboard Cite

show abstract

“…Ten records were further excluded for various reasons. Three studies were excluded due to focusing on biliary anastomoses (Hara et al [17], Zhang et al [18] and Ismail et al [19]), which were outside the scope of the present study. The study by Sukho et al [20] was excluded as it had duplicate data as a previous study by the same authors [21].…”

Section: Resultsmentioning

confidence: 99%

Stem Cell Therapies for Gastrointestinal Anastomotic Healing: A Systematic Review and Meta-Analysis on Results from Animal Studies

et al. 2022

View full text Add to dashboard Cite

Background: Despite considerable progress in surgical techniques, anastomotic leak (AL) is a common complication after gastrointestinal surgery. Stem cells are a promising therapy to improve healing and have been used in gastrointestinal anastomoses. In this study, we perform a systematic review and meta-analysis to evaluate the efficacy of stem cell therapies in preventing ALs among animal studies. Methods: A systematic review of the literature was performed by searching PubMed, Web of Science and the Cochrane Library. We considered all anastomoses of the gastrointestinal tract (excl. biliary), from the esophagus to the rectum. Outcomes included AL rates on postoperative day (POD) 7 and the latest time point reported. Results: Fourteen studies were identified, evaluating stem cells in gastrointestinal anastomoses, of which 1 was on esophageal, 2 on gastric, 2 on small intestinal and 9 on colorectal anastomoses. Meta-analysis did not show significant differences in AL rates on POD7 (OR 0.34 [95% CI: 0.04-3.15], p=0.248, I2=34.1% [95% CI: 0-75.2%], Q=6.07, df=4, p=0.194), but there was a non-significant trend for lower AL rates at the latest time point reported (OR 0.28 [95% CI: 0.08-1.01, p=0.052, I2=34% [95% CI: 0-70.8%], Q=10.6, df=7, p=0.157). Conclusion: Stem cell therapy may be associated with lower AL rates in gastrointestinal anastomoses, though meta-analysis is severely inhibited by heterogeneous study design. More studies are needed to determine the therapeutic potential of stem cells.

show abstract

Biliary stents for active materials and surface modification: Recent advances and future perspectives

Li,

Yuan,

Deng

et al. 2024

Bioactive Materials

View full text Add to dashboard Cite

Autologous Adipose Tissue–Derived Mesenchymal Stem Cells Introduced by Biliary Stents or Local Immersion in Porcine Bile Duct Anastomoses

Cited by 7 publications

References 29 publications

Stem cell therapy applied for digestive anastomosis: Current state and future perspectives

Stem cell therapy applied for digestive anastomosis: Current state and future perspectives

Stem Cell Therapies for Gastrointestinal Anastomotic Healing: A Systematic Review and Meta-Analysis on Results from Animal Studies

Biliary stents for active materials and surface modification: Recent advances and future perspectives

Contact Info

Product

Resources

About