Autoimplantation therapy for multiple warts

Abstract

This study demonstrates that homologous autoimplantation could be an effective, simple modality of treatment for multiple warts.

Study of Homologous Autoimplantation Therapy for Treatment of Multiple Warts in Patients Attending the Dermatology out Patient Department

“…A complete clearance of warts was observed in 34.69% patients in our study. Whereas, Shivakumar et al, Srivastava et al and Nischal et al observed a complete clearance of warts in 73.3%, 66.03% and 74.1% respectively 2,6,8 . However, a 67.74% reduction in the mean number of warts and a 48.71% reduction in the mean size of warts was observed in our study.…”

“…No treatment till date has been validated to be 100% effective in clearing viral warts. Hence, multiple treatment modalities have been tried with an average of 60-70% clearance of warts in 3 months time 6 . The ultimate wart treatment would resolve all or a great percentage of warts, be painless, need only one or a part of a wart treated, call for one to three treatments, create no scarring, offer HPV immunity for a lifetime and be available to all patients 9 .…”

“…The presence of local as well as systemic immunity may be necessary to eradicate the clinical manifestations of HPV infection 1 . Specific immune stimulation against HPV has been tried by autoimplantation of the wart tissue in the uninvolved skin 6,8 , injecting the suspension of the crushed wart into the muscle 2 or skin 10 and by quadrivalent HPV vaccines 8,11,12 . Patients with regression of warts either spontaneously or following successful therapy or injection of antigens showed the development of cell-mediated immunity and appearance of virus-specific IgM and IgG antibodies 10,13 .…”

“…Significant alterations occur in the immune status of patients during spontaneous wart regression or following successful wart therapy 6 . The most striking feature is the increase in viral-specific antibodies (both IgM and gG type).…”

“…In multiple warts, especially of face, alms and soles,destructive procedures are inappropriate and impractical.Homologous autoimplantation is a simple technique, which helps in inducing a good cell-mediated immune response, essential for clearance of warts 6 . The stimulation of the immune system byexposing the virus to immune mediators forms an ideal modality of treatment due to spontaneous regression of the wart with long-lasting immunity.…”