Autoimmunization and Lymphomagenesis in Parent‐F₁ Combinations Differing at the Major Histocompatibility Complex: Model for Spontaneous Disease Caused by Altered Self‐Antigens?

Chronic graft-versus-host disease-like autoimmune disorders spontaneously occurred in rats with neonatal thymus atrophy

“…Although several models of chronic GVHD have been reported [29][30][31] in which animals were given irradiation and lymphoid cell transplantation, influences of diverse factors including irradiation and acute GVHD complicated the pathogenesis in these models. FW-pX rats spontaneously developed chronic GVHD-like systemic autoimmune diseases, following abortive differentiation of T cells in the thymus at early ages in the newborn.…”

Graft-versus-Host Induced Immunosuppression and Tissue Injury: Experimental and Theoretical Considerations

“…The significance of these data defining NK cell activity in lym phoid tissue of GVH-reactive mice is equallyperplexing, although the findings could gen erate interesting speculation. It is to be noted that lymphomas which emerge in a setting of long-term GVH reactions [37] arise in sites (spleen, lymph nodes) of low NK activity. Contrariwise, thymic lymphomas have not been described in GVH-reactive mice.…”

Hapten Antibody Production and the Relevance of Allogeneic Reactions to Elimination of the Carrier Effect

“…Considerable evidence has accrued for mechanisms which provide potent stimula tion of the immune system, analogous to the GVH reaction, which occur during certain infectious processes [11]. Syngeneic 'allo geneic' reactions arising as a consequence of intercurrent infection are likely to be im portant triggers for the production of auto antibodies [12] or graft rejection [13].…”