Autoimmunity to neuronal nicotinic acetylcholine receptors

Pechlivanidou, Maria; Ninou, Elpinickie; Karagiorgou, Katerina; Tsantila, Aikaterini; Mantegazza, Renato; Francesca, Andreetta; Furlan, Raffaello; Dudeck, Leon; Steiner, Johann; Tzartos, John; Tzartos, Socrates

doi:10.1016/j.phrs.2023.106790

Cited by 11 publications

(8 citation statements)

References 106 publications

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“…This article mainly outlines the role of metal ions in the anti-tumor of TCM, but some ion receptors also deserve our attention. The receptors can be classified into ion channel receptors [149][150][151][152][153][154] , G protein-coupled receptors [155][156] , hormone-like receptors [149,157] , etc, according to their mechanism, such as protein structure, information transduction process, and nature of effect. These receptors have been reported to be able to influence pathophysiological states in a variety of diseases, such as neurological disorders [149][150][151][152] , cancer [152][153][154][155][156] , hypertension [157] , and vascular aging [149] .…”

Section: Discussionmentioning

confidence: 99%

“…The receptors can be classified into ion channel receptors [149][150][151][152][153][154] , G protein-coupled receptors [155][156] , hormone-like receptors [149,157] , etc, according to their mechanism, such as protein structure, information transduction process, and nature of effect. These receptors have been reported to be able to influence pathophysiological states in a variety of diseases, such as neurological disorders [149][150][151][152] , cancer [152][153][154][155][156] , hypertension [157] , and vascular aging [149] . It is worth noting that although studies have shown that some receptors have therapeutic potential in anti-tumor, but whether they can become drug targets for cancer treatment is still unclear.…”

Section: Discussionmentioning

confidence: 99%

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Metal Ions in Cancer Prevention and Treatment with Traditional Chinese Medicine

Wang,

Myrzagali,

Xie

et al. 2023

Acupuncture and Herbal Medicine

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Malignant tumor has become a major threat affecting human health, and is one of the main causes of human death. Recent studies have shown that many traditional Chinese medicines (TCM) have good anti-tumor activity, which may improve the therapeutic effect of routine treatment and quality of life with lower toxicity. However, the efficacy of TCM alone for the treatment of tumors is limited. Metal ions are essential substances for maintaining normal physiological activities. This article summarized the multiple mechanisms in which metal ions are involved in the prevention and treatment of tumors in TCM.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Metal Ions in Cancer Prevention and Treatment with Traditional Chinese Medicine

Wang,

Myrzagali,

Xie

et al. 2023

Acupuncture and Herbal Medicine

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“…It is now evident that nAChRs not only play an important role in neuronal function and the addiction to nicotine [ 151 , 152 ] but may also serve as targets for therapeutic intervention in various neuropsychiatric/neurodegenerative disorders, including PD [ 25 , 153 , 154 ], depression [ 153 , 155 , 156 ], obsessive–compulsive disorder [ 157 , 158 ], ADHD [ 159 ], Tourette syndrome [ 160 , 161 , 162 ], mild cognitive impairment or Alzheimer’s disease [ 163 , 164 , 165 , 166 ], ischemia [ 167 ], catalepsy [ 168 ], schizophrenia [ 4 , 166 , 169 ], pain [ 147 , 170 ], energy balance [ 171 , 172 ], autoimmune disorders [ 173 ], and even sleep–wake cycle dysregulation [ 174 ]. These receptors are also expressed abundantly in a variety of immune cells, including B cells, T cells, macrophages, and microglia, and are believed to contribute to the anti-inflammatory effects of nicotine [ 175 , 176 , 177 , 178 ].…”

Section: Nachrsmentioning

confidence: 99%

Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson’s Disease

Soares,

Costa,

Ferrolho

et al. 2024

Cells

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Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by resting tremor, bradykinesia, rigidity, and postural instability that also includes non-motor symptoms such as mood dysregulation. Dopamine (DA) is the primary neurotransmitter involved in this disease, but cholinergic imbalance has also been implicated. Current intervention in PD is focused on replenishing central DA, which provides remarkable temporary symptomatic relief but does not address neuronal loss and the progression of the disease. It has been well established that neuronal nicotinic cholinergic receptors (nAChRs) can regulate DA release and that nicotine itself may have neuroprotective effects. Recent studies identified nAChRs in nonneuronal cell types, including glial cells, where they may regulate inflammatory responses. Given the crucial role of neuroinflammation in dopaminergic degeneration and the involvement of microglia and astrocytes in this response, glial nAChRs may provide a novel therapeutic target in the prevention and/or treatment of PD. In this review, following a brief discussion of PD, we focus on the role of glial cells and, specifically, their nAChRs in PD pathology and/or treatment.

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“…It is now evident that nAChRs not only play an important role in neuronal function and addiction to nicotine [151,152], but may also serve as targets for therapeutic intervention in various neuropsychiatric/neurodegenerative disorders including PD [25,153,154], depression [153,155,156], obsessive-compulsive disorder [157,158] , ADHD [159], Tourette syndrome [160][161][162], mild cognitive impairment or Alzheimer's disease [163][164][165][166], ischemia [167], catalepsy [168], schizophrenia [4,166,169], pain [147,170], energy balance [171,172], autoimmune disorders [173], and even in sleepwake cycle dysregulation [174]. These receptors are also expressed abundantly in a variety of immune cells including B cells, T cells, macrophages, and microglia, and are believed to contribute to the antiinflammatory effects of nicotine [175][176][177][178].…”

Section: Nachrsmentioning

confidence: 99%

Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson’s Disease

Soares,

Costa,

Ferrolho

et al. 2024

Preprint

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Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by resting tremor, bradykinesia, rigidity, postural instability, that also includes non-motor symptoms such as mood dysregulation. Dopamine (DA) is the primary neurotransmitter involved in this disease, but cholinergic imbalance has also been implicated. Current intervention in PD is focused on replenishing central DA, which provides remarkable temporary symptomatic relief but does not address the neuronal loss and the progression of the disease. It has been well established that neuronal nicotinic cholinergic receptors (nAChRs) can regulate DA release and that nicotine itself may have neuroprotective effects. Recent studies have identified nAChRs in nonneuronal cell types including glial cells, where they may regulate inflammatory responses. Given the crucial role of neuroinflammation in dopaminergic degeneration, and the involvement of microglia and astrocytes in this response, glial nAChRs may provide a novel therapeutic target in prevention and/or treatment of PD. In this review, following a brief discussion of PD, we focus on the role of glial cells and specifically their nAChRs in PD pathology and/or treatment.

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Autoimmunity to neuronal nicotinic acetylcholine receptors

Cited by 11 publications

References 106 publications

Metal Ions in Cancer Prevention and Treatment with Traditional Chinese Medicine

Metal Ions in Cancer Prevention and Treatment with Traditional Chinese Medicine

Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson’s Disease

Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson’s Disease

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