Autoimmunity and Parasites

Papazahariadou, M.; Kalogeromitros, D.; Athanasiadis, Georgios; Pfab, Florian; Symeonidou, Isaia; Caraffa, Auro; Anogeianaki, A.; Tetè, Stefano; Cerulli, Giuliano Giorgio; Salini, Vincenzo; Castellani, M.L.; Lutiis, Maria Anna De; Conti, Francesca; Frydas, S.

doi:10.1177/039463200802100102

Int J Immunopathol Pharmacol

2008

DOI: 10.1177/039463200802100102

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Autoimmunity and Parasites

M. Papazahariadou

D. Kalogeromitros

Georgios Athanasiadis

et al.

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Cited by 5 publications

(3 citation statements)

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“…One is DP, which is better characterized (the POD receptor) and the other is chemoattractant receptor-homologous molecule expressed on Th2 (CRTH2) (26)(27)(28). Pharmacological blockade or genetic ablation of DP e/or CRTH2 is associated with a reduction in tissue inflammation (29)(30)(31)(32)(33).…”

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confidence: 99%

Mast Cells and Arachidonic Acid Cascade in Inflammation

et al. 2009

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Prostaglandin D2 PGD2 is a major cyclooxygenase metabolite of arachidonic acid produced by mast cells and it is released following allergen challenge in diseases, such as allergic diseases. PGD2 may act as a neuromodulator and as an allergic and inflammatory mediator. In allergic diseases, activated mast cell synthesizes prostaglandin D2 (first cyclo-oxygenate mediator) which has bronchoconstrictive and vasodilating effects and attracts several leukocytes. It has been found that activated mast cells, challenged with physiological and non- physiological secretagogues, release elevated histamine and tryptase and chymase, leukotrienes B4, C4 and D4, 5-hydroxyeicosatetraenoic acid, PGD2, Platelet Activating Factor (PAF), heparin, and high-molecular-weight neutrophil chemotactic factor and cytokines/chemokines. PGD2 exerts its biological activity through the DP and CRTH2 receptors and their cDNA cloning which were characterized 15 years ago. In this report, we revisited the biological effects of arachidonic acid compounds released by activated mast cells in allergic and inflammatory states.

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Mast Cells and Arachidonic Acid Cascade in Inflammation

et al. 2009

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“…Substance P is an l l-amino acid neuropeptide that is released from nerve endings in many tissues, and belongs to a family of related peptides called tachykinins and plays critical roles in immuneregulation in human and animal models (48). Other three related tachykinins are known, substance K, neuromedin K and hemokinin, which also have some biological activity in immunity and inflammation (48)(49)(50).…”

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Inflammatory Compounds: Neuropeptide Substance Pand Cytokines

et al. 2009

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Inflammatory diseases represent one of the major causes of morbidity and mortality throughout the world and they affect the functions of several tissues. The pathophysiology of these diseases involves release of many pro-inflammatory mediators such as cytokines/chemokines, histamine, C3a, C5a (complement components), bradykinin, leukotrienes (LTC4, LTD4, LTE4), PAF, and substance P, in addition to anti-inflammatory molecules. Recently, it has been demonstrated that neuroimmune interactions are important in the initiation and progress of inflammatory processes. Substance P is an 11-amino acid neuropeptide that is released from nerve endings in many tissues. It acts via membrane-bound NK1 receptors (NK1R). Inflammatory and neuropeptides such as substance P stimulate the release of chemokines, in particular IL-8, a potent neutrophil chemoattractant. Expression of IL-8 is regulated mainly by the transcription factors NF-kappaB, activating protein-1. Substance P plays an important role in immunological and inflammatory states, and it is a mediator of tissue injury, asthma, arthritis, allergy and autoimmune diseases. In this article, our studies revisited the interrelationship between these two powerful inflammatory compounds: substance P and cytokines. These observations suggest that these inflammatory molecules may represent a potential therapeutic target to treat several inflammatory states.

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“…Pro-inflammatory cytokines are important mediators of inflammation, immunity, proteolysis, cell recruitment, and proliferation (6)(7)(8)(9)(10)(11). IL-32 is a newly described cytokine produced mainly by T, NK cells, and epitheliod cells that has the properties of a classic pro-inflammatory mediator (12)(13)(14)(15)(16). where the gene resides in chromosome 16 is capable of inducing TNFa., IL-8 and MIP-2 (macrophage inflammatory protein) in several types of cells (17)(18)(19)(20)(21).…”

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Impact of IL-32 on Histamine Release by Human Derived Umbilical Cord Blood Mast Cells

et al. 2009

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IL-32 is onae of the last important cytokines discovered, produced mainly by T cells, natural killer cells, and epithelial cells. Probably many other different cells are a source oflL-32, which has been found to be a powerful pro-inflammatory mediator. Here we studied the effect of IL-32 on histamine release by human-derived cord-blood mast cells. In these studies we found that IL-32 significantly stimulates the release of histamine only at high concentrations (100 ng/ml) while at 10 or 50 ng/ml it had no effect. These results were found for the first time and demonstrate that IL-32 may play an important role in allergic and inflammatory diseases.

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Autoimmunity and Parasites

Cited by 5 publications

References 32 publications

Mast Cells and Arachidonic Acid Cascade in Inflammation

Mast Cells and Arachidonic Acid Cascade in Inflammation

Inflammatory Compounds: Neuropeptide Substance Pand Cytokines

Impact of IL-32 on Histamine Release by Human Derived Umbilical Cord Blood Mast Cells

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