Autoimmunity and Increased c-
            <i>myb</i>
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Mountz, J D; Steinberg, A D; Klinman, D M; Smith, H. H.; Mushinski, J F

doi:10.1126/science.6494925

Cited by 89 publications

(35 citation statements)

References 21 publications

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“…For example, a chromosomal translocation could result in constitutive activation ofa growthpromoting substance, perhaps encoded by an oncogene, as has been suggested for a number ofhematopoietic malignancies (30). Such an activation ofthe cellular oncogene c-myb has been previously reported in patient 2 from this series (31). It is hypothesized by analogy that Burkitt's lymphoma arises in a setting of chronic Epstein-Barr virus stimulation, in which B cells undergoing repeated rounds of cell division are at risk of a chromosomal translocation involving the c-myc oncogene and one of the immunoglobulin genes (32,33).…”

Section: Methodsmentioning

confidence: 91%

Clonality of angioimmunoblastic lymphadenopathy and implications for its evolution to malignant lymphoma.

Lipford¹,

Smith²,

Pittaluga³

et al. 1987

J. Clin. Invest.

131

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Section: Methodsmentioning

confidence: 91%

Clonality of angioimmunoblastic lymphadenopathy and implications for its evolution to malignant lymphoma.

Lipford¹,

Smith²,

Pittaluga³

et al. 1987

J. Clin. Invest.

131

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“…Increased c-myb expression is found in lymph node cells from MRL-lprllpr and gldlgld autoimmune mice; these lymph nodes are populated with activated T cells (11)(12)(13). B lymphocytes from New Zealand black and BXSB mice express increased quantities of c-myc and N-ras proto-oncogenes (12).…”

Section: Discussionmentioning

confidence: 99%

Increased proto‐oncogene expression in peripheral blood T lymphocytes from patients with systemic sclerosis

Kahan

Gerfaux

Kahan

et al. 1989

Arthritis & Rheumatism

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The expression of c-myc, c-myb, and eras protooncogenes, determined using RNA hybridization techniques (slot-blot), was significantly increased in peripheral blood T lymphocytes, but not in B cells, from 17 patients with systemic sclerosis with diffuse scleroderma, compared with the expression in normal control subjects. The magnitude of expression of c-myc and c-myb tended to be higher in patients with early, active disease. These results demonstrate an in vivo activation of T cells from systemic sclerosis patients, which may play an important role in the pathogenesis of the disease.The etiology and pathogenesis of systemic sclerosis (SSc; scleroderma) have not been well elucidated. The disease is characterized by vascular and microvascular abnormalities (1,2), excessive fibroblastic activity (3), and collagen deposition in numerous organs (4), which might be induced by immunologic defects. A wide range of immunologic abnormalities have been described in association with SSc, including decreased numbers of circulating T lymphocytes (3, decreased From INSERM U-283 and the

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“…Though MRL-+/+ mice have much less severe autoimmune disease than do congenic MRLlprllpr (19,27,28), both mouse strains had similar levels of 8.4-kb MCF RNA. Thus, lpr did not increase 8.4-kb MCF expression on an autoimmune background.…”

Section: Discussionmentioning

confidence: 98%

Expression of an endogenous retroviral transcript is associated with murine lupus

Krieg¹,

Khan²,

Steinberg³

1989

Arthritis & Rheumatism

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We have been investigating whether murine lupus is associated with endogenous type C retroviral expression. We used Northern blot analyses and oligonucleotide probes, which are able to distinguish the envelope genes of the xenotropic and mink cell focusforming (MCF) classes of type C retroviruses. Xenotropic expression in the spleen varied markedly among inbred mouse strains; although all strains expressed a 1.8‐kb transcript, only one‐half expressed one or more larger transcripts (8.4, 7.2, and/or 3.0 kb). Autoimmune disease did not correlate with expression of any of the xenotropic transcripts. Xenotropic and MCF transcripts were expressed independently among the mouse strains studied. Splenic RNA from all strains contained 7.2‐, 3.0‐, and 1.8‐kb MCF transcripts. Some strains also expressed 8.4‐kb MCF splenic RNA. There was a strong association between murine lupus and expression of 8.4‐kb MCF transcripts: 6 of 6 lupus‐prone strains, but only 2 of 11 nonautoimmune strains, had detectable 8.4‐kb MCF RNA. The xid and Yaa mutations had minimal effects on expression of 8.4‐kb MCF‐related transcripts, despite their major and opposite effects on disease. Moreover, New Zealand black mice highly expressed this RNA from day 1 of life, before disease development. The data suggest that expression of 8.4‐kb MCF endogenous retroviral transcripts is a primary feature of murine lupus and is not secondary to disease expression.

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Autoimmunity and Increased c- myb Transcription

Cited by 89 publications

References 21 publications

Clonality of angioimmunoblastic lymphadenopathy and implications for its evolution to malignant lymphoma.

Clonality of angioimmunoblastic lymphadenopathy and implications for its evolution to malignant lymphoma.

Increased proto‐oncogene expression in peripheral blood T lymphocytes from patients with systemic sclerosis

Expression of an endogenous retroviral transcript is associated with murine lupus

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