Autoimmunity and autoinflammation as the yin and yang of idiopathic recurrent acute pericarditis

Causes systémiques ou originales de douleurs thoraciques

“…Des maladies périodiques (fièvres « méditerranéennes », mais qui peuvent aussi concerner jusqu'à des Japonais) peuvent être à l'origine de douleurs thoraciques intermittentes (pleurésies et/ou péricardites aiguës et récidivantes [46]), qui ne sont parfois rapportées à leur vraie origine que tardivement. Il en est de même pour les syndromes TRAPS (liés à une mutation du récepteur au TNF-R1).…”

Clinical Applications of Late Gadolinium in Children

“…This fact makes LGE very useful to guide the tapering of the anti-inflammatory therapy. In pericardial constriction, a complication secondary to chronic pericarditis that requires pericardiectomy as the definitive treatment, if CMR shows LGE as evidence of pericardial inflammation the constriction might be reversible with aggressive anti-inflammatory therapy, thus obviating the need for surgery (14,15). So LGE have important diagnostic and therapeutic implications in the context of pericarditis.…”

Colchicine and beyond: New options for the treatment of pericarditis

“…Thus, a substantial treatment gap still exists. It has been hypothesized that many patients with recurrent pericarditis without an obvious cause suffer from an immune-mediated disorder [12,13], either from its onset or incited by an initial viral infection. In addition to the fact that immunomodulatory treatment is usually effective, the existence of an immune response underlying recurrent pericarditis is supported by the presence of elevated levels of autoantibodies in patients compared with control subjects as well as an association with specific leukocyte antigens [14][15][16].…”