2014
DOI: 10.1111/jdv.12577
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Autoimmune thyroiditis and isotretinoin: real association or coincidence?

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Cited by 5 publications
(3 citation statements)
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References 6 publications
(7 reference statements)
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“…On a separate note, in 2014, Guerouaz et al reported a case on 2-year-old twin brothers who were treated with isotretinoin for inflammatory acne conglobate. The twins developed autoimmune thyroiditis [7]. In both these cases, either patients had a negative family history of autoimmune thyroid disease or no family history was recorded.…”
Section: Discussionmentioning
confidence: 99%
“…On a separate note, in 2014, Guerouaz et al reported a case on 2-year-old twin brothers who were treated with isotretinoin for inflammatory acne conglobate. The twins developed autoimmune thyroiditis [7]. In both these cases, either patients had a negative family history of autoimmune thyroid disease or no family history was recorded.…”
Section: Discussionmentioning
confidence: 99%
“…Isotretinoin has an immunomodulatory effect through its role in apoptosis and activation of B and T lymphocytes 19 . This effect was suspected to trigger some autoimmune diseases such as diabetes 20 .…”
Section: Discussionmentioning
confidence: 99%
“…It is well known to cause central hypothyroidism, but isotretinoin has not shown this affinity. Thyroid abnormalities secondary to isotretinoin have been reported since the 1980s, 60–65 but the number of cases is small, and no pattern of timeline or abnormalities has emerged to support causation. Since the 1980s prospective cohort studies have followed patients receiving isotretinoin to investigate the influence of isotretinoin on hormonal homeostasis 48,65–69 .…”
Section: Methodsmentioning
confidence: 99%