Autoimmune thyroid disorders

Antonelli, Alessandro; Ferrari, Silvia; Corrado, Alda; Domenicantonio, Andrea Di; Fallahi, Poupak

doi:10.1016/j.autrev.2014.10.016

Cited by 682 publications

(670 citation statements)

References 94 publications

(94 reference statements)

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“…Such a disruption might play a role in the increased incidence of various medical conditions in shift workers, such as the increased risk for infections, autoimmune diseases, cancer, and cardiovascular and metabolic disorders (2,(8)(9)(10)(11)(12)(13). Interestingly, an increased prevalence of autoimmune conditions, such as multiple sclerosis and autoimmune thyroid disorders, was associated with shift work (11,12,(60)(61)(62)(63). In autoimmune thyroid disorders, there is an increase in the recruitment of Th1 lymphocytes in thyroid tissue (based on changes in cell trafficking between blood and tissues), leading to an increase in the production of IFN-g and TNF-a, further stimulating the recruitment of Th1 lymphocytes and initiating an amplification feedback loop (63).…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, an increased prevalence of autoimmune conditions, such as multiple sclerosis and autoimmune thyroid disorders, was associated with shift work (11,12,(60)(61)(62)(63). In autoimmune thyroid disorders, there is an increase in the recruitment of Th1 lymphocytes in thyroid tissue (based on changes in cell trafficking between blood and tissues), leading to an increase in the production of IFN-g and TNF-a, further stimulating the recruitment of Th1 lymphocytes and initiating an amplification feedback loop (63). Because a cascade of events is implicated in this process, the timing of each of these events might be important; thus, it is possible that the lack of temporal coordination among the different immune functions seen during night shifts creates a state in which this amplification phenomenon could be favored.…”

Section: Discussionmentioning

confidence: 99%

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Simulated Night Shift Disrupts Circadian Rhythms of Immune Functions in Humans

Cuesta

Boudreau

Dubeau-Laramée

et al. 2016

The Journal of Immunology

107

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Recent research unveiled a circadian regulation of the immune system in rodents, yet little is known about rhythms of immune functions in humans and how they are affected by circadian disruption. In this study, we assessed rhythms of cytokine secretion by immune cells and tested their response to simulated night shifts. PBMCs were collected from nine participants kept in constant posture over 24 h under a day-oriented schedule (baseline) and after 3 d under a night-oriented schedule. Monocytes and T lymphocytes were stimulated with LPS and PHA, respectively. At baseline, a bimodal rhythmic secretion was detected for IL-1β, IL-6, and TNF-α: a night peak was primarily due to a higher responsiveness of monocytes, and a day peak was partly due to a higher proportion of monocytes. A rhythmic release was also observed for IL-2 and IFN-γ, with a nighttime peak due to a higher cell count and responsiveness of T lymphocytes. Following night shifts, with the exception of IL-2, cytokine secretion was still rhythmic but with peak levels phase advanced by 4.5–6 h, whereas the rhythm in monocyte and T lymphocyte numbers was not shifted. This suggests distinct mechanisms of regulation between responsiveness to stimuli and cell numbers of the human immune system. Under a night-oriented schedule, only cytokine release was partly shifted in response to the change in the sleep–wake cycle. This led to a desynchronization of rhythmic immune parameters, which might contribute to the increased risk for infection, autoimmune diseases, cardiovascular and metabolic disorders, and cancer reported in shift workers.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Simulated Night Shift Disrupts Circadian Rhythms of Immune Functions in Humans

Cuesta

Boudreau

Dubeau-Laramée

et al. 2016

The Journal of Immunology

107

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“…However, only a small minority of studies was excluded specifically because they were not in English. Another limitation of our study is that diagnosis of particular AITD has not been covered, although the association of HT with anti-thyroid antibodies and hypothyroidism has been well-established [37].…”

Section: Discussionmentioning

confidence: 99%

Thyroid Disturbance in Patients with Chronic Hepatitis C Infection: A Systematic Review and Meta-analysis

Shen

Wang

Xie

et al. 2016

JGLD

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Background & Aims: The involvement of thyroid autoimmunity and dysfunction in patients with chronichepatitis C virus (HCV) infection before interferon-α (IFN-α) therapy remains controversial. We performedthis meta-analysis to evaluate the association of HCV infection with the presence of anti-thyroid antibodiesand dysthyroidism. Methods: A literature search was carried out to collect articles dated up to August 2015 to identify observationalstudies which compared the prevalence of anti-thyroid antibodies and thyroid dysfunction in IFN-α naïvechronic HCV-infected subjects with non-HCV infected controls. Random-effect or fixed-effect meta-analyseswere applied and results reported as odds ratios (ORs) with 95% confidence intervals (CIs). Results: Twelve studies were included, involving 1,735 HCV-infected and 1,868 non-HCV infected subjects.Pooled anti-thyroid antibody prevalence tended to be higher in HCV-infected subjects. The prevalence ofanti-thyroglobulin antibody (TGAb), anti-thyroid peroxidase antibody (TPOAb), anti-thyroid microsomalantibody (ATMA) were 2.40-fold, 1.96-fold and 1.86-fold higher in HCV-infected subjects than in controls,respectively. The prevalence of hypothyroidism also differed by HCV infection status, with a pooled risk of3.10 (95%CI: 2.19-4.40) in HCV-infected subjects. However, the results did not show a significant differencein the prevalence of hyperthyroidism between the two groups.Conclusion: Chronic HCV infection may be an independent risk factor for thyroid disturbance. It is advisablefor the clinicians to monitor both thyroid antibodies and function in the course of chronic HCV infection,independent of IFN-α treatment. Abbreviations: AITD: autoimmune thyroid disease; ATMA: anti-thyroid microsomal antibody; CHC:chronic hepatitis; GD: Graves’ disease; HCV: hepatitis C virus; HT: Hashimoto’s thyroiditis; IFN-α: interferonalpha;NOS: Newcastle-Ottawa quality assessment scale; T3: triiodothyronine; T4: thyroxine; TGAb: antithyroglobulinantibody; TPOAb: anti-thyroid peroxidase antibody.

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“…Both the main types of AITDs, Hashimoto's Thyroiditis (HT) and Graves' Disease (GD), are characterized by lymphocytic infiltration of the parenchyma. The prevalence of AITDs is estimated to be about 5% in the general population, with a female/male ratio of 4-10/1; the prevalence of thyroid auto-antibodies without clinical manifestations is probably higher [9]. Antibodies to thyroperoxidase (TPO-Ab) are considered the most sensitive serological marker of HT and probably they also have a correlation with the grade of lymphocyte infiltration within the thyroid gland [10].…”

Section: Thyroid Cancer and Autoimmunity: Epidemiological And Clinicamentioning

confidence: 99%

“…From an epidemiological perspective, female sex and iodine levels are key factors in the development of both AITDs and thyroid nodules [9].…”

Section: Thyroid Cancer and Autoimmunity: Epidemiological And Clinicamentioning

confidence: 99%

Thyroid Autoimmunity and Cancer

Felicetti¹,

Catalano²,

Fortunati³

2017

Frontiers of Hormone Research

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Cancer and autoimmune diseases are often associated in the same individual. The functional link between immune system and cancer development is only partially known. Even though the immune system can control the development of cancer through immune surveillance, cancer cell itself can escape immune surveillance. Actually, it is debated whether autoimmune diseases have to be regarded as cancer cause or its consequence.In particular, autoimmune thyroiditis and thyroid cancer (in particular, papillary thyroid cancer) are a fascinating model of this complex relationship. In the present review, we describe what has been reported by now in literature about autoimmune thyroiditis and papillary thyroid cancer, and on the basis of available data, we try to clarify the present knowledge.

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Autoimmune thyroid disorders

Cited by 682 publications

References 94 publications

Simulated Night Shift Disrupts Circadian Rhythms of Immune Functions in Humans

Simulated Night Shift Disrupts Circadian Rhythms of Immune Functions in Humans

Thyroid Disturbance in Patients with Chronic Hepatitis C Infection: A Systematic Review and Meta-analysis

Thyroid Autoimmunity and Cancer

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