Autoimmune thyroid disorders during anti-TNF alpha therapy: Coincidence, paradoxical event or marker of immunogenicity?

Pascart, Tristan; Ducoulombier, Vincent; Roquette, Diane; Périmenis, P.; Coquerelle, Pascal; Maury, Frédéric; Baudens, Guy; Morel, Gauthier; Deprez, X.; Flipo, René‐Marc; Houvenagel, É.

doi:10.1016/j.jbspin.2013.11.007

Cited by 12 publications

(8 citation statements)

References 8 publications

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“…To the best of our knowledge, there are only a few cases reporting SAT after adalimumab treatment. Pascart T et al . reported a patient with SAT and rheumatoid arthritis 6 years after adalimumab treatment.…”

Section: Discussionmentioning

confidence: 99%

“…also described SAT in a patient with PsA after adalimumab treatment, 40 mg every other week for 10 months. Other tumor necrosis factor (TNF)‐ α inhibitors such as infliximab and etanercept are also associated with SAT …”

Section: Discussionmentioning

confidence: 99%

“…Anti‐TNF‐ α therapy may also contribute to other thyroid diseases, such as Graves' disease, Hashimoto's thyroiditis, amyloid goiter, and papillary thyroid carcinoma . Allanore et al .…”

Section: Discussionmentioning

confidence: 99%

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Subacute thyroiditis in a patient with psoriasis treated with a tumor necrosis factor‐α inhibitor

2018

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CaseA 41-year-old woman has a 26-year history of psoriasis vulgaris and psoriatic arthritis (PsA). Initially, multiple erythematous to brownish thick scaly plaques and papules were observed over her limbs (Fig. 1). Subsequently, arthralgia developed bilaterally over the knees and progressed to the hands and feet. X-ray films revealed subluxation and deformity of the small hand joints (Fig. 2). Her past medical history was otherwise unremarkable.She received topical steroid, calcipotriol, and broadband ultraviolet B therapy, but the disease persisted with intermittent flare-ups. Methotrexate was prescribed, but active arthritis over the hands, elbows, and right ankle were persistent, hence rheumatologists switched to leflunomide for PsA treatment. Nevertheless, the progression of joint deformities and swelling continued. She was subsequently shifted to adalimumab subcutaneous injection (40 mg every other week).However, she experienced an intermittent cough for 7 months after adalimumab initiation. Three weeks after discontinuation of adalimumab, episodic fever up to 38°C with an intermittent sore throat occurred for 1 week. Subsequently, the symptoms worsened with anterior neck tenderness, low-grade fever, and submandibular lymphadenopathy in the next week.Restless hand tremors and palpitations were also observed.Laboratory data showed thyroid-stimulating hormone (TSH), 0.006 mU/l; T 3 , 3.9 nmol/l; T 4 , >308.9 nmol/l; free T 4 , 52.6 pmol/l; and erythrocyte sedimentation rate, 89 mm/h. The results of a serology survey for influenza infection were Figure 1 Multiple erythematous to brownish thick scaly plaques and papules over the patient's upper limbs ª

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Subacute thyroiditis in a patient with psoriasis treated with a tumor necrosis factor‐α inhibitor

2018

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“…Atzeni et al, in a study of 20 patients (including six with positive ATPO and eight with positive aTG) with rheumatoid arthritis, showed a change in ATPO from positive to negative in one of the patients after six months of treatment with adalimumab [28]. Pascart et al examining patients treated with anti-TNF-α due to rheumatological diseases in their centre, described 11 cases of development of AITD, including six cases of Graves' disease, three cases of Hashimoto's disease, and two cases of subacute thyroiditis [29]. Raterman et al, in a group of 138 patients with rheumatoid arthritis, after six months of treatment with adalimumab, described a change in the ATPO titre from positive to negative in one of 21 patients with a positive ATPO at baseline.…”

Section: Aim Of the Studymentioning

confidence: 99%

Anti-tumour necrosis factor α therapy – Does it increase the risk of thyroid disease or protect against its development?

Furtak

Wędrychowicz

Starzyk

2020

pedm

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“…Норма для исследуемых цитокинов в сыворотке крови составляет 0-5 пг/мл. Известно, что содержание цитокинов, в частности TNF-α, увеличивается прямо пропорционально активности воспалительного процесса [15].…”

Section: The State Of T-and B-cellular Immunity In Children With Auunclassified

The effect of selenium on the immune status in the complex treatment of children with autoimmune thyroiditis

Г.Г.Габулов

Джабраилова

2019

Ross. vestn. perinatol. pediatr.

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The authors studied the effect of selenium on the dynamics of immune system indicators in children with autoimmune thyroiditis. They examined 31 children (average age of 11.16 ± 0.59 years). Group I included 17 children who took selenium (100 μg per day for 6 months) along with the basic treatment. Group II (n=14) took L-thyroxin. The control group included 15 healthy children of the same age. The average level of selenium in children of Group I and II was 69.23 ± 1.52 μg / l at the beginning of the study, in the control group it was 114.8 ± 3.18 μg / l. Before treatment, children in Group I and II had T-cell suppression, the average level of all cytokines (especially TNF-α and IL-6) was significantly higher than in practically healthy children. The study demonstrated that the level of the thyroid tissue antibodies decreased significantly (p=0.001) with an increase in the level of selenium in the blood serum. By the end of the study the content of IgA (p=0.012) and IgG (p=0.044) in Group I, as well as the number of lymphocytes CD3 + (p=0.008), CD4 + (p=0.015), CD16 + / 56 + (p=0.010) significantly increased. The authors observed statistically significant decrease in the levels of TNF-α (p=0.028), IL-6 (p=0.002) and IL-1β (p=0.009) in children who took selenium in addition to the main treatment. Thus, the results of the study suggest that selenium in the complex therapy of autoimmune thyroiditis significantly reduces the titer of antithyroid antibodies and positively affects a number of important indicators of immune homeostasis in children.

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Autoimmune thyroid disorders during anti-TNF alpha therapy: Coincidence, paradoxical event or marker of immunogenicity?

Cited by 12 publications

References 8 publications

Subacute thyroiditis in a patient with psoriasis treated with a tumor necrosis factor‐α inhibitor

Subacute thyroiditis in a patient with psoriasis treated with a tumor necrosis factor‐α inhibitor

Anti-tumour necrosis factor α therapy – Does it increase the risk of thyroid disease or protect against its development?

The effect of selenium on the immune status in the complex treatment of children with autoimmune thyroiditis

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