Autoimmune thyroid diseases and Th17/Treg lymphocytes

Shao, Shiying; Yu, Xuefeng; Shen, Liya

doi:10.1016/j.lfs.2017.11.026

Cited by 60 publications

(52 citation statements)

References 95 publications

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“…Figure S1 shows the triptolide affected the infiltration of lymphocytes in colon tissues. Studies have shown that the imbalance between Th1/Th2 and Th17/Treg cell population results in changes in expression levels of proinflammatory and anti-inflammatory factors, thereby causing lymphocyte infiltration and B cell activation (Bliddal et al, 2017;Shao et al, 2018). This phenomenon plays a crucial role in the pathogenesis of UC.…”

Section: Discussionmentioning

confidence: 99%

Effect of Triptolide on Dextran Sodium Sulfate-Induced Ulcerative Colitis and Gut Microbiota in Mice

Rao

et al. 2020

Front. Pharmacol.

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Triptolide is beneficial for the treatment of ulcerative colitis (UC), which is closely related to the gut microbiota. However, whether the therapeutic effects of triptolide involve the regulation of the gut microbiota is still unclear. In the present study, animal models of UC mice induced by dextran sodium sulfate (DSS) were established, the changes of gut microbiota in mice were detected by high-throughput sequencing. The effects of triptolide on DSS-induced UC mouse and its gut microbiota were studied. As a result, we found that triptolide exerted anti-inflammatory and therapeutic effects on UC mice. Sequencing results for the gut microbiota showed that the composition of the gut microbiota from DSS group was disordered as compared with that from the control group, consistent with a decrease in the abundance of flora. Triptolide treatment accelerated the recovery of the population of the gut microbiota and significantly improved the microbial diversity. At the phylum level, the population of Bacteroidetes decreased and that of Firmicutes increased. At the genus level, Bacteroides and Lachnospiraceae counts decreased. Thus, triptolide could regulate the composition of the gut microbiota, accelerate the recovery of microbiota, and exert good therapeutic effects in UC mice. Our results also revealed that fecal transplantation from triptolide-treated mice could relieve UC. This study provides a reference for the rational use of triptolide for the treatment of UC.

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Section: Discussionmentioning

confidence: 99%

Effect of Triptolide on Dextran Sodium Sulfate-Induced Ulcerative Colitis and Gut Microbiota in Mice

Rao

et al. 2020

Front. Pharmacol.

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“…IL-17-producing CD4(+) T cells (Th17 cells), the proliferation of which is regulated by IL-6, IL-23, and transforming growth factor (TGF)-β, play an important role in the pathogenesis of autoimmune inflammation; while regulatory T (Treg) lymphocytes exert their immunosuppressive effect by means of direct cell-to-cell interaction or through secretion of cytokines such as TGF-β and IL-10 (Shao, Yu, & Shen, 2018).…”

Section: Cd4(+) and Cd8(+) T Cellsmentioning

confidence: 99%

Dipeptidyl peptidase 4 inhibitors and their potential immune modulatory functions

Shao

et al. 2020

Pharmacology & Therapeutics

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152

129

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“…Clostridia clusters IV and XIVa promote Treg differentiation [17,18], and Lactobacillus rhamnosus [19] convert mucosal dendritic cells toward tolerogenic profiles via secreting IL-10 and TGF-β. Although gut microbiota has been identified as a trigger for mucosal Treg/Th17 balance and is sufficient to promote autoimmunity in murine models [20], no microbial promoter of Treg has yet been found to be associated with occurrence of human adenoma or colorectal adenocarcinoma (CRC). However, there is emerging data to link different bacteria, such as Faecalibacterium prausnitzii (F. prausnitzii), Bifidobacterium longum (B. longum), and Bacteroides fragilis, to their ability to induce T cell differentiation and cytokine production in the development of CRC [21,22].…”

Section: Introductionmentioning

confidence: 99%

YYFZBJS ameliorates colorectal cancer progression in ApcMin/+ mice by remodeling gut microbiota and inhibiting regulatory T-cell generation

Sui

Zhang

et al. 2020

Cell Commun Signal

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Background: Progression of Colorectal cancer (CRC) is influenced by single or compounded environmental factors. Accumulating evidence shows that microbiota can influence the outcome of cancer immunotherapy. T cell, one of the main populations of effector immune cells in antitumor immunity, has been considered as a double-edged sword during the progression of CRC. Our previous studies indicate that traditional Chinese herbs (TCM) have potential anticancer effects in improving quality of life and therapeutic effect. However, little is known about the mechanism of TCM formula in cancer prevention. Methods: Here, we used C57BL/6 J Apc Min/+ mice, an animal model of human intestinal tumorigenesis, to investigate the gut bacterial diversity and their mechanisms of action in gastrointestinal adenomas, and to evaluate the effects of Yi-Yi-Fu-Zi-Bai-Jiang-San (YYFZBJS) on of colon carcinogenesis in vivo and in vitro. Through humaninto-mice fecal microbiota transplantation (FMT) experiments from YYFZBJS volunteers or control donors, we were able to differentially modulate the tumor microbiome and affect tumor growth as well as tumor immune infiltration.

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Autoimmune thyroid diseases and Th17/Treg lymphocytes

Cited by 60 publications

References 95 publications

Effect of Triptolide on Dextran Sodium Sulfate-Induced Ulcerative Colitis and Gut Microbiota in Mice

Effect of Triptolide on Dextran Sodium Sulfate-Induced Ulcerative Colitis and Gut Microbiota in Mice

Dipeptidyl peptidase 4 inhibitors and their potential immune modulatory functions

YYFZBJS ameliorates colorectal cancer progression in ApcMin/+ mice by remodeling gut microbiota and inhibiting regulatory T-cell generation

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